1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Anterior Cerebral Circulation Infarction in 5 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Early CIMT promotes motor recovery after acute ischemic stroke when it is administered with fasudil pharmacotherapy, but not without it." | 7.83 | Combination of early constraint-induced movement therapy and fasudil enhances motor recovery after ischemic stroke in rats. ( Bonney, E; Chen, YH; Huang, FZ; Liu, BQ; Liu, YH; Wang, HX; Zhao, Y, 2016) |
| " To determine if a ROCK mechanism is involved in simvastatin-induced neuroprotection following embolic strokes, we used pharmacological intervention with the ROCK inhibitor, fasudil." | 7.76 | Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: synergism with a ROCK inhibitor but not the thrombolytic tissue plasminogen activator. ( Han, MK; Lapchak, PA, 2010) |
| "Early CIMT promotes motor recovery after acute ischemic stroke when it is administered with fasudil pharmacotherapy, but not without it." | 3.83 | Combination of early constraint-induced movement therapy and fasudil enhances motor recovery after ischemic stroke in rats. ( Bonney, E; Chen, YH; Huang, FZ; Liu, BQ; Liu, YH; Wang, HX; Zhao, Y, 2016) |
| " To determine if a ROCK mechanism is involved in simvastatin-induced neuroprotection following embolic strokes, we used pharmacological intervention with the ROCK inhibitor, fasudil." | 3.76 | Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: synergism with a ROCK inhibitor but not the thrombolytic tissue plasminogen activator. ( Han, MK; Lapchak, PA, 2010) |
| " In this study, we assessed the temporal and spatial profiles of Rho-kianse activity and the effect of the Rho-kinase inhibitor fasudil on microcirculatory disturbances in the focal brain ischemia." | 3.74 | Rho-kinase activation in endothelial cells contributes to expansion of infarction after focal cerebral ischemia. ( Hori, M; Kaibuchi, K; Kitagawa, K; Omura-Matsuoka, E; Sasaki, T; Terasaki, Y; Todo, K; Yagita, Y, 2007) |
| "Treatment with fasudil (1 and 10 mg/kg, n=15 each) resulted in a significant improvement in neurological deficits." | 1.31 | A new model of cerebral microthrombosis in rats and the neuroprotective effect of a Rho-kinase inhibitor. ( Asano, T; Ikegaki, I; Satoh, S; Toshima, Y, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, YH | 1 |
| Zhao, Y | 1 |
| Huang, FZ | 1 |
| Chen, YH | 1 |
| Wang, HX | 1 |
| Bonney, E | 1 |
| Liu, BQ | 1 |
| Lapchak, PA | 1 |
| Han, MK | 1 |
| Yagita, Y | 1 |
| Kitagawa, K | 1 |
| Sasaki, T | 1 |
| Terasaki, Y | 1 |
| Todo, K | 1 |
| Omura-Matsuoka, E | 1 |
| Kaibuchi, K | 1 |
| Hori, M | 1 |
| Huang, L | 1 |
| He, Z | 1 |
| Guo, L | 1 |
| Wang, H | 1 |
| Toshima, Y | 1 |
| Satoh, S | 1 |
| Ikegaki, I | 1 |
| Asano, T | 1 |
5 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Anterior Cerebral Circulation Infarction
| Article | Year |
|---|---|
Combination of early constraint-induced movement therapy and fasudil enhances motor recovery after ischemic stroke in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Brain Infarction; Brai | 2016 |
Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: synergism with a ROCK inhibitor but not the thrombolytic tissue plasminogen activator.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anticholesteremic Agents; Brain Infarction; | 2010 |
Rho-kinase activation in endothelial cells contributes to expansion of infarction after focal cerebral ischemia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Brain Infarction; Brain Ischemia; Cal | 2007 |
Improvement of cognitive deficit and neuronal damage in rats with chronic cerebral ischemia via relative long-term inhibition of rho-kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Infarction; Brain Ischemia; Cerebral C | 2008 |
A new model of cerebral microthrombosis in rats and the neuroprotective effect of a Rho-kinase inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Infarction; Carotid Artery, Internal; | 2000 |