1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Carcinoma, Hepatocellular in 23 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fasudil plays an important role in interfering BTBD7-ROCK2 signaling pathway and suppressing the invasion and metastasis of hepatocellular carcinoma." | 7.80 | [Suppression of hepatocellular carcinoma invasion and metastasis by Rho-kinase inhibitor Fasudil through inhibition of BTBD7-ROCK2 signaling pathway]. ( Hu, K; Tao, Y; Wang, Z, 2014) |
| " We demonstrated that Rho kinase-associated coil-containing protein kinase (ROCK) is expressed in hepatic tissues in hepatocellular carcinoma (HCC) and confirmed its roles in cell survival in HCC cells using the ROCK inhibitor, fasudil." | 7.78 | The Rho kinase inhibitor fasudil is involved in p53-mediated apoptosis in human hepatocellular carcinoma cells. ( Asakura, T; Koizumi, S; Kumai, T; Matsumoto, N; Ohta, Y; Otsubo, T; Takagi, M; Takeba, Y; Takenoshita-Nakaya, S; Watanabe, M, 2012) |
| "Fasudil was loaded by ammonium sulfate-induced transmembrane electrochemical gradient and miR195 was condensed through electrostatic interaction." | 5.43 | Aptamer-functionalized peptide H3CR5C as a novel nanovehicle for codelivery of fasudil and miRNA-195 targeting hepatocellular carcinoma. ( Gao, Y; Gu, S; Li, X; Liu, G; Liu, Y; Wu, X; Zhang, D; Zhang, J; Zhu, G, 2016) |
| "Simvastatin treatment inhibited dose-dependently tumor cell growth and attachment to endothelium." | 5.37 | Simvastatin modulates the adhesion and growth of hepatocellular carcinoma cells via decrease of integrin expression and ROCK. ( Blaheta, R; Henrich, D; Lehnert, M; Marzi, I; Meder, F; Relja, B; Wang, M, 2011) |
| "Fasudil plays an important role in interfering BTBD7-ROCK2 signaling pathway and suppressing the invasion and metastasis of hepatocellular carcinoma." | 3.80 | [Suppression of hepatocellular carcinoma invasion and metastasis by Rho-kinase inhibitor Fasudil through inhibition of BTBD7-ROCK2 signaling pathway]. ( Hu, K; Tao, Y; Wang, Z, 2014) |
| " We demonstrated that Rho kinase-associated coil-containing protein kinase (ROCK) is expressed in hepatic tissues in hepatocellular carcinoma (HCC) and confirmed its roles in cell survival in HCC cells using the ROCK inhibitor, fasudil." | 3.78 | The Rho kinase inhibitor fasudil is involved in p53-mediated apoptosis in human hepatocellular carcinoma cells. ( Asakura, T; Koizumi, S; Kumai, T; Matsumoto, N; Ohta, Y; Otsubo, T; Takagi, M; Takeba, Y; Takenoshita-Nakaya, S; Watanabe, M, 2012) |
| "Fasudil was loaded by ammonium sulfate-induced transmembrane electrochemical gradient and miR195 was condensed through electrostatic interaction." | 1.43 | Aptamer-functionalized peptide H3CR5C as a novel nanovehicle for codelivery of fasudil and miRNA-195 targeting hepatocellular carcinoma. ( Gao, Y; Gu, S; Li, X; Liu, G; Liu, Y; Wu, X; Zhang, D; Zhang, J; Zhu, G, 2016) |
| "Simvastatin treatment inhibited dose-dependently tumor cell growth and attachment to endothelium." | 1.37 | Simvastatin modulates the adhesion and growth of hepatocellular carcinoma cells via decrease of integrin expression and ROCK. ( Blaheta, R; Henrich, D; Lehnert, M; Marzi, I; Meder, F; Relja, B; Wang, M, 2011) |
| "The human hepatoma cell line HuH-7, which constitutively expresses c-myc, was stably transfected with sense and antisense c-myc expression vectors under the control of the zinc-inducible metallothionein promoter." | 1.29 | Induction of hepatoma cell apoptosis by c-myc requires zinc and occurs in the absence of DNA fragmentation. ( Czaja, MJ; Nguyen, Q; Novikoff, PM; Xu, J; Xu, Y, 1996) |
| "A human hepatoma-derived cell line, Mahlavu, was analyzed for the production of HB-EGF mRNA and active HB-EGF protein." | 1.29 | Regulation of heparin-binding EGF-like growth factor expression by phorbol ester in a human hepatoma-derived cell line. ( Higashiyama, S; Ito, N; Kawata, S; Kiso, S; Matsuzawa, Y; Nakagawa, T; Tamura, S; Taniguchi, N; Tsushima, H, 1996) |
| "Using the human hepatoma cell line Hep G2, we have studied a possible role of protein kinase C (PKC) activity for regulation of erythropoietin (EPO) production." | 1.28 | Phorbol ester inhibits erythropoietin production in human hepatoma cells (Hep G2). ( Corvol, P; Eckardt, KU; Fabbro, D; Kurtz, A; Pugh, C; Ratcliffe, P, 1992) |
| "In a hepatoma cell line (HepG2) the polypeptide very potently increased low density lipoprotein (LDL) uptake with an EC50 of 0." | 1.28 | Oncostatin M up-regulates low density lipoprotein receptors in HepG2 cells by a novel mechanism. ( Grove, RI; Kiener, PA; Mazzucco, CE; Radka, SF; Shoyab, M, 1991) |
| "Membranes from the human hepatoma cell line HepG2 mediate the phosphorylation on tyrosine of the asialoglycoprotein receptor." | 1.28 | Staurosporine inhibits a tyrosine protein kinase in human hepatoma cell membranes. ( Fallon, RJ, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (52.17) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 5 (21.74) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, Y | 1 |
| Zhang, Y | 1 |
| Vazirinejad Mehdiabad, M | 1 |
| Zhou, K | 1 |
| Chen, Y | 2 |
| Li, L | 2 |
| Guo, J | 2 |
| Xu, C | 2 |
| Wu, H | 1 |
| Li, B | 1 |
| Li, C | 1 |
| You, J | 1 |
| Hu, X | 1 |
| Kuang, D | 1 |
| Qi, S | 1 |
| Liu, P | 1 |
| Hu, K | 1 |
| Wang, Z | 1 |
| Tao, Y | 1 |
| Liu, Y | 1 |
| Wu, X | 1 |
| Gao, Y | 1 |
| Zhang, J | 1 |
| Zhang, D | 1 |
| Gu, S | 1 |
| Zhu, G | 1 |
| Liu, G | 1 |
| Li, X | 1 |
| Grise, F | 1 |
| Bidaud, A | 1 |
| Moreau, V | 1 |
| Relja, B | 1 |
| Meder, F | 1 |
| Wang, M | 1 |
| Blaheta, R | 1 |
| Henrich, D | 1 |
| Marzi, I | 1 |
| Lehnert, M | 1 |
| Takeba, Y | 1 |
| Matsumoto, N | 1 |
| Watanabe, M | 1 |
| Takenoshita-Nakaya, S | 1 |
| Ohta, Y | 1 |
| Kumai, T | 1 |
| Takagi, M | 1 |
| Koizumi, S | 1 |
| Asakura, T | 1 |
| Otsubo, T | 1 |
| Wu, BW | 1 |
| Wu, Y | 1 |
| Wang, JL | 1 |
| Lin, JS | 1 |
| Yuan, SY | 1 |
| Li, A | 1 |
| Cui, WR | 1 |
| Ren, Y | 1 |
| Smith, A | 1 |
| Thompson, D | 1 |
| Whicher, JT | 1 |
| Evans, SW | 1 |
| Hirano, F | 1 |
| Tanaka, H | 1 |
| Makino, Y | 1 |
| Okamoto, K | 1 |
| Inaba, M | 1 |
| Miura, T | 1 |
| Makino, I | 1 |
| Kasckow, JW | 1 |
| Mulcahey, JJ | 1 |
| Han, JH | 1 |
| Owens, MJ | 1 |
| Stipetic, MD | 1 |
| Breitman, D | 1 |
| Nemeroff, CB | 1 |
| Nakajima, K | 2 |
| Kusafuka, T | 1 |
| Takeda, T | 1 |
| Fujitani, Y | 1 |
| Nakae, K | 1 |
| Hirano, T | 2 |
| Xu, J | 1 |
| Xu, Y | 1 |
| Nguyen, Q | 1 |
| Novikoff, PM | 1 |
| Czaja, MJ | 1 |
| Ito, N | 2 |
| Higashiyama, S | 1 |
| Kawata, S | 2 |
| Tamura, S | 2 |
| Kiso, S | 1 |
| Tsushima, H | 1 |
| Nakagawa, T | 1 |
| Matsuzawa, Y | 1 |
| Taniguchi, N | 1 |
| Tacchini, L | 1 |
| Dansi, P | 1 |
| Matteucci, E | 1 |
| Desiderio, MA | 1 |
| Kim, SA | 1 |
| Um, SJ | 1 |
| Kang, JH | 1 |
| Hong, KJ | 1 |
| Abe, K | 1 |
| Hirai, M | 1 |
| Mizuno, K | 1 |
| Higashi, N | 1 |
| Sekimoto, T | 1 |
| Miki, T | 1 |
| Kurtz, A | 1 |
| Eckardt, KU | 1 |
| Pugh, C | 1 |
| Corvol, P | 1 |
| Fabbro, D | 1 |
| Ratcliffe, P | 1 |
| Towata, T | 1 |
| Hayashi, N | 1 |
| Katayama, K | 1 |
| Takehara, T | 1 |
| Sasaki, Y | 1 |
| Kasahara, A | 1 |
| Fusamoto, H | 1 |
| Kamada, T | 1 |
| Grove, RI | 1 |
| Mazzucco, CE | 1 |
| Radka, SF | 1 |
| Shoyab, M | 1 |
| Kiener, PA | 1 |
| Fallon, RJ | 1 |
| Takaishi, K | 1 |
| Shirai, Y | 1 |
| Tarui, S | 1 |
1 review available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Rho GTPases in hepatocellular carcinoma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Carcinoma, Hepatocellular; Disease P | 2009 |
22 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Enhanced anti-tumor effect of liposomal Fasudil on hepatocellular carcinoma in vitro and in vivo.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antineoplastic Agents; Apoptosis; Apoptosis | 2019 |
Targeting ROCK1/2 blocks cell division and induces mitotic catastrophe in hepatocellular carcinoma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell D | 2021 |
[Suppression of hepatocellular carcinoma invasion and metastasis by Rho-kinase inhibitor Fasudil through inhibition of BTBD7-ROCK2 signaling pathway].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adaptor Proteins, Signal Transducing; Carcinoma, Hepa | 2014 |
Aptamer-functionalized peptide H3CR5C as a novel nanovehicle for codelivery of fasudil and miRNA-195 targeting hepatocellular carcinoma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Ammonium Sulfate; Angiogenesis Inhibitors; Animals; A | 2016 |
Simvastatin modulates the adhesion and growth of hepatocellular carcinoma cells via decrease of integrin expression and ROCK.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antineoplastic Combined Chemotherapy Protocols; Carci | 2011 |
The Rho kinase inhibitor fasudil is involved in p53-mediated apoptosis in human hepatocellular carcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumo | 2012 |
Study on the mechanism of epidermal growth factor-induced proliferation of hepatoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoma, Hepatocellular; Cell Division; Enzyme Inhi | 2003 |
Mechanism of metallothionein gene regulation by heme-hemopexin. Roles of protein kinase C, reactive oxygen species, and cis-acting elements.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Base Sequence; Carcinoma, Hepatocellular; Ce | 1995 |
Interleukin 6 signal transduction in a human hepatoma cell line (Hep G2).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute-Phase Proteins; Alkaloids; Carcinoma, Hepatocel | 1993 |
Regulation of the major histocompatibility complex class I mRNA expression by bile acids in cultured human hepatoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bile Acids and Salts; Carcinoma, Hepatocellular; Cell | 1995 |
Interleukin-1 alpha induces corticotropin-releasing factor secretion and synthesis from NPLC-KC cells through various second messenger pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoma, Hepatocellular; Corticotropin-Releasing Ho | 1994 |
Identification of a novel interleukin-6 response element containing an Ets-binding site and a CRE-like site in the junB promoter.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Base Sequence; beta-Galactosidase; Binding Sites; Car | 1993 |
Induction of hepatoma cell apoptosis by c-myc requires zinc and occurs in the absence of DNA fragmentation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Cadmium Poisoning; Carcinoma, Hep | 1996 |
Regulation of heparin-binding EGF-like growth factor expression by phorbol ester in a human hepatoma-derived cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoma, Hepatocellular; Cycloheximide; Epidermal G | 1996 |
Hepatocyte growth factor signal coupling to various transcription factors depends on triggering of Met receptor and protein kinase transducers in human hepatoma cells HepG2.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Basic Helix-Loop-Helix Leucine Zipper Transcription F | 2000 |
Expression of thrombospondin-1 in human hepatocarcinoma cell lines and its regulation by transcription factor Jun/AP-1.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Binding Sites; Blotting, Northern; Blotting, Western; | 2001 |
The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alanine; Amino Acid Sequence; Amino Acid S | 2001 |
Phorbol ester inhibits erythropoietin production in human hepatoma cells (Hep G2).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Carcinoma, Hepatocellular; Erythropoietin; | 1992 |
Signal transduction pathways in the induction of HLA class I antigen expression on Huh 6 cells by interferon-gamma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcimycin; Calmodulin; Carcinoma, Hepatocellular; Ce | 1991 |
Oncostatin M up-regulates low density lipoprotein receptors in HepG2 cells by a novel mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoma, Hepatocellular; Cross-Linking Reagents; Cy | 1991 |
Staurosporine inhibits a tyrosine protein kinase in human hepatoma cell membranes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Asialoglycoprotein Receptor; Carcinoma, He | 1990 |
Effects of phorbol ester on cell growth inhibition by transforming growth factor beta 1 in human hepatoma cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Carcinoma, Hepatocellular; Cell Division; | 1990 |