1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Carcinoma, Anaplastic in 9 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the present study we have analyzed the effect of a synthetic protein kinase C (PKC) activator 3-(N-acetylamino)-5-(N-decyl-N-methylamino)-benzyl alcohol (ADMB) and the natural PKC-activating tumor-promoting agents 12-O-tetradecanoylphorbol 13-acetate (TPA) and mezerein on the antigenic phenotype of T47D human breast carcinoma cells." | 3.68 | Modulation of the antigenic phenotype of human breast carcinoma cells by modifiers of protein kinase C activity and recombinant human interferons. ( Estabrook, A; Fisher, PB; Gutierrez, MC; Jiang, H; Leon, JA; Waxman, S, 1992) |
| "alpha 2-adrenergic receptor-mediated signal transduction in rat adrenocortical carcinoma cells occurs through the opposing regulation of two second messengers, cyclic GMP and cyclic AMP, in which guanylate cyclase is coupled positively and adenylate cyclase negatively to the receptor signal." | 3.67 | Inhibition of alpha 2-adrenergic receptor-mediated cyclic GMP formation by a phorbol ester, a protein kinase C activator. ( Jaiswal, RK; Sharma, RK, 1988) |
| "The poor prognosis of advanced ovarian cancer comes from increased invasiveness of human ovarian cancer cells." | 1.35 | Fasudil inhibits lysophosphatidic acid-induced invasiveness of human ovarian cancer cells. ( Hashimoto, K; Kawase, C; Kimura, T; Mabuchi, S; Morishige, K; Ogata, S; Ooyagi, C; Sakata, M; Sawada, K, 2009) |
| "Human parathyroid adenoma cells and bovine cells cultured for 1 day or exposed to a low concentration of a monoclonal antiparathyroid antibody exhibited right-shifted dependencies of PTH release and Ca2+i on extracellular Ca2+ and reduced Ca2+i transients." | 1.27 | Modulation of the Ca2+-sensing function of parathyroid cells in vitro and in hyperparathyroidism. ( Akerström, G; Gylfe, E; Johansson, H; Juhlin, C; Klareskoq, L; Larsson, R; Nygren, P; Rastad, J, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guerra, FS | 1 |
| Oliveira, RG | 1 |
| Fraga, CAM | 1 |
| Mermelstein, CDS | 1 |
| Fernandes, PD | 1 |
| Ogata, S | 1 |
| Morishige, K | 1 |
| Sawada, K | 1 |
| Hashimoto, K | 1 |
| Mabuchi, S | 1 |
| Kawase, C | 1 |
| Ooyagi, C | 1 |
| Sakata, M | 1 |
| Kimura, T | 1 |
| Yang, X | 1 |
| Zhang, Y | 1 |
| Wang, S | 1 |
| Shi, W | 1 |
| Kaji, M | 1 |
| Ishikura, H | 1 |
| Kishimoto, T | 1 |
| Omi, M | 1 |
| Ishizu, A | 1 |
| Kimura, C | 1 |
| Takahashi, T | 1 |
| Kato, H | 1 |
| Yoshiki, T | 1 |
| Fournès, B | 1 |
| Sadekova, S | 1 |
| Turbide, C | 1 |
| Létourneau, S | 1 |
| Beauchemin, N | 1 |
| Takahashi, K | 1 |
| Kwaan, HC | 1 |
| Ikeo, K | 1 |
| Koh, E | 1 |
| Leon, JA | 1 |
| Gutierrez, MC | 1 |
| Jiang, H | 1 |
| Estabrook, A | 1 |
| Waxman, S | 1 |
| Fisher, PB | 1 |
| Jaiswal, RK | 1 |
| Sharma, RK | 1 |
| Nygren, P | 1 |
| Gylfe, E | 1 |
| Larsson, R | 1 |
| Johansson, H | 1 |
| Juhlin, C | 1 |
| Klareskoq, L | 1 |
| Akerström, G | 1 |
| Rastad, J | 1 |
9 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Carcinoma, Anaplastic
| Article | Year |
|---|---|
ROCK inhibition with Fasudil induces beta-catenin nuclear translocation and inhibits cell migration of MDA-MB 231 human breast cancer cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antineoplastic Agents; beta Catenin; Carcinoma; Cell | 2017 |
Fasudil inhibits lysophosphatidic acid-induced invasiveness of human ovarian cancer cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antineoplastic Agents; Carcinoma; Cell Movem | 2009 |
Effect of fasudil on growth, adhesion, invasion, and migration of 95D lung carcinoma cells in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antineoplastic Agents; Carcinoma; Cell Adhesion; Cell | 2010 |
E-selectin expression induced by pancreas-carcinoma-derived interleukin-1 alpha results in enhanced adhesion of pancreas-carcinoma cells to endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; CA-19-9 Antigen; Carcinoma; Cell Adhesion; Cell Adhes | 1995 |
The CEACAM1-L Ser503 residue is crucial for inhibition of colon cancer cell tumorigenicity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Antigens, CD; Antigens, | 2001 |
Phosphorylation of a surface receptor bound urokinase-type plasminogen activator in a human metastatic carcinomatous cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Blotting, Western; Carcinoma; | 1992 |
Modulation of the antigenic phenotype of human breast carcinoma cells by modifiers of protein kinase C activity and recombinant human interferons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Benzyl Alcohols; Breast Neoplasms; Carcinoma; Cell Ad | 1992 |
Inhibition of alpha 2-adrenergic receptor-mediated cyclic GMP formation by a phorbol ester, a protein kinase C activator.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Cortex Neoplasms; Animals; Carcinoma; Clonidi | 1988 |
Modulation of the Ca2+-sensing function of parathyroid cells in vitro and in hyperparathyroidism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenoma; Animals; Antibodies, Monoclonal; Calcium; Ca | 1988 |