1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Astrocytoma in 5 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We examined the regulatory mechanisms of the affinity of Gq protein-coupled histamine H(1)-receptors for histamine after histamine pretreatment in intact human U373 MG astrocytoma cells." | 7.78 | The affinity of histamine for Gq protein-coupled histamine H(1)-receptors is predominantly regulated by their internalization in human astrocytoma cells. ( Akatsu, C; Hishinuma, S; Sato, Y; Shoji, M, 2012) |
| "We investigated Ca(2+)/calmodulin (CaM)-mediated regulation of the desensitizing process of the histamine H(1) receptor-mediated increase in intracellular Ca(2+) concentration in human U373 MG astrocytoma cells." | 7.70 | Ca(2+)/calmodulin-mediated regulation of the desensitizing process in G(q) protein-coupled histamine H(1) receptor-mediated Ca(2+) responses in human U373 MG astrocytoma cells. ( Hishinuma, S; Ogura, K, 2000) |
| "We examined the regulatory mechanisms of the affinity of Gq protein-coupled histamine H(1)-receptors for histamine after histamine pretreatment in intact human U373 MG astrocytoma cells." | 3.78 | The affinity of histamine for Gq protein-coupled histamine H(1)-receptors is predominantly regulated by their internalization in human astrocytoma cells. ( Akatsu, C; Hishinuma, S; Sato, Y; Shoji, M, 2012) |
| "We investigated Ca(2+)/calmodulin (CaM)-mediated regulation of the desensitizing process of the histamine H(1) receptor-mediated increase in intracellular Ca(2+) concentration in human U373 MG astrocytoma cells." | 3.70 | Ca(2+)/calmodulin-mediated regulation of the desensitizing process in G(q) protein-coupled histamine H(1) receptor-mediated Ca(2+) responses in human U373 MG astrocytoma cells. ( Hishinuma, S; Ogura, K, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hishinuma, S | 2 |
| Sato, Y | 1 |
| Akatsu, C | 1 |
| Shoji, M | 1 |
| Van Wagoner, NJ | 1 |
| O'Keefe, GM | 1 |
| Benveniste, EN | 1 |
| Ogura, K | 1 |
| Sharma, N | 1 |
| Norman-O'Guin, K | 1 |
| Shafit-Zagardo, B | 1 |
| Hubbell, HR | 1 |
| Boyer, JE | 1 |
| Roane, P | 1 |
| Burch, RM | 1 |
5 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Astrocytoma
| Article | Year |
|---|---|
The affinity of histamine for Gq protein-coupled histamine H(1)-receptors is predominantly regulated by their internalization in human astrocytoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Astrocytoma; Binding Sites; Calcium; Calcium-Calmodul | 2012 |
Kinase inhibitors abrogate IFN-gamma-induced class II transactivator and class II MHC gene expression in astroglioma cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Astrocytoma; Brain Neoplasms; Enzyme Inhibitors; Gene | 1998 |
Ca(2+)/calmodulin-mediated regulation of the desensitizing process in G(q) protein-coupled histamine H(1) receptor-mediated Ca(2+) responses in human U373 MG astrocytoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Astrocytoma; Calcineurin Inhibitors; Calcium; Calcium | 2000 |
Phorbol-12-myristate-13-acetate (PMA) and inhibitors of protein kinase C alter glial fibrillary acidic protein (GFAP) mRNA levels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Astrocytoma; Dactinomycin; Glial Fibrillar | 1991 |
Cyclic AMP mediates the direct antiproliferative action of mismatched double-stranded RNA.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Astrocytoma; Base Composition; Car | 1991 |