1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Cardiovascular Diseases in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (60.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shi, J; Wei, L | 1 |
| Chen, YH; Longo, FM; Lu, Q; Massa, SM; Zhou, H | 1 |
| Chayama, K; Fujii, Y; Fujimura, N; Goto, C; Hata, T; Hidaka, T; Higashi, Y; Idei, N; Kihara, Y; Liao, JK; Maruhashi, T; Mikami, S; Noma, K; Soga, J | 1 |
| Chayama, K; Fujii, Y; Fujimura, N; Hata, T; Hidaka, T; Higashi, Y; Idei, N; Kato, H; Kihara, Y; Liao, JK; Maruhashi, T; Mikami, S; Noma, K; Soga, J | 1 |
| Shi, J; Surma, M; Wei, L | 1 |
| Mukai, Y | 1 |
| Shimokawa, H; Tawara, S | 1 |
| Duan, WG; Liao, H; Yan, M; Yuan, ST; Zhang, LY | 1 |
| Hojo, Y; Ikeda, U; Morishita, R; Okada, M; Shimada, K; Takahashi, M; Takizawa, T | 1 |
| Shimokawa, H | 1 |
5 review(s) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Cardiovascular Diseases
| Article | Year |
|---|---|
Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cardiovascular Diseases; Cardiovascular Physiological Phenomena; Drug Design; Humans; Molecular Targeted Therapy; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Signal Transduction | 2013 |
Rho kinase as a therapeutic target in cardiovascular disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Apoptosis; Cardiovascular Diseases; Coronary Artery Disease; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Heart Failure; Humans; Male; Myocytes, Cardiac; Protein Isoforms; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Vasodilation | 2011 |
Progress of the study of rho-kinase and future perspective of the inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cardiovascular Diseases; Cell Proliferation; Drug Design; Enzyme Inhibitors; Forecasting; Humans; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth, Vascular; NF-kappa B; Organogenesis; Protein Kinase C; Protein Serine-Threonine Kinases; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction | 2007 |
[Advances in the study of Rho kinase and its inhibitors].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Antihypertensive Agents; Cardiovascular Diseases; Humans; Pyridines; rho-Associated Kinases; Signal Transduction; Subarachnoid Hemorrhage; Vasodilator Agents | 2007 |
Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cardiovascular Diseases; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Muscle, Smooth, Vascular; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction; Vasodilator Agents | 2002 |
5 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Cardiovascular Diseases
| Article | Year |
|---|---|
Signaling through Rho GTPase pathway as viable drug target.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Aminoquinolines; Anilides; Animals; Benzamides; Cardiovascular Diseases; Humans; Lung Diseases; Neoplasms; Nervous System Diseases; Protein Kinase Inhibitors; Pyridines; Pyrimidines; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction | 2009 |
Measurement of Rho-associated kinase (ROCK) activity in humans: validity of leukocyte p-MBS/t-MBS in comparison with vascular response to fasudil.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Atherosclerosis; Blood Flow Velocity; Cardiovascular Diseases; Dose-Response Relationship, Drug; Female; Humans; Leukocytes; Male; Middle Aged; Myosins; Phosphoric Monoester Hydrolases; rho-Associated Kinases; Vasodilator Agents | 2011 |
Rho-associated kinase activity, endothelial function, and cardiovascular risk factors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Blood Pressure; Blotting, Western; Body Mass Index; Cardiovascular Diseases; Cholesterol, LDL; Endothelium, Vascular; Humans; Hyperemia; Japan; Leukocytes; Male; Middle Aged; Myosin-Light-Chain Phosphatase; Nitroglycerin; Phosphorylation; Prognosis; Protein Kinase Inhibitors; Regression Analysis; rho-Associated Kinases; Risk Assessment; Risk Factors; Ultrasonography, Doppler, Color; Ultrasonography, Doppler, Pulsed; Vasodilation; Vasodilator Agents; Young Adult | 2011 |
[Involvement of Rho-kinase in hypertensive vascular disease--a novel therapeutic target in hypertension].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Vessels; Cardiovascular Diseases; Hypertension; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Protein Serine-Threonine Kinases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases; Signal Transduction; Vascular Resistance; Vasoconstriction; Vasodilator Agents | 2002 |
Interaction between monocytes and vascular smooth muscle cells induces expression of hepatocyte growth factor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Cardiovascular Diseases; Cell Communication; Cells, Cultured; Coculture Techniques; Enzyme Inhibitors; Gene Expression; Genistein; Hepatocyte Growth Factor; Humans; Immunohistochemistry; Inflammation Mediators; Interleukin-1; Interleukin-6; Monocytes; Muscle, Smooth, Vascular; Naphthalenes; Protein Kinase Inhibitors; Protein Kinases; RNA, Messenger; Tumor Necrosis Factor-alpha | 2000 |