1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Brain Edema in 7 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of an intracellular calcium antagonist fasudil (HA 1077) on protein synthesis, ion derangement, brain edema, and the neurological signs associated with focal cerebral ischemia, were investigated via a nine-hour occlusion of the left common carotid artery (CCA) in Mongolian gerbils." | 7.69 | Fasudil (HA1077), an intracellular calcium antagonist, improves neurological deficits and tissue potassium loss in focal cerebral ischemia in gerbils. ( Kondoh, Y; Mizusawa, S; Murakami, M; Nagata, K; Nakamichi, H, 1997) |
| "The effects of an intracellular calcium antagonist fasudil (HA 1077) on protein synthesis, ion derangement, brain edema, and the neurological signs associated with focal cerebral ischemia, were investigated via a nine-hour occlusion of the left common carotid artery (CCA) in Mongolian gerbils." | 3.69 | Fasudil (HA1077), an intracellular calcium antagonist, improves neurological deficits and tissue potassium loss in focal cerebral ischemia in gerbils. ( Kondoh, Y; Mizusawa, S; Murakami, M; Nagata, K; Nakamichi, H, 1997) |
| "Familial cerebral cavernous malformations (CCMs) in humans result from mutations of CCM2 (malcavernin, OSM, MGC4607), PDCD10 (CCM3), or KRIT1 (CCM1), a Rap1 effector which stabilizes endothelial cell-cell junctions." | 1.36 | Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity. ( Awad, IA; Ginsberg, MH; Shenkar, R; Stockton, RA, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fan, R | 1 |
| Enkhjargal, B | 1 |
| Camara, R | 1 |
| Yan, F | 1 |
| Gong, L | 1 |
| Tang, J | 1 |
| Chen, Y | 1 |
| Zhang, JH | 2 |
| Stockton, RA | 1 |
| Shenkar, R | 1 |
| Awad, IA | 1 |
| Ginsberg, MH | 1 |
| Fujii, M | 1 |
| Duris, K | 1 |
| Altay, O | 1 |
| Soejima, Y | 1 |
| Sherchan, P | 1 |
| Kondoh, Y | 1 |
| Mizusawa, S | 1 |
| Murakami, M | 1 |
| Nakamichi, H | 1 |
| Nagata, K | 1 |
| Hu, ZL | 1 |
| Tan, YX | 1 |
| Zhang, JP | 1 |
| Qian, DH | 1 |
| Joó, F | 2 |
| Tósaki, A | 1 |
| Oláh, Z | 1 |
| Koltai, M | 1 |
7 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Brain Edema
| Article | Year |
|---|---|
Critical role of EphA4 in early brain injury after subarachnoid hemorrhage in rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood-Brain Barrier; Brain; Brain Edema; Bra | 2017 |
Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animal Structures; Animals; Brain Edema; Capillary Pe | 2010 |
Inhibition of Rho kinase by hydroxyfasudil attenuates brain edema after subarachnoid hemorrhage in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Blood-Brain Barrier; Blotting, Weste | 2012 |
Fasudil (HA1077), an intracellular calcium antagonist, improves neurological deficits and tissue potassium loss in focal cerebral ischemia in gerbils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Body Water; Brain; Brain Edema; Brain Ischem | 1997 |
[Effects of inhibitor of protein kinase C on brain edema formation evoked by experimental cerebral ischemia in gerbils and rats].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Brain Edema; Brain Ischemia; Gerb | 1996 |
The role of endothelial second messenger's-generating system in the pathogenesis of brain oedema.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Edema; Cerebrovascular Circulation; Do | 1990 |
Inhibition by H-7 of the protein kinase C prevents formation of brain edema in Sprague-Dawley CFY rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Edema; Dose-Response Relationship, Dru | 1989 |