1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Cardiac Remodeling, Ventricular in 8 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study was designed to examine the effect of fasudil, a Rho-kinase (ROCK) inhibitor, on myocardial remodeling and underlying mechanisms in pressure overload and myocardial infarction (MI) mice." | 3.78 | Inhibition of Rho-kinase ameliorates myocardial remodeling and fibrosis in pressure overload and myocardial infarction: role of TGF-β1-TAK1. ( Guo, Y; Li, Q; Li, X; Liu, G; Xu, Y, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, ZH | 1 |
| Zhu, D | 1 |
| Xie, S | 1 |
| Deng, Y | 1 |
| Pan, Y | 1 |
| Ren, J | 1 |
| Liu, HG | 1 |
| Mera, C | 1 |
| Godoy, I | 1 |
| Ramírez, R | 1 |
| Moya, J | 1 |
| Ocaranza, MP | 2 |
| Jalil, JE | 2 |
| Ying, Z | 1 |
| Yue, P | 1 |
| Xu, X | 1 |
| Zhong, M | 1 |
| Sun, Q | 1 |
| Mikolaj, M | 1 |
| Wang, A | 1 |
| Brook, RD | 1 |
| Chen, LC | 1 |
| Rajagopalan, S | 1 |
| Xu, EZ | 1 |
| Kantores, C | 1 |
| Ivanovska, J | 1 |
| Engelberts, D | 1 |
| Kavanagh, BP | 1 |
| McNamara, PJ | 1 |
| Jankov, RP | 1 |
| Ho, TJ | 1 |
| Huang, CC | 1 |
| Huang, CY | 1 |
| Lin, WT | 1 |
| Li, Q | 1 |
| Xu, Y | 1 |
| Li, X | 1 |
| Guo, Y | 1 |
| Liu, G | 1 |
| Hattori, T | 1 |
| Shimokawa, H | 1 |
| Higashi, M | 1 |
| Hiroki, J | 1 |
| Mukai, Y | 1 |
| Tsutsui, H | 1 |
| Kaibuchi, K | 1 |
| Takeshita, A | 1 |
| Rivera, P | 1 |
| Lavandero, S | 1 |
8 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Cardiac Remodeling, Ventricular
| Article | Year |
|---|---|
Inhibition of Rho-kinase Attenuates Left Ventricular Remodeling Caused by Chronic Intermittent Hypoxia in Rats via Suppressing Myocardial Inflammation and Apoptosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Hypoxia; Inflammation; Male; Myoc | 2017 |
Mechanisms of favorable effects of Rho kinase inhibition on myocardial remodeling and systolic function after experimental myocardial infarction in the rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Disease Models, Animal; Extracellular Signal | 2016 |
Air pollution and cardiac remodeling: a role for RhoA/Rho-kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Atmosphere Exposure Chambers | 2009 |
Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Age Factors; Aging; Amides; Animals; Apoptosis; Cell | 2010 |
Fasudil, a Rho-kinase inhibitor, protects against excessive endurance exercise training-induced cardiac hypertrophy, apoptosis and fibrosis in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Bi | 2012 |
Inhibition of Rho-kinase ameliorates myocardial remodeling and fibrosis in pressure overload and myocardial infarction: role of TGF-β1-TAK1.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Atrial Natriuretic Factor; Blotting, Western | 2012 |
Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; DNA-Binding Proteins; Drug Administration Sc | 2004 |
Rho kinase activation and gene expression related to vascular remodeling in normotensive rats with high angiotensin I converting enzyme levels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aorta; Blood Pressure; Chemo | 2007 |