1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Astrocytosis studies

1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Astrocytosis

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.

Research Excerpts

Excerpt	Relevance	Reference
"Treatment with fasudil (20μM) significantly reduces the expression of GFAP in A172 cells and in spinal cord dorsal column."	1.40	Fasudil reduces GFAP expression after hypoxic injury. ( Agrawal, SK; Barnes, R; Kesherwani, V; Tarang, S, 2014)

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (33.33)	29.6817
2010's	2 (66.67)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

0 (0.00)

18.2507

2000's

1 (33.33)

29.6817

2010's

2 (66.67)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Alt, A	1
Hilgers, RD	1
Tura, A	2
Nassar, K	1
Schneider, T	1
Hueber, A	1
Januschowski, K	1
Grisanti, S	1
Lüke, J	1
Lüke, M	1
Kesherwani, V	1
Tarang, S	1
Barnes, R	1
Agrawal, SK	1
Schuettauf, F	1
Monnier, PP	1
Bartz-Schmidt, KU	1
Henke-Fahle, S	1

Studies

Alt, A

Hilgers, RD

Tura, A

Nassar, K

Schneider, T

Hueber, A

Januschowski, K

Grisanti, S

Lüke, J

Lüke, M

Kesherwani, V

Tarang, S

Barnes, R

Agrawal, SK

Schuettauf, F

Monnier, PP

Bartz-Schmidt, KU

Henke-Fahle, S

Other Studies

3 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Astrocytosis

Article	Year
The neuroprotective potential of Rho-kinase inhibition in promoting cell survival and reducing reactive gliosis in response to hypoxia in isolated bovine retina. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2013, Volume: 32, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cathepsin B; Cattle; Cell Hypoxia; Cell Surv	2013
Fasudil reduces GFAP expression after hypoxic injury. Neuroscience letters, 2014, Jul-25, Volume: 576 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Astrocytes; Cell Hypoxia; Cell Line, Tumor;	2014
Efficacy of Rho-kinase inhibition in promoting cell survival and reducing reactive gliosis in the rodent retina. Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Astrocytes; Blotting, Western; Ca	2009

Article

Year

The neuroprotective potential of Rho-kinase inhibition in promoting cell survival and reducing reactive gliosis in response to hypoxia in isolated bovine retina.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2013, Volume: 32, Issue:1

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cathepsin B; Cattle; Cell Hypoxia; Cell Surv

2013

Fasudil reduces GFAP expression after hypoxic injury.

Neuroscience letters, 2014, Jul-25, Volume: 576

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Astrocytes; Cell Hypoxia; Cell Line, Tumor;

2014

Efficacy of Rho-kinase inhibition in promoting cell survival and reducing reactive gliosis in the rodent retina.

Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:1

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Astrocytes; Blotting, Western; Ca

2009