1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Angiogenesis, Pathologic in 13 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fasudil-treated tumors also displayed fewer VM channels." | 1.42 | Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both In Vitro and In Vivo. ( Cai, XY; Chen, J; Fan, JQ; Li, ZY; Ren, JH; Wu, G; Xia, Y; Zhang, LL; Zhang, RG; Zhu, F, 2015) |
| "Malignant gliomas are characterized by high invasive potential and strong angiogenic ability." | 1.37 | HA1077, a Rho kinase inhibitor, suppresses glioma-induced angiogenesis by targeting the Rho-ROCK and the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signal pathways. ( Nakabayashi, H; Shimizu, K, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 8 (61.54) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xia, Y | 3 |
| Cai, XY | 2 |
| Fan, JQ | 2 |
| Zhang, LL | 2 |
| Ren, JH | 2 |
| Li, ZY | 2 |
| Zhang, RG | 2 |
| Zhu, F | 3 |
| Wu, G | 3 |
| Peng, W | 1 |
| Zhou, Q | 1 |
| Ao, X | 1 |
| Tang, R | 1 |
| Xiao, Z | 1 |
| Chen, W | 1 |
| Mao, K | 1 |
| Hua-Huy, T | 1 |
| Bei, Y | 1 |
| Liu, Z | 1 |
| Dinh-Xuan, AT | 1 |
| Chen, J | 1 |
| Cai, X | 1 |
| Fan, J | 1 |
| Zhang, L | 1 |
| Li, Z | 1 |
| Ren, J | 1 |
| Takata, K | 2 |
| Morishige, K | 4 |
| Takahashi, T | 2 |
| Hashimoto, K | 2 |
| Tsutsumi, S | 2 |
| Yin, L | 2 |
| Ohta, T | 2 |
| Kawagoe, J | 2 |
| Takahashi, K | 2 |
| Kurachi, H | 2 |
| Nakabayashi, H | 1 |
| Shimizu, K | 1 |
| Washida, N | 1 |
| Wakino, S | 1 |
| Tonozuka, Y | 1 |
| Homma, K | 1 |
| Tokuyama, H | 1 |
| Hara, Y | 1 |
| Hasegawa, K | 1 |
| Minakuchi, H | 1 |
| Fujimura, K | 1 |
| Hosoya, K | 1 |
| Hayashi, K | 1 |
| Itoh, H | 1 |
| Nagayoshi, M | 1 |
| Tada, Y | 1 |
| West, J | 1 |
| Ochiai, E | 1 |
| Watanabe, A | 1 |
| Toyotome, T | 1 |
| Tanabe, N | 1 |
| Takiguchi, Y | 1 |
| Shigeta, A | 1 |
| Yasuda, T | 1 |
| Shibuya, K | 1 |
| Kamei, K | 1 |
| Tatsumi, K | 1 |
| Ogata, S | 2 |
| Sawada, K | 1 |
| Mabuchi, S | 1 |
| Kawase, C | 1 |
| Sakata, M | 1 |
| Kimura, T | 1 |
| Miyata, K | 1 |
| Shimokawa, H | 1 |
| Kandabashi, T | 1 |
| Higo, T | 1 |
| Eto, Y | 1 |
| Egashira, K | 1 |
| Kaibuchi, K | 1 |
| Takeshita, A | 1 |
| Kinsella, JL | 1 |
| Grant, DS | 1 |
| Weeks, BS | 1 |
| Kleinman, HK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Study of Telmisartan (Micardis) For the Prevention of Acute Graft vs. Host Disease Post Allogeneic Hematopoietic Stem Cell Transplantation[NCT02338232] | 32 participants (Actual) | Interventional | 2015-07-07 | Terminated (stopped due to Lack of Accrual) | |||
| The Relationship of Adiponectin in Adipose Tissue, Thy-1 in Plaques, and Inflammatory[NCT02519257] | 96 participants (Actual) | Interventional | 2008-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Angiogenesis, Pathologic
| Article | Year |
|---|---|
The role of sema4D in vasculogenic mimicry formation in non-small cell lung cancer and the underlying mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; A549 Cells; Animals; Antigens, CD; Carcinoma, Non-Sma | 2019 |
Inhibition of Rho-kinase alleviates peritoneal fibrosis and angiogenesis in a rat model of peritoneal dialysis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Collagen Type I; Dialysis Solutions; | 2013 |
Fasudil inhibits prostate cancer-induced angiogenesis in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line, Tumor; Cell Movement; Cell Proliferation; | 2014 |
Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both In Vitro and In Vivo.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Cell Line, Tumor; Cell Mo | 2015 |
RhoA/ROCK pathway inhibition by fasudil suppresses the vasculogenic mimicry of U2OS osteosarcoma cells in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell | 2017 |
Fasudil-induced hypoxia-inducible factor-1alpha degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Autocrine Communication; Cell Hypoxia; Cell M | 2008 |
HA1077, a Rho kinase inhibitor, suppresses glioma-induced angiogenesis by targeting the Rho-ROCK and the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signal pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antineoplastic Agents; Blotting, Western; Brain Neopl | 2011 |
Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Anti-Infective Agents, Local; Cells, | 2011 |
Inhalation of Stachybotrys chartarum evokes pulmonary arterial remodeling in mice, attenuated by Rho-kinase inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cytokines; Disease Models, Animal; Lung; Lun | 2011 |
Fasudil inhibits vascular endothelial growth factor-induced angiogenesis in vitro and in vivo.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiogenesis Inhibitors; Animals; Apoptosis; Cell Mov | 2007 |
In vitro and in vivo assays to analyze the contribution of Rho kinase in angiogenesis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alendronate; Animals; Cell Culture Techniques; Cell M | 2008 |
Rho-kinase is involved in macrophage-mediated formation of coronary vascular lesions in pigs in vivo.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Oral; Animals; Cell Movement; Coronar | 2000 |
Protein kinase C regulates endothelial cell tube formation on basement membrane matrix, Matrigel.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blood; Cell Differentiation; Cells, Cultured; Collage | 1992 |