1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Carotid Arteriopathies, Traumatic in 1 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fasudil is an inhibitor of protein kinases, including myosin light chain kinase and Rho associated kinase, thereby inhibiting myosin phosphorylation, and it has been clinically used to prevent vasospasm following subarachnoid hemorrage." | 5.30 | The kinase inhibitor fasudil (HA-1077) reduces intimal hyperplasia through inhibiting migration and enhancing cell loss of vascular smooth muscle cells. ( Fukui, R; Hoshiga, M; Ii, M; Ishihara, T; Kohbayashi, E; Nakakoji, T; Negoro, N; Nishiguchi, F; Ohsawa, N; Sasaki, Y; Seto, M; Shibata, N, 1999) |
| "Fasudil is an inhibitor of protein kinases, including myosin light chain kinase and Rho associated kinase, thereby inhibiting myosin phosphorylation, and it has been clinically used to prevent vasospasm following subarachnoid hemorrage." | 1.30 | The kinase inhibitor fasudil (HA-1077) reduces intimal hyperplasia through inhibiting migration and enhancing cell loss of vascular smooth muscle cells. ( Fukui, R; Hoshiga, M; Ii, M; Ishihara, T; Kohbayashi, E; Nakakoji, T; Negoro, N; Nishiguchi, F; Ohsawa, N; Sasaki, Y; Seto, M; Shibata, N, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Negoro, N | 1 |
| Hoshiga, M | 1 |
| Seto, M | 1 |
| Kohbayashi, E | 1 |
| Ii, M | 1 |
| Fukui, R | 1 |
| Shibata, N | 1 |
| Nakakoji, T | 1 |
| Nishiguchi, F | 1 |
| Sasaki, Y | 1 |
| Ishihara, T | 1 |
| Ohsawa, N | 1 |
1 other study available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Carotid Arteriopathies, Traumatic
| Article | Year |
|---|---|
The kinase inhibitor fasudil (HA-1077) reduces intimal hyperplasia through inhibiting migration and enhancing cell loss of vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Actins; Animals; Aorta; Carotid A | 1999 |