1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Arthritis, Rheumatoid in 4 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pernis, AB | 1 |
| Ricker, E | 1 |
| Weng, CH | 1 |
| Rozo, C | 1 |
| Yi, W | 1 |
| He, Y | 1 |
| Xu, H | 1 |
| Liang, L | 1 |
| Zhan, Z | 1 |
| Yang, X | 1 |
| Yu, X | 1 |
| Ye, Y | 1 |
| Sun, L | 1 |
| Okamoto, H | 1 |
| Yoshio, T | 1 |
| Kaneko, H | 1 |
| Yamanaka, H | 1 |
| Migita, K | 1 |
| Eguchi, K | 1 |
| Tsukada, T | 1 |
| Kawabe, Y | 1 |
| Aoyagi, T | 1 |
| Nagataki, S | 1 |
1 review available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Rho Kinases in Autoimmune Diseases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Arthritis, Rheumatoid; Autoimmune Di | 2016 |
3 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Antiinflammatory effect of Rho kinase blockade via inhibition of NF-kappaB activation in rheumatoid arthritis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Amides; Animals; Arthritis, Experimental; Arthr | 2008 |
Inhibition of NF-kappaB signaling by fasudil as a potential therapeutic strategy for rheumatoid arthritis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arthritis, Experimental; Arthritis, Rheumato | 2010 |
The role of protein kinase in human synovial fibroblast growth.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arthritis, Rheumatoid; Benzoquinones; Calcium-Calmodu | 1995 |