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1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Anterior Choroidal Artery Infarction

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Anterior Choroidal Artery Infarction in 10 studies

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the effect of the novel intracellular calcium antagonist fasudil hydrochloride, cerebral blood flow (CBF) was measured quantitatively with positron emission tomography following the intravenous administration of fasudil in five patients with chronic cerebral infarction."9.07Effects of fasudil hydrochloride on cerebral blood flow in patients with chronic cerebral infarction. ( Hatazawa, J; Hirata, Y; Kanno, I; Kondoh, Y; Nagata, K; Satoh, Y; Shishido, F; Watahiki, Y; Yokoyama, E; Yuya, H, 1993)
"Fasudil greatly reduces the occurrence of CVS and cerebral infarction in SAH patients, significantly improves the clinical outcomes of the patients (as assessed by the Glasgow Outcome Scale)."8.88Systematic assessment and meta-analysis of the efficacy and safety of fasudil in the treatment of cerebral vasospasm in patients with subarachnoid hemorrhage. ( He, GH; Liu, GJ; Liu, Y; Luo, GJ; Wang, XL; Wang, YF; Wang, ZJ; Xu, LL; Zeng, YJ, 2012)
"significantly reduced cerebral infarction."5.37Fasudil and ozagrel in combination show neuroprotective effects on cerebral infarction after murine middle cerebral artery occlusion. ( Hamanaka, J; Hara, H; Hozumi, I; Inuzuka, T; Kawasaki, K; Koumura, A; Shimazawa, M; Tsuruma, K, 2011)
"To evaluate the effect of the novel intracellular calcium antagonist fasudil hydrochloride, cerebral blood flow (CBF) was measured quantitatively with positron emission tomography following the intravenous administration of fasudil in five patients with chronic cerebral infarction."5.07Effects of fasudil hydrochloride on cerebral blood flow in patients with chronic cerebral infarction. ( Hatazawa, J; Hirata, Y; Kanno, I; Kondoh, Y; Nagata, K; Satoh, Y; Shishido, F; Watahiki, Y; Yokoyama, E; Yuya, H, 1993)
"Fasudil greatly reduces the occurrence of CVS and cerebral infarction in SAH patients, significantly improves the clinical outcomes of the patients (as assessed by the Glasgow Outcome Scale)."4.88Systematic assessment and meta-analysis of the efficacy and safety of fasudil in the treatment of cerebral vasospasm in patients with subarachnoid hemorrhage. ( He, GH; Liu, GJ; Liu, Y; Luo, GJ; Wang, XL; Wang, YF; Wang, ZJ; Xu, LL; Zeng, YJ, 2012)
"significantly reduced cerebral infarction."1.37Fasudil and ozagrel in combination show neuroprotective effects on cerebral infarction after murine middle cerebral artery occlusion. ( Hamanaka, J; Hara, H; Hozumi, I; Inuzuka, T; Kawasaki, K; Koumura, A; Shimazawa, M; Tsuruma, K, 2011)
"Evidence that Rho-kinase is involved in cerebral infarction has accumulated."1.35Demonstration of elevation and localization of Rho-kinase activity in the brain of a rat model of cerebral infarction. ( Asano, T; Hattori, T; Ikegaki, I; Kawasaki, K; Sasaki, Y; Satoh, S; Seto, M; Tawara, S; Toshima, Y; Yano, K, 2008)
"Cerebral ischemia was induced in rats by injecting 150 mug of sodium laurate into the left internal carotid artery on day 1."1.35Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model. ( Asano, T; Hitomi, A; Ikegaki, I; Satoh, S; Seto, M; Toshima, Y, 2008)
"Pharmacological treatment for cerebral ischemia cannot attain sufficiently high concentrations of the drugs in the cerebrospinal fluid (CSF) without precipitating systemic side effects."1.31Neuroprotection by intrathecal application of liposome-entrapped fasudil in a rat model of ischemia. ( Allen, TM; Ishida, T; Kirchmeier, MJ; Shuaib, A; Takanashi, Y, 2001)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (30.00)18.2507
2000's4 (40.00)29.6817
2010's3 (30.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gibson, CL1
Srivastava, K1
Sprigg, N1
Bath, PM1
Bayraktutan, U1
Yano, K1
Kawasaki, K2
Hattori, T1
Tawara, S1
Toshima, Y2
Ikegaki, I2
Sasaki, Y1
Satoh, S2
Asano, T2
Seto, M2
Koumura, A1
Hamanaka, J1
Tsuruma, K1
Shimazawa, M1
Hozumi, I1
Inuzuka, T1
Hara, H1
Liu, GJ1
Wang, ZJ1
Wang, YF1
Xu, LL1
Wang, XL1
Liu, Y1
Luo, GJ1
He, GH1
Zeng, YJ1
Kitazono, T1
Hitomi, A1
Ohtaki, M1
Tranmer, B1
Nagata, K1
Kondoh, Y1
Satoh, Y1
Watahiki, Y1
Yokoyama, E1
Yuya, H1
Hirata, Y1
Shishido, F1
Hatazawa, J1
Kanno, I1
Takanashi, Y1
Ishida, T1
Kirchmeier, MJ1
Shuaib, A1
Allen, TM1
Shibuya, M1
Suzuki, Y1
Sugita, K1
Saito, I1
Sasaki, T1
Takakura, K1
Nagata, I1
Kikuchi, H1
Takemae, T1
Hidaka, H1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy and Safety of Cilostazol-Nimodipine Combined Therapy on Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage (aSAH): A Prospective, Randomized, Double-Blinded, Placebo-Controlled Trial[NCT04148105]Phase 4120 participants (Anticipated)Interventional2019-11-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Anterior Choroidal Artery Infarction

ArticleYear
Systematic assessment and meta-analysis of the efficacy and safety of fasudil in the treatment of cerebral vasospasm in patients with subarachnoid hemorrhage.
    European journal of clinical pharmacology, 2012, Volume: 68, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Cerebral Infarction; Humans; Middle Aged; Prot

2012
[Fasudil hydrochloride].
    Nihon rinsho. Japanese journal of clinical medicine, 2006, Oct-28, Volume: 64 Suppl 7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cerebral Infarction; Humans; Protein Kinase

2006

Trials

2 trials available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Anterior Choroidal Artery Infarction

ArticleYear
Effects of fasudil hydrochloride on cerebral blood flow in patients with chronic cerebral infarction.
    Clinical neuropharmacology, 1993, Volume: 16, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Blood Pressure; Calcium Channel Blockers; Cereb

1993
Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Results of a prospective placebo-controlled double-blind trial.
    Journal of neurosurgery, 1992, Volume: 76, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Calcium; Cerebral Infarction; Double-Bli

1992

Other Studies

6 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Anterior Choroidal Artery Infarction

ArticleYear
Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions.
    Journal of neurochemistry, 2014, Volume: 129, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Astrocytes; Blood-Brain Barrier; Blo

2014
Demonstration of elevation and localization of Rho-kinase activity in the brain of a rat model of cerebral infarction.
    European journal of pharmacology, 2008, Oct-10, Volume: 594, Issue:1-3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Activating Transcription Factor 3; Amides; Animals; B

2008
Fasudil and ozagrel in combination show neuroprotective effects on cerebral infarction after murine middle cerebral artery occlusion.
    The Journal of pharmacology and experimental therapeutics, 2011, Volume: 338, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Cerebral Infarction; Dose-R

2011
Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model.
    Brain research, 2008, Feb-08, Volume: 1193

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antipyrine; Blood Flow Velocity; Brain Ische

2008
Pretreatment of transient focal cerebral ischemia in rats with the calcium antagonist AT877.
    Stroke, 1994, Volume: 25, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Pressure; Calcium; Cerebral Arteries;

1994
Neuroprotection by intrathecal application of liposome-entrapped fasudil in a rat model of ischemia.
    Neurologia medico-chirurgica, 2001, Volume: 41, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Damage, Chronic; Brain Ischemia; Cereb

2001
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