1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Breast Neoplasms in 17 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was conducted to develop novel fasudil derivatives after incorporation of substituted thiazoles as potent anti-breast cancer (BC) agents." | 8.02 | Design and development of novel fasudil derivatives as potent antibreast cancer agent that improves intestinal flora and intestinal barrier function in rats. ( Fu, A; Huang, R; Liang, J; Tang, M; Wang, L; Zhou, J, 2021) |
| "This study was conducted to develop novel fasudil derivatives after incorporation of substituted thiazoles as potent anti-breast cancer (BC) agents." | 4.02 | Design and development of novel fasudil derivatives as potent antibreast cancer agent that improves intestinal flora and intestinal barrier function in rats. ( Fu, A; Huang, R; Liang, J; Tang, M; Wang, L; Zhou, J, 2021) |
| "In the present study we have analyzed the effect of a synthetic protein kinase C (PKC) activator 3-(N-acetylamino)-5-(N-decyl-N-methylamino)-benzyl alcohol (ADMB) and the natural PKC-activating tumor-promoting agents 12-O-tetradecanoylphorbol 13-acetate (TPA) and mezerein on the antigenic phenotype of T47D human breast carcinoma cells." | 3.68 | Modulation of the antigenic phenotype of human breast carcinoma cells by modifiers of protein kinase C activity and recombinant human interferons. ( Estabrook, A; Fisher, PB; Gutierrez, MC; Jiang, H; Leon, JA; Waxman, S, 1992) |
| "Injected human leukemic and breast cancer cells exhibited cell-type specific patterns of intravascular distribution with leukemic cells moving faster than breast cancer cells." | 1.56 | Long-term in vivo imaging reveals tumor-specific dissemination and captures host tumor interaction in zebrafish xenografts. ( Asokan, N; Bernas, SN; Bornhäuser, M; Brand, M; Daetwyler, S; Huisken, J; Kempermann, G; Lambert, K; Schmied, C; Vogler, S; Wermke, M; Wobus, M, 2020) |
| "Fasudil has been approved for the treatment of cerebral vasospasm and associated cerebral ischemic symptoms." | 1.33 | The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models. ( Alicke, B; Biroc, SL; Dinter, H; Kamata, Y; Li, WW; Ohashi, Y; Okada, T; Pagila, R; Xuan, JA; Ying, H, 2006) |
| "Here we show that breast cancer cells exhibiting a highly resistant phenotype undergo apoptosis when exposed to concurrent heat shock and H7, a potent serine/threonine kinase inhibitor." | 1.32 | Concurrent exposure to heat shock and H7 synergizes to trigger breast cancer cell apoptosis while sparing normal cells. ( Goodman, M; Hardy, L; Liu, L; Spector, NL; Voellmy, R; Xia, W; Zhao, S, 2003) |
| "The release of these two enzymes in breast cancer was higher than that in adjacent normal breast tissue and fibroadenoma." | 1.32 | Augmented release of matrix metalloproteinase-9 by PKC activation in organotypic cultures of human breast cancer and adjacent normal breast tissue and fibroadenoma. ( Hsieh, HY; Hsieh, YS; Huang, CY; Kuo, SJ; Liu, JY; Tsai, JH; Wu, TT; Yu, SY, 2004) |
| "Using breast cancer cell lines derived from transgenic mice that overexpress specific oncogene/growth factors in the mammary gland, we show that heregulin but not her2/neu, c-Myc or v-Ha-ras plays a major role in constitutive NF-kappaB activation." | 1.31 | Identification of signal transduction pathways involved in constitutive NF-kappaB activation in breast cancer cells. ( Bhat-Nakshatri, P; Nakshatri, H; Sweeney, CJ, 2002) |
| "Fresh frozen breast carcinoma tissues were examined for the presence of GPIb alpha by immunohistochemistry." | 1.30 | A GPIb alpha-related protein is expressed by fresh human breast carcinoma tissue and is regulated by a PKC-sensitive mechanism. ( DeLeon-Fernandez, M; Dutcher, JP; Etkind, P; Oleksowicz, L, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (52.94) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Liang, J | 1 |
| Tang, M | 1 |
| Wang, L | 1 |
| Huang, R | 1 |
| Fu, A | 1 |
| Zhou, J | 1 |
| Asokan, N | 1 |
| Daetwyler, S | 1 |
| Bernas, SN | 1 |
| Schmied, C | 1 |
| Vogler, S | 1 |
| Lambert, K | 1 |
| Wobus, M | 1 |
| Wermke, M | 1 |
| Kempermann, G | 1 |
| Huisken, J | 1 |
| Brand, M | 1 |
| Bornhäuser, M | 1 |
| Gogebakan, B | 1 |
| Bayraktar, R | 1 |
| Suner, A | 1 |
| Balakan, O | 1 |
| Ulasli, M | 1 |
| Izmirli, M | 1 |
| Oztuzcu, S | 1 |
| Camci, C | 1 |
| Ma, L | 1 |
| Liu, YP | 1 |
| Zhang, XH | 1 |
| Xing, LX | 1 |
| Wang, JL | 1 |
| Geng, CZ | 1 |
| Xia, W | 1 |
| Hardy, L | 1 |
| Liu, L | 1 |
| Zhao, S | 1 |
| Goodman, M | 1 |
| Voellmy, R | 1 |
| Spector, NL | 1 |
| Wu, TT | 1 |
| Tsai, JH | 2 |
| Kuo, SJ | 1 |
| Yu, SY | 1 |
| Huang, CY | 1 |
| Hsieh, HY | 1 |
| Hsieh, YS | 1 |
| Liu, JY | 1 |
| Ying, H | 1 |
| Biroc, SL | 1 |
| Li, WW | 1 |
| Alicke, B | 1 |
| Xuan, JA | 1 |
| Pagila, R | 1 |
| Ohashi, Y | 1 |
| Okada, T | 1 |
| Kamata, Y | 1 |
| Dinter, H | 1 |
| Lee, YJ | 2 |
| Galoforo, SS | 1 |
| Berns, CM | 2 |
| Erdos, G | 2 |
| Gupta, AK | 1 |
| Ways, DK | 1 |
| Corry, PM | 2 |
| Martin, MB | 1 |
| Garcia-Morales, P | 1 |
| Stoica, A | 1 |
| Solomon, HB | 1 |
| Pierce, M | 1 |
| Katz, D | 1 |
| Zhang, S | 1 |
| Danielsen, M | 1 |
| Saceda, M | 2 |
| Martínez-Lacaci, I | 1 |
| Plowman, GD | 1 |
| Johnson, GR | 1 |
| Normanno, N | 1 |
| Salomon, DS | 1 |
| Dickson, RB | 1 |
| Jeoung, DI | 1 |
| Tang, B | 1 |
| Sonenberg, M | 1 |
| Pusztai, L | 1 |
| Lewis, CE | 1 |
| McGee, JO | 1 |
| Oleksowicz, L | 1 |
| Dutcher, JP | 1 |
| DeLeon-Fernandez, M | 1 |
| Etkind, P | 1 |
| Bhat-Nakshatri, P | 1 |
| Sweeney, CJ | 1 |
| Nakshatri, H | 1 |
| Leon, JA | 1 |
| Gutierrez, MC | 1 |
| Jiang, H | 1 |
| Estabrook, A | 1 |
| Waxman, S | 1 |
| Fisher, PB | 1 |
| Miñana, MD | 1 |
| Felipo, V | 1 |
| Cortés, F | 1 |
| Grisolía, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Study of Telmisartan (Micardis) For the Prevention of Acute Graft vs. Host Disease Post Allogeneic Hematopoietic Stem Cell Transplantation[NCT02338232] | 32 participants (Actual) | Interventional | 2015-07-07 | Terminated (stopped due to Lack of Accrual) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
17 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Breast Neoplasms
| Article | Year |
|---|---|
Design and development of novel fasudil derivatives as potent antibreast cancer agent that improves intestinal flora and intestinal barrier function in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antineoplastic Agents; Breast Neoplasms; Col | 2021 |
Long-term in vivo imaging reveals tumor-specific dissemination and captures host tumor interaction in zebrafish xenografts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Tra | 2020 |
Do fasudil and Y-27632 affect the level of transient receptor potential (TRP) gene expressions in breast cancer cell lines?
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Breast Neoplasms; Cell Line, Tumor; Female; H | 2014 |
Effect of RhoA signaling transduction on expression of Ezrin in breast cancer cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Western; Breast Neoplasms; Cell Line, Tumor | 2009 |
Concurrent exposure to heat shock and H7 synergizes to trigger breast cancer cell apoptosis while sparing normal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antineoplastic Combined Chemotherapy Protocols; Apopt | 2003 |
Augmented release of matrix metalloproteinase-9 by PKC activation in organotypic cultures of human breast cancer and adjacent normal breast tissue and fibroadenoma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Breast; Breast Neoplasms; Concanavalin A; Cycloheximi | 2004 |
The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Breast Neoplasms; Cell Adhesion; Cell Growth | 2006 |
Effect of ionizing radiation on AP-1 binding activity and basic fibroblast growth factor gene expression in drug-sensitive human breast carcinoma MCF-7 and multidrug-resistant MCF-7/ADR cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Base Sequence; Breast Neoplasms; Cell Survival; Drug | 1995 |
Effects of 12-O-tetradecanoylphorbol-13-acetate on estrogen receptor activity in MCF-7 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Base Sequence; Breast Neoplasms; Dose-Response Relati | 1995 |
Estrogen and phorbol esters regulate amphiregulin expression by two separate mechanisms in human breast cancer cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amphiregulin; Antineoplastic Agents; Blotting, Wester | 1995 |
Induction of tumor suppressor p21 protein by kinase inhibitors in MCF-7 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Breast Neoplasms; Bucladesine; Cell Cycle; | 1995 |
Effect of isoquinolinesulfonamides on heat shock gene expression during heating at 41 degrees C in human carcinoma cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Northern; Breast Neoplasms; Cyclic AMP-Depe | 1994 |
Growth arrest of the breast cancer cell line, T47D, by TNF alpha; cell cycle specificity and signal transduction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltra | 1993 |
A GPIb alpha-related protein is expressed by fresh human breast carcinoma tissue and is regulated by a PKC-sensitive mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Breast; Breast Neoplasms; Car | 1997 |
Identification of signal transduction pathways involved in constitutive NF-kappaB activation in breast cancer cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Breast Neoplasms; Cell Su | 2002 |
Modulation of the antigenic phenotype of human breast carcinoma cells by modifiers of protein kinase C activity and recombinant human interferons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Benzyl Alcohols; Breast Neoplasms; Carcinoma; Cell Ad | 1992 |
Inhibition of protein kinase C arrests proliferation of human tumors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bone Neoplasms; Brain Neoplasms; Breast Neoplasms; Ce | 1991 |