1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Cancer of Lung in 16 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "After treatment to NCI-H446 small cell lung cancer cells with Fasudil, a Rho-kinase inhibitor, cell biological behaviors were observed." | 1.38 | The Rho-kinase inhibitor inhibits proliferation and metastasis of small cell lung cancer. ( Di, J; Liu, J; Lu, J; Shi, W; Yang, X; Zhang, S; Zhang, Y, 2012) |
| "Fasudil is a kind of Rho kinase inhibitor." | 1.37 | Rho kinase inhibitor fasudil suppresses migration and invasion though down-regulating the expression of VEGF in lung cancer cell line A549. ( Li, Z; Nong, L; Ren, J; Wu, G; Zhang, R; Zhang, Z; Zhu, F, 2011) |
| "Treatment with fasudil inhibited the growth of 95-D cells in a dose-dependent manner, and the IC50 of fasudil was approximately 0." | 1.36 | The Rho kinase inhibitor fasudil inhibits the migratory behaviour of 95-D lung carcinoma cells. ( Liu, Y; Tian, D; Yang, X; Zong, Z, 2010) |
| "Inhibition of metastasis was time dependent, with 90% of maximum inhibition occurring by 8 h of incubation." | 1.28 | Inhibition of experimental metastasis and cell adhesion of B16F1 melanoma cells by inhibitors of protein kinase C. ( Bitonti, AJ; Dumont, JA; Jones, WD, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (37.50) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 8 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Park, JM | 1 |
| Han, YM | 1 |
| Jeong, M | 1 |
| Chung, MH | 1 |
| Kwon, CI | 1 |
| Ko, KH | 1 |
| Hahm, KB | 1 |
| Guerra, FS | 1 |
| Oliveira, RG | 1 |
| Fraga, CAM | 1 |
| Mermelstein, CDS | 1 |
| Fernandes, PD | 1 |
| Xia, Y | 1 |
| Cai, XY | 1 |
| Fan, JQ | 1 |
| Zhang, LL | 1 |
| Ren, JH | 2 |
| Li, ZY | 2 |
| Zhang, RG | 1 |
| Zhu, F | 2 |
| Wu, G | 3 |
| Yang, X | 3 |
| Liu, Y | 1 |
| Zong, Z | 1 |
| Tian, D | 1 |
| Zhang, Z | 2 |
| Li, Z | 1 |
| Zhang, R | 1 |
| Ren, J | 1 |
| Nong, L | 2 |
| Zhang, Y | 2 |
| Wang, S | 1 |
| Shi, W | 2 |
| Di, J | 1 |
| Zhang, S | 1 |
| Lu, J | 1 |
| Liu, J | 1 |
| Tsubaki, M | 1 |
| Matsuoka, H | 1 |
| Yamamoto, C | 1 |
| Kato, C | 1 |
| Ogaki, M | 1 |
| Satou, T | 1 |
| Itoh, T | 1 |
| Kusunoki, T | 1 |
| Tanimori, Y | 1 |
| Nishida, S | 1 |
| Hakomori, S | 1 |
| Koong, AC | 1 |
| Giaccia, AJ | 1 |
| Hahn, GM | 1 |
| Saad, AH | 1 |
| Williams, CL | 2 |
| Phelps, SH | 2 |
| Porter, RA | 2 |
| Jakowlew, SB | 1 |
| Mariano, JM | 1 |
| You, L | 1 |
| Leyton, J | 1 |
| Garcia-Marin, LJ | 1 |
| Tapia, JA | 1 |
| Jensen, RT | 1 |
| Moody, TW | 1 |
| Dumont, JA | 1 |
| Jones, WD | 1 |
| Bitonti, AJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Study of Telmisartan (Micardis) For the Prevention of Acute Graft vs. Host Disease Post Allogeneic Hematopoietic Stem Cell Transplantation[NCT02338232] | 32 participants (Actual) | Interventional | 2015-07-07 | Terminated (stopped due to Lack of Accrual) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
16 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Cancer of Lung
| Article | Year |
|---|---|
Synthetic 8-hydroxydeoxyguanosine inhibited metastasis of pancreatic cancer through concerted inhibitions of ERM and Rho-GTPase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Animals; | 2017 |
ROCK inhibition with Fasudil induces beta-catenin nuclear translocation and inhibits cell migration of MDA-MB 231 human breast cancer cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antineoplastic Agents; beta Catenin; Carcinoma; Cell | 2017 |
The role of sema4D in vasculogenic mimicry formation in non-small cell lung cancer and the underlying mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; A549 Cells; Animals; Antigens, CD; Carcinoma, Non-Sma | 2019 |
The Rho kinase inhibitor fasudil inhibits the migratory behaviour of 95-D lung carcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ATP-Binding Cassette Transporters; Cell Line, Tumor; | 2010 |
Rho kinase inhibitor fasudil suppresses migration and invasion though down-regulating the expression of VEGF in lung cancer cell line A549.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antineoplastic Agents; Blotting, Western; Cell Line, | 2011 |
Effect of fasudil on growth, adhesion, invasion, and migration of 95D lung carcinoma cells in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antineoplastic Agents; Carcinoma; Cell Adhesion; Cell | 2010 |
Fasudil inhibits lung carcinoma-conditioned endothelial cell viability and migration.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenocarcinoma; Adenocarcinoma of Lung; Angiogenesis | 2012 |
The Rho-kinase inhibitor inhibits proliferation and metastasis of small cell lung cancer.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Caspase 3; Cell Adhesion; Cell Line, Tumor | 2012 |
The protein kinase C inhibitor, H7, inhibits tumor cell invasion and metastasis in mouse melanoma via suppression of ERK1/2.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Base Sequence; Cell Line, Tumor; DNA Primers | 2007 |
Novel endothelial cell activation factor(s) released from activated platelets which induce E-selectin expression and tumor cell adhesion to endothelial cells: a preliminary note.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Biological Factors; Cell Adhesion | 1994 |
Activation of potassium channels by hypoxia and reoxygenation in the human lung adenocarcinoma cell line A549.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcysteine; Adenocarcinoma; Alkaloids; Free Radic | 1993 |
Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cel
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Calcium-Calmodulin-Dependent Protein Kinase | 1996 |
Inhibition of voltage-gated Ca2+ channel activity in small cell lung carcinoma by the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperaz ine) .
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Calcium Channel Blockers; Calcium Channels; | 1995 |
Effects of transforming growth factor-beta 1 and phorbol ester on PAI-1 and PA genes in human lung cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Northern; Bronchi; Carcinoma, Non-Small-Cel | 1997 |
Bombesin and gastrin releasing peptide increase tyrosine phosphorylation of focal adhesion kinase and paxillin in non-small cell lung cancer cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bombesin; Carcinoma, Non-Small-Cell Lung; Cell Divisi | 2001 |
Inhibition of experimental metastasis and cell adhesion of B16F1 melanoma cells by inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Adhesion; Isoquinolines; Lun | 1992 |