1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Alzheimer Disease in 10 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We show an example how DES-ncRNA can aid research on Alzheimer disease and suggest potential therapeutic role for Fasudil." | 3.85 | DES-ncRNA: A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-mining. ( Alam, T; Bajic, VB; Bajic, VP; Essack, M; Ma, L; Marchand, B; Radovanovic, A; Salhi, A; Schmeier, S; Zhang, Z, 2017) |
| "Fasudil is a Rho-kinase inhibitor that has shown therapeutic benefits in brain disorders." | 1.48 | Fasudil hydrochloride ameliorates memory deficits in rat model of streptozotocin-induced Alzheimer's disease: Involvement of PI3-kinase, eNOS and NFκB. ( Bansal, N; Kumar, M, 2018) |
| "Fasudil treatment ameliorated learning and memory deficits, accompanied by reduced Aβ deposition, Tau protein phosphorylation, and BACE expression, as well as increased PSD-95 expression in hippocampus." | 1.46 | Multitarget Therapeutic Effect of Fasudil in APP/PS1transgenic Mice. ( Gu, QF; Li, YH; Liu, CY; Ma, CG; Wang, HQ; Wang, Q; Xiao, BG; Yu, JZ; Zhang, GX, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 4 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yan, H | 1 |
| Yan, Y | 1 |
| Gao, Y | 1 |
| Zhang, N | 1 |
| Kumar, G | 1 |
| Fang, Q | 1 |
| Li, Z | 1 |
| Li, J | 1 |
| Zhang, Y | 1 |
| Song, L | 2 |
| Wang, J | 1 |
| Sun, J | 1 |
| Zhang, HT | 1 |
| Ma, CG | 3 |
| Killick, R | 2 |
| Elliott, C | 2 |
| Ribe, E | 2 |
| Broadstock, M | 2 |
| Ballard, C | 1 |
| Aarsland, D | 1 |
| Williams, G | 1 |
| Guo, MF | 1 |
| Zhang, HY | 1 |
| Zhang, PJ | 1 |
| Liu, XQ | 1 |
| Song, LJ | 1 |
| Wei, WY | 1 |
| Wang, YY | 1 |
| Mu, BT | 1 |
| Chai, Z | 2 |
| Yu, JZ | 2 |
| Wei, W | 1 |
| Wang, Y | 1 |
| Zhang, J | 1 |
| Gu, Q | 1 |
| Liu, X | 1 |
| Guo, M | 1 |
| Yu, J | 1 |
| Ma, C | 1 |
| Salhi, A | 1 |
| Essack, M | 1 |
| Alam, T | 1 |
| Bajic, VP | 1 |
| Ma, L | 1 |
| Radovanovic, A | 1 |
| Marchand, B | 1 |
| Schmeier, S | 1 |
| Zhang, Z | 1 |
| Bajic, VB | 1 |
| Kumar, M | 1 |
| Bansal, N | 1 |
| Rojo, AI | 1 |
| Xia, W | 1 |
| Morin, P | 1 |
| Semenov, M | 1 |
| Baillie, G | 1 |
| Cuadrado, A | 1 |
| Al-Shawi, R | 1 |
| Ballard, CG | 1 |
| Simons, P | 1 |
| Li, YH | 1 |
| Liu, CY | 1 |
| Wang, Q | 1 |
| Gu, QF | 1 |
| Wang, HQ | 1 |
| Zhang, GX | 1 |
| Xiao, BG | 1 |
| Klegeris, A | 1 |
| Walker, DG | 1 |
| McGeer, PL | 1 |
| Ibarreta, D | 1 |
| Urcelay, E | 1 |
| Parrilla, R | 1 |
| Ayuso, MS | 1 |
1 review available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Alzheimer Disease
| Article | Year |
|---|---|
Neurodegenerative Disease Associated Pathways in the Brains of Triple Transgenic Alzheimer's Model Mice Are Reversed Following Two Weeks of Peripheral Administration of Fasudil.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alzheimer Disease; Animals; Brain; Mice; Mice, Transg | 2023 |
9 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Alzheimer Disease
| Article | Year |
|---|---|
Transcriptome analysis of fasudil treatment in the APPswe/PSEN1dE9 transgenic (APP/PS1) mice model of Alzheimer's disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alzheimer Disease; Animals; Animals, Genetically Modi | 2022 |
Fasudil reduces β-amyloid levels and neuronal apoptosis in APP/PS1 transgenic mice via inhibition of the Nogo-A/NgR/RhoA signaling axis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Ap | 2020 |
Fasudil ameliorates cognitive deficits, oxidative stress and neuronal apoptosis via inhibiting ROCK/MAPK and activating Nrf2 signalling pathways in APP/PS1 mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alzheimer Disease; Amyloid beta-Protein Precursor; An | 2021 |
DES-ncRNA: A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-mining.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alzheimer Disease; Data Mining; Dictionaries as Topic | 2017 |
Fasudil hydrochloride ameliorates memory deficits in rat model of streptozotocin-induced Alzheimer's disease: Involvement of PI3-kinase, eNOS and NFκB.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alzheimer Disease; Animals; Disease Models, Animal; E | 2018 |
A role for APP in Wnt signalling links synapse loss with β-amyloid production.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alzheimer Disease; Amyloid beta-Protein Precursor; An | 2018 |
Multitarget Therapeutic Effect of Fasudil in APP/PS1transgenic Mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alzheimer Disease; Amyloid beta-Protein Precursor; Am | 2017 |
Interaction of Alzheimer beta-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factor-alpha.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alzheimer Disease; Amyloid beta-Peptides; Cell Line; | 1997 |
Distinct pH homeostatic features in lymphoblasts from Alzheimer's disease patients.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acid-Base Equilibrium; Aged; Alzheimer Disease; Base | 1998 |