1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Cardiac Failure in 12 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study aims to investigate the protective effects of fasudil, a Rho-kinase inhibitor, on pressure overload induced heart failure in rats." | 7.88 | Fasudil alleviates pressure overload-induced heart failure by activating Nrf2-mediated antioxidant responses. ( Guan, P; Liang, Y; Wang, N, 2018) |
| "To study the expression of Rho/Rho kinase of cardiac muscle in heart failure rats caused by pressure overload and the effects of fasudil on heart failure." | 7.73 | [The expression of Rho/Rho kinase of cardiac muscle in heart failure rats caused by pressure overload and the intervention of fasudil]. ( Qu, C; Zeng, DY; Zhang, M, 2005) |
| "Fasudil was well tolerated; one patient discontinued treatment." | 5.42 | Intravenous fasudil improves in-hospital mortality of patients with right heart failure in severe pulmonary hypertension. ( Ai, ZS; Gomberg-Maitland, M; He, J; Jiang, R; Jiang, X; Jing, ZC; Liu, D; Wang, L; Yuan, P; Zhao, QH, 2015) |
| " This study aims to investigate the protective effects of fasudil, a Rho-kinase inhibitor, on pressure overload induced heart failure in rats." | 3.88 | Fasudil alleviates pressure overload-induced heart failure by activating Nrf2-mediated antioxidant responses. ( Guan, P; Liang, Y; Wang, N, 2018) |
| "To study the expression of Rho/Rho kinase of cardiac muscle in heart failure rats caused by pressure overload and the effects of fasudil on heart failure." | 3.73 | [The expression of Rho/Rho kinase of cardiac muscle in heart failure rats caused by pressure overload and the intervention of fasudil]. ( Qu, C; Zeng, DY; Zhang, M, 2005) |
| "Fasudil was well tolerated; one patient discontinued treatment." | 1.42 | Intravenous fasudil improves in-hospital mortality of patients with right heart failure in severe pulmonary hypertension. ( Ai, ZS; Gomberg-Maitland, M; He, J; Jiang, R; Jiang, X; Jing, ZC; Liu, D; Wang, L; Yuan, P; Zhao, QH, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 8 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guan, P | 2 |
| Liang, Y | 1 |
| Wang, N | 2 |
| Yan, X | 1 |
| Jiao, K | 1 |
| Song, X | 1 |
| Jiang, R | 1 |
| Ai, ZS | 1 |
| Jiang, X | 1 |
| Yuan, P | 1 |
| Liu, D | 1 |
| Zhao, QH | 1 |
| He, J | 1 |
| Wang, L | 1 |
| Gomberg-Maitland, M | 1 |
| Jing, ZC | 1 |
| Harris, GS | 1 |
| Lust, RM | 1 |
| Katwa, LC | 1 |
| Wingard, CJ | 1 |
| Zhang, JP | 1 |
| Li, YQ | 1 |
| Chang, YZ | 1 |
| Shi, ZH | 1 |
| Wang, FY | 1 |
| Chu, L | 1 |
| Surma, M | 1 |
| Wei, L | 1 |
| Shi, J | 1 |
| Fukumoto, Y | 1 |
| Haack, KK | 1 |
| Gao, L | 1 |
| Schiller, AM | 1 |
| Curry, PL | 1 |
| Pellegrino, PR | 1 |
| Zucker, IH | 1 |
| Ren, J | 1 |
| Fang, CX | 1 |
| Zhang, M | 1 |
| Qu, C | 1 |
| Zeng, DY | 1 |
| Kishi, T | 1 |
| Hirooka, Y | 1 |
| Masumoto, A | 1 |
| Ito, K | 1 |
| Kimura, Y | 1 |
| Inokuchi, K | 1 |
| Tagawa, T | 1 |
| Shimokawa, H | 1 |
| Takeshita, A | 1 |
| Sunagawa, K | 1 |
| Suzuki, M | 1 |
| Ohte, N | 1 |
| Wang, ZM | 1 |
| Williams, DL | 1 |
| Little, WC | 1 |
| Cheng, CP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Study of Telmisartan (Micardis) For the Prevention of Acute Graft vs. Host Disease Post Allogeneic Hematopoietic Stem Cell Transplantation[NCT02338232] | 32 participants (Actual) | Interventional | 2015-07-07 | Terminated (stopped due to Lack of Accrual) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Cardiac Failure
| Article | Year |
|---|---|
Rho kinase as a therapeutic target in cardiovascular disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Apoptosis; Cardiovascular Diseases; Coronary | 2011 |
Small guanine nucleotide-binding protein Rho and myocardial function.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Heart Failure; Humans; Intracellular | 2005 |
1 trial available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Cardiac Failure
| Article | Year |
|---|---|
Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Case-Control Studies; Dose-Response Relationshi | 2005 |
9 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Cardiac Failure
| Article | Year |
|---|---|
Fasudil alleviates pressure overload-induced heart failure by activating Nrf2-mediated antioxidant responses.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Disease Models, Animal; Heart | 2018 |
Shen'ge powder decreases the cardiomyocyte hypertrophy in chronic heart failure by activating the Rho protein/Rho-associated coiledcoil forming protein kinase signaling pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Cardiomegaly; Cell Survival; Dise | 2019 |
Intravenous fasudil improves in-hospital mortality of patients with right heart failure in severe pulmonary hypertension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Intravenous; Adult; Female; Heart Fai | 2015 |
Urotensin II alters vascular reactivity in animals subjected to volume overload.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Aorta, Thoracic; Arteriovenou | 2010 |
Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses isoproterenol-induced heart failure in rats via JNK and ERK1/2 pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; CASP8 and FADD-Like Apoptosis Regulating Pro | 2011 |
[Fasudil(Rho-kinase inhibitor)].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cardiomyopathy, Dilated; Heart Failure; Mice | 2011 |
Central Rho kinase inhibition restores baroreflex sensitivity and angiotensin II type 1 receptor protein imbalance in conscious rabbits with chronic heart failure.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Baroreflex; Brain Stem; Chronic Disease; Con | 2013 |
[The expression of Rho/Rho kinase of cardiac muscle in heart failure rats caused by pressure overload and the intervention of fasudil].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Female; Heart Failure; Myocardium; Protein K | 2005 |
Altered inotropic response of endothelin-1 in cardiomyocytes from rats with isoproterenol-induced cardiomyopathy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Anti-Arrhythmia Agents; Calcium; | 1998 |