Page last updated: 2024-10-28

1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Brain Ischemia

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Brain Ischemia in 42 studies

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"Fasudil is believed to be at least equally effective as nimodipine for the prevention of cerebral vasospasm and subsequent ischemic injury in patients undergoing surgery for subarachnoid hemorrhage (SAH)."9.15Efficacy and safety of fasudil in patients with subarachnoid hemorrhage: final results of a randomized trial of fasudil versus nimodipine. ( Guo, J; Mao, Y; Ren, Z; Wang, R; Wang, S; Xu, B; Zhang, X; Zhang, Y; Zhao, J; Zhao, K; Zhou, D; Zhou, L, 2011)
" This randomized open trial with nimodipine as the control included 72 patients who underwent subarachnoid hemorrhage surgery for ruptured cerebral aneurysm of Hunt and Hess grades I to IV."9.12Effect of fasudil hydrochloride, a protein kinase inhibitor, on cerebral vasospasm and delayed cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhage. ( Guo, J; Ren, Z; Wang, R; Wang, S; Xu, B; Zhao, J; Zhou, D; Zhou, L, 2006)
"Treatment with fasudil within 48 h of acute ischemic stroke onset significantly improved the patient's clinical outcome."9.11Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial. ( Hirai, S; Ohtomo, E; Satoh, S; Seto, M; Shibuya, M, 2005)
" To date, the only Rho-kinase inhibitor employed clinically in humans is fasudil, which has been used for the prevention of cerebral vasospasm and subsequent ischemic injury after surgery for subarachnoid hemorrhage (SAH)."8.90Pleiotropic effects of the rho-kinase inhibitor fasudil after subarachnoid hemorrhage: a review of preclinical and clinical studies. ( Asano, T; Ikegaki, I; Kawasaki, K; Satoh, S; Shibuya, M, 2014)
"Early CIMT promotes motor recovery after acute ischemic stroke when it is administered with fasudil pharmacotherapy, but not without it."7.83Combination of early constraint-induced movement therapy and fasudil enhances motor recovery after ischemic stroke in rats. ( Bonney, E; Chen, YH; Huang, FZ; Liu, BQ; Liu, YH; Wang, HX; Zhao, Y, 2016)
"Fasudil, a Rho-kinase inhibitor, is a promising neuroprotectant against ischemic stroke; however, its low bioavailability is an obstacle to be overcome."7.83Neuroprotection against cerebral ischemia/reperfusion injury by intravenous administration of liposomal fasudil. ( Asai, T; Fukuta, T; Kikuchi, T; Koide, H; Namba, M; Oku, N; Sato, A; Shimizu, K; Yanagida, Y, 2016)
"CaMKII interacted with nNOS and regulated serine phosphorylation of nNOS during brain ischemia."7.72Brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase by Ca(2+)/calmodulin-dependent protein kinase II in rat hippocampus. ( Meng, FJ; Song, B; Yan, XB; Zhang, GY, 2004)
"The effects of an intracellular calcium antagonist fasudil (HA 1077) on protein synthesis, ion derangement, brain edema, and the neurological signs associated with focal cerebral ischemia, were investigated via a nine-hour occlusion of the left common carotid artery (CCA) in Mongolian gerbils."7.69Fasudil (HA1077), an intracellular calcium antagonist, improves neurological deficits and tissue potassium loss in focal cerebral ischemia in gerbils. ( Kondoh, Y; Mizusawa, S; Murakami, M; Nagata, K; Nakamichi, H, 1997)
"Brain ischemia was induced by the four-vessel occlusion method on Sprague-Dawley rats."5.32Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats. ( Guo, J; Meng, F; Song, B; Yan, X; Zhang, G, 2003)
"Fasudil is believed to be at least equally effective as nimodipine for the prevention of cerebral vasospasm and subsequent ischemic injury in patients undergoing surgery for subarachnoid hemorrhage (SAH)."5.15Efficacy and safety of fasudil in patients with subarachnoid hemorrhage: final results of a randomized trial of fasudil versus nimodipine. ( Guo, J; Mao, Y; Ren, Z; Wang, R; Wang, S; Xu, B; Zhang, X; Zhang, Y; Zhao, J; Zhao, K; Zhou, D; Zhou, L, 2011)
" This randomized open trial with nimodipine as the control included 72 patients who underwent subarachnoid hemorrhage surgery for ruptured cerebral aneurysm of Hunt and Hess grades I to IV."5.12Effect of fasudil hydrochloride, a protein kinase inhibitor, on cerebral vasospasm and delayed cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhage. ( Guo, J; Ren, Z; Wang, R; Wang, S; Xu, B; Zhao, J; Zhou, D; Zhou, L, 2006)
"Treatment with fasudil within 48 h of acute ischemic stroke onset significantly improved the patient's clinical outcome."5.11Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial. ( Hirai, S; Ohtomo, E; Satoh, S; Seto, M; Shibuya, M, 2005)
" To date, the only Rho-kinase inhibitor employed clinically in humans is fasudil, which has been used for the prevention of cerebral vasospasm and subsequent ischemic injury after surgery for subarachnoid hemorrhage (SAH)."4.90Pleiotropic effects of the rho-kinase inhibitor fasudil after subarachnoid hemorrhage: a review of preclinical and clinical studies. ( Asano, T; Ikegaki, I; Kawasaki, K; Satoh, S; Shibuya, M, 2014)
"Early CIMT promotes motor recovery after acute ischemic stroke when it is administered with fasudil pharmacotherapy, but not without it."3.83Combination of early constraint-induced movement therapy and fasudil enhances motor recovery after ischemic stroke in rats. ( Bonney, E; Chen, YH; Huang, FZ; Liu, BQ; Liu, YH; Wang, HX; Zhao, Y, 2016)
"Fasudil, a Rho-kinase inhibitor, is a promising neuroprotectant against ischemic stroke; however, its low bioavailability is an obstacle to be overcome."3.83Neuroprotection against cerebral ischemia/reperfusion injury by intravenous administration of liposomal fasudil. ( Asai, T; Fukuta, T; Kikuchi, T; Koide, H; Namba, M; Oku, N; Sato, A; Shimizu, K; Yanagida, Y, 2016)
"We investigated the neuroprotective effects of fasudil's active metabolite, hydroxyfasudil, a Rho-kinase inhibitor, in a rat stroke model in which endothelial damage and subsequent thrombotic occlusion were selectively induced in perforating arteries."3.76Amelioration of endothelial damage/dysfunction is a possible mechanism for the neuroprotective effects of Rho-kinase inhibitors against ischemic brain damage. ( Asano, T; Hitomi, A; Ikegaki, I; Iwasaki, M; Kawasaki, K; Mohri, M; Nakazono, O; Satoh, S, 2010)
"Recently, fasudil, a Rho kinase (ROCK) inhibitor, was reported to prevent cerebral ischemia in vivo by increasing cerebral blood flow and inhibiting inflammatory responses."3.74Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons. ( Hara, H; Iwama, T; Kotani, Y; Nakajima, Y; Nakashima, S; Shimazawa, M; Yamashita, K; Yoshimura, S, 2007)
" In this study, we assessed the temporal and spatial profiles of Rho-kianse activity and the effect of the Rho-kinase inhibitor fasudil on microcirculatory disturbances in the focal brain ischemia."3.74Rho-kinase activation in endothelial cells contributes to expansion of infarction after focal cerebral ischemia. ( Hori, M; Kaibuchi, K; Kitagawa, K; Omura-Matsuoka, E; Sasaki, T; Terasaki, Y; Todo, K; Yagita, Y, 2007)
"CaMKII interacted with nNOS and regulated serine phosphorylation of nNOS during brain ischemia."3.72Brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase by Ca(2+)/calmodulin-dependent protein kinase II in rat hippocampus. ( Meng, FJ; Song, B; Yan, XB; Zhang, GY, 2004)
"The effects of an intracellular calcium antagonist fasudil (HA 1077) on protein synthesis, ion derangement, brain edema, and the neurological signs associated with focal cerebral ischemia, were investigated via a nine-hour occlusion of the left common carotid artery (CCA) in Mongolian gerbils."3.69Fasudil (HA1077), an intracellular calcium antagonist, improves neurological deficits and tissue potassium loss in focal cerebral ischemia in gerbils. ( Kondoh, Y; Mizusawa, S; Murakami, M; Nagata, K; Nakamichi, H, 1997)
" In this review, we are introducing our new less-invasive intrathecal drug delivery system that provides an alternative and safe method to deliver therapeutic agents."2.43Safe and efficient drug delivery system with liposomes for intrathecal application of an antivasospastic drug, fasudil. ( Ishida, T; Kiwada, H; Takanashi, Y, 2006)
"To date, the pharmacologic approach to cerebral vasospasm and ischemia has been hampered in part by an inability to attain sufficiently high concentrations of drugs in the cerebrospinal fluid (CSF)."2.42[Development of drug delivery system for intrathecal administration and its therapeutic effect on cerebral vasospasm and ischemia]. ( Ishida, T, 2004)
"Hyperlipidemia is a major cardiovascular risk factor associated with progressive cerebrovascular dysfunction and diminished collateral perfusion in stroke."1.40Rho-kinase inhibition improves ischemic perfusion deficit in hyperlipidemic mice. ( Ayata, C; Huang, PL; Shin, HK, 2014)
"Chronic cerebral vasospasm was produced using a two-hemorrhage canine model."1.38Antivasospastic effects of hydroxyfasudil, a Rho-kinase inhibitor, after subarachnoid hemorrhage. ( Asano, T; Hitomi, A; Ikegaki, I; Kawasaki, K; Satoh, S; Shibuya, M; Takayasu, M; Yano, K, 2012)
"Cerebral ischemia was induced in rats by injecting 150 mug of sodium laurate into the left internal carotid artery on day 1."1.35Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model. ( Asano, T; Hitomi, A; Ikegaki, I; Satoh, S; Seto, M; Toshima, Y, 2008)
"Brain ischemia was induced by the four-vessel occlusion method on Sprague-Dawley rats."1.32Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats. ( Guo, J; Meng, F; Song, B; Yan, X; Zhang, G, 2003)
"Brain ischemia was induced by four-vessel occlusion procedure in rats."1.32Competitive binding of postsynaptic density 95 and Ca2+-calmodulin dependent protein kinase II to N-methyl-D-aspartate receptor subunit 2B in rat brain. ( Guo, J; Meng, FJ; Song, B; Yan, XB; Zhang, GY, 2004)
"Pharmacological treatment for cerebral ischemia cannot attain sufficiently high concentrations of the drugs in the cerebrospinal fluid (CSF) without precipitating systemic side effects."1.31Neuroprotection by intrathecal application of liposome-entrapped fasudil in a rat model of ischemia. ( Allen, TM; Ishida, T; Kirchmeier, MJ; Shuaib, A; Takanashi, Y, 2001)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (23.81)18.2507
2000's18 (42.86)29.6817
2010's14 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fukuta, T2
Yanagida, Y2
Asai, T2
Oku, N2
Shin, HK2
Huang, PL2
Ayata, C2
Gibson, CL1
Srivastava, K1
Sprigg, N1
Bath, PM1
Bayraktutan, U1
Satoh, S9
Ikegaki, I8
Kawasaki, K4
Asano, T10
Shibuya, M6
Huang, L2
Zhao, LB1
Yu, ZY1
He, XJ1
Ma, LP1
Li, N1
Guo, LJ1
Feng, WY1
Liu, YH1
Zhao, Y1
Huang, FZ1
Chen, YH1
Wang, HX1
Bonney, E1
Liu, BQ1
Wang, J1
Wen, CY1
Cui, CC1
Xing, Y1
Wang, M1
Qi, DS1
Zhou, C1
Han, D1
Li, PP1
Zhang, F1
Zhou, XY1
Han, M1
Di, JH1
Ye, JS1
Yu, HM1
Song, YJ1
Zhang, GY4
Sato, A1
Namba, M1
Kikuchi, T1
Koide, H1
Shimizu, K1
Feske, SK1
Sorond, FA1
Henderson, GV1
Seto, M4
Hitomi, A5
Sasaki, Y2
Liao, JK3
Nakazono, O1
Iwasaki, M1
Mohri, M1
Zhao, J2
Zhou, D2
Guo, J4
Ren, Z2
Zhou, L2
Wang, S2
Zhang, Y1
Xu, B3
Zhao, K1
Wang, R2
Mao, Y1
Zhang, X1
Takayasu, M1
Yano, K2
Jonassen, AK1
Wergeland, A1
Helgeland, E1
Mjøs, OD1
Brar, BK1
Wu, J1
Li, J1
Hu, H1
Liu, P1
Fang, Y1
Wu, D1
Song, B3
Meng, F1
Yan, X1
Zhang, G1
Meng, FJ2
Yan, XB2
Ishida, T3
Hirai, S1
Ohtomo, E1
Hao, ZB1
Pei, DS1
Guan, QH1
Rikitake, Y1
Kim, HH1
Huang, Z1
Moskowitz, MA2
Takanashi, Y2
Kiwada, H1
Salomone, S1
Potts, EM1
Lee, SW1
Millican, E1
Noma, K1
Boas, DA1
Yamashita, K1
Kotani, Y1
Nakajima, Y1
Shimazawa, M1
Yoshimura, S1
Nakashima, S1
Iwama, T1
Hara, H1
Yagita, Y1
Kitagawa, K1
Sasaki, T1
Terasaki, Y1
Todo, K1
Omura-Matsuoka, E1
Kaibuchi, K1
Hori, M1
He, Z1
Guo, L1
Wang, H1
Toshima, Y1
Zabøocka, B1
Domańska-Janik, K1
Louis, JC1
Magal, E1
Gerdes, W1
Seifert, W1
Maiese, K1
Wagner, J1
Boccone, L1
Kawamura, S1
Yasui, N1
Shirasawa, M1
Fukasawa, H1
Suzuki, Y3
Hidaka, H2
Kondoh, Y1
Mizusawa, S1
Murakami, M1
Nakamichi, H1
Nagata, K1
Nakane, H1
Yao, H1
Ibayashi, S1
Kitazono, T1
Ooboshi, H1
Uchimura, H1
Fujishima, M1
Hu, ZL1
Tan, YX1
Zhang, JP1
Qian, DH1
Kobayashi, T2
Yoshida, J1
Kirchmeier, MJ1
Shuaib, A1
Allen, TM1
Utsunomiya, T1
Tsurui, K1
Tanaka, Y1
Masuzawa, T1
Saito, M1
Yamada, T1
Ebihara, A1
Iwasa, H1
Mori, S1
Mochizuki, D1
Sugita, K1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Neuroprotective Effect of Dapsone in Patients With Aneurysmal Subarachnoid Hemorrhage: Prospective, Randomized, Double-Blinded, Placebo-Controlled, Clinical Trial[NCT05131295]Phase 349 participants (Actual)Interventional2007-09-05Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Brain Ischemia

ArticleYear
Pleiotropic effects of the rho-kinase inhibitor fasudil after subarachnoid hemorrhage: a review of preclinical and clinical studies.
    Current vascular pharmacology, 2014, Volume: 12, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Clinical Trials as Topic; Dr

2014
[Development of drug delivery system for intrathecal administration and its therapeutic effect on cerebral vasospasm and ischemia].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2004, Volume: 124, Issue:8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Delayed-Action Preparations;

2004
Safe and efficient drug delivery system with liposomes for intrathecal application of an antivasospastic drug, fasudil.
    Biological & pharmaceutical bulletin, 2006, Volume: 29, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Chemistry, Pharmaceutical; C

2006

Trials

3 trials available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Brain Ischemia

ArticleYear
Efficacy and safety of fasudil in patients with subarachnoid hemorrhage: final results of a randomized trial of fasudil versus nimodipine.
    Neurologia medico-chirurgica, 2011, Volume: 51, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Brain Ischemia; Calcium Channel Blockers

2011
Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial.
    Journal of the neurological sciences, 2005, Nov-15, Volume: 238, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Disease; Aged; Brain Ischemia; Dose-Response Re

2005
Effect of fasudil hydrochloride, a protein kinase inhibitor, on cerebral vasospasm and delayed cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhage.
    Neurologia medico-chirurgica, 2006, Volume: 46, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Brain Ischemia; Female; Humans; Male; Middle A

2006

Other Studies

36 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Brain Ischemia

ArticleYear
Co-administration of liposomal fasudil and tissue plasminogen activator ameliorated ischemic brain damage in occlusion model rats prepared by photochemically induced thrombosis.
    Biochemical and biophysical research communications, 2018, 01-01, Volume: 495, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Drug Combinations; Fibrinoly

2018
Rho-kinase inhibition improves ischemic perfusion deficit in hyperlipidemic mice.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Cerebrovascular Circulation;

2014
Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions.
    Journal of neurochemistry, 2014, Volume: 129, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Astrocytes; Blood-Brain Barrier; Blo

2014
Long-term inhibition of Rho-kinase restores the LTP impaired in chronic forebrain ischemia rats by regulating GABAA and GABAB receptors.
    Neuroscience, 2014, Sep-26, Volume: 277

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Chronic Disease; Disease Mod

2014
Combination of early constraint-induced movement therapy and fasudil enhances motor recovery after ischemic stroke in rats.
    The International journal of neuroscience, 2016, Volume: 126, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Brain Infarction; Brai

2016
Effect of activation of the Ca(2+)-permeable acid-sensing ion channel 1a on focal cerebral ischemia in diabetic rats.
    International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acid Sensing Ion Channels; Animals; Brain; Brain Isch

2015
Ischemic preconditioning protects the brain against injury via inhibiting CaMKII-nNOS signaling pathway.
    Brain research, 2016, Mar-01, Volume: 1634

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Brain Ischemia; CA1 Region, Hippo

2016
Neuroprotection against cerebral ischemia/reperfusion injury by intravenous administration of liposomal fasudil.
    International journal of pharmaceutics, 2016, Jun-15, Volume: 506, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Intravenous; Animals; Brain; Brain Is

2016
Increased leukocyte ROCK activity in patients after acute ischemic stroke.
    Brain research, 2009, Feb-27, Volume: 1257

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Blotting, Western; Brain Ischemia; Enzyme Inhib

2009
Amelioration of endothelial damage/dysfunction is a possible mechanism for the neuroprotective effects of Rho-kinase inhibitors against ischemic brain damage.
    Brain research bulletin, 2010, Jan-15, Volume: 81, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Brain Ischemia; Capillary Permeabilit

2010
Antivasospastic effects of hydroxyfasudil, a Rho-kinase inhibitor, after subarachnoid hemorrhage.
    Journal of pharmacological sciences, 2012, Volume: 118, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Viscosity; Brain Ischemia; Disease Mod

2012
Activation of corticotropin releasing factor receptor type 2 in the heart by corticotropin releasing factor offers cytoprotection against ischemic injury via PKA and PKC dependent signaling.
    Regulatory peptides, 2012, Feb-10, Volume: 174, Issue:1-3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Cell Death; Corticotropin-Re

2012
Rho-kinase inhibitor, fasudil, prevents neuronal apoptosis via the Akt activation and PTEN inactivation in the ischemic penumbra of rat brain.
    Cellular and molecular neurobiology, 2012, Volume: 32, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Brain; Brain Ischemia; Male; Neur

2012
Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats.
    Neuroscience letters, 2003, Oct-09, Volume: 349, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Calcium-Calmodulin-Dependent

2003
Competitive binding of postsynaptic density 95 and Ca2+-calmodulin dependent protein kinase II to N-methyl-D-aspartate receptor subunit 2B in rat brain.
    Acta pharmacologica Sinica, 2004, Volume: 25, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Binding, Competitive; Brain Ischemia; Calciu

2004
Brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase by Ca(2+)/calmodulin-dependent protein kinase II in rat hippocampus.
    Acta pharmacologica Sinica, 2004, Volume: 25, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Calcium-Calmodulin-Dependent

2004
Calcium/calmodulin-dependent protein kinase II (CaMKII), through NMDA receptors and L-Voltage-gated channels, modulates the serine phosphorylation of GluR6 during cerebral ischemia and early reperfusion period in rat hippocampus.
    Brain research. Molecular brain research, 2005, Oct-31, Volume: 140, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Brain Ischemia; Calciu

2005
Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.
    Stroke, 2005, Volume: 36, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Analysis of Variance; Animals; Antihypertensi

2005
Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2007, Volume: 27, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Brain Ischemia; Cerebrovascul

2007
Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons.
    Brain research, 2007, Jun-18, Volume: 1154

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Cell Survival; Dose-Response

2007
Rho-kinase activation in endothelial cells contributes to expansion of infarction after focal cerebral ischemia.
    Journal of neuroscience research, 2007, Aug-15, Volume: 85, Issue:11

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Brain Infarction; Brain Ischemia; Cal

2007
Improvement of cognitive deficit and neuronal damage in rats with chronic cerebral ischemia via relative long-term inhibition of rho-kinase.
    Cellular and molecular neurobiology, 2008, Volume: 28, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Infarction; Brain Ischemia; Cerebral C

2008
Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model.
    Brain research, 2008, Feb-08, Volume: 1193

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antipyrine; Blood Flow Velocity; Brain Ische

2008
PAF antagonist, BN52021, inhibits [3H]D-aspartate release after ischaemia in vitro.
    Neuroreport, 1994, Dec-30, Volume: 6, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aspartic Acid; Brain Ischemia; Diterpenes; E

1994
Survival-promoting and protein kinase C-regulating roles of basic FGF for hippocampal neurons exposed to phorbol ester, glutamate and ischaemia-like conditions.
    The European journal of neuroscience, 1993, Dec-01, Volume: 5, Issue:12

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Brain Ischemia; Cell Su

1993
Nitric oxide: a downstream mediator of calcium toxicity in the ischemic cascade.
    Neuroscience letters, 1994, Jan-17, Volume: 166, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Calcium; Cell Death; Cells,

1994
AT-877, a Ca2+ antagonist, fails to reduce infarct size following rat middle-cerebral artery occlusion.
    Acta neurologica Scandinavica, 1993, Volume: 88, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Glucose; Blood Pressure; Brain Ischemi

1993
Neuroprotective properties of a protein kinase inhibitor against ischaemia-induced neuronal damage in rats and gerbils.
    British journal of pharmacology, 1996, Volume: 118, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Body Water; Brain Chemistry; Brain Ischemia;

1996
Fasudil (HA1077), an intracellular calcium antagonist, improves neurological deficits and tissue potassium loss in focal cerebral ischemia in gerbils.
    Neurological research, 1997, Volume: 19, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Body Water; Brain; Brain Edema; Brain Ischem

1997
Protein kinase C modulates ischemia-induced amino acids release in the striatum of hypertensive rats.
    Brain research, 1998, Jan-26, Volume: 782, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acids; Animals; Brain Ischemia; Corpus Striatum

1998
[Effects of inhibitor of protein kinase C on brain edema formation evoked by experimental cerebral ischemia in gerbils and rats].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1996, Volume: 31, Issue:12

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Brain Edema; Brain Ischemia; Gerb

1996
Inhibition of neutrophil migration by a protein kinase inhibitor for the treatment of ischemic brain infarction.
    Japanese journal of pharmacology, 1999, Volume: 80, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Chemotaxis, Leukocyte; Enzym

1999
Neuroprotection by intrathecal application of liposome-entrapped fasudil in a rat model of ischemia.
    Neurologia medico-chirurgica, 2001, Volume: 41, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Damage, Chronic; Brain Ischemia; Cereb

2001
Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage.
    Life sciences, 2001, Aug-10, Volume: 69, Issue:12

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Brain Ischemia; Cerebral Arteries; Do

2001
Combined administration of Fasudil hydrochloride and nitroglycerin for treatment of cerebral vasospasm.
    Acta neurochirurgica. Supplement, 2001, Volume: 77

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Brain Ischemia; Drug Combinations; Female; Huma

2001
Blockade of intracellular actions of calcium may protect against ischaemic damage to the gerbil brain.
    British journal of pharmacology, 1991, Volume: 103, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Calcimycin; Calcium Channel

1991