1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Aging in 15 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 9 (60.00) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Longo, F | 1 |
| Russo, I | 1 |
| Shimshek, DR | 1 |
| Greggio, E | 1 |
| Morari, M | 1 |
| Huentelman, MJ | 1 |
| Stephan, DA | 1 |
| Talboom, J | 1 |
| Corneveaux, JJ | 1 |
| Reiman, DM | 1 |
| Gerber, JD | 1 |
| Barnes, CA | 1 |
| Alexander, GE | 1 |
| Reiman, EM | 1 |
| Bimonte-Nelson, HA | 1 |
| Lang, JA | 1 |
| Jennings, JD | 1 |
| Holowatz, LA | 1 |
| Kenney, WL | 1 |
| Xu, EZ | 1 |
| Kantores, C | 1 |
| Ivanovska, J | 1 |
| Engelberts, D | 1 |
| Kavanagh, BP | 1 |
| McNamara, PJ | 1 |
| Jankov, RP | 1 |
| Seres, I | 1 |
| Csongor, J | 1 |
| Mohácsi, A | 1 |
| Leövey, A | 1 |
| Fülöp, T | 1 |
| Zhao, WQ | 1 |
| Bennett, P | 1 |
| Rickard, N | 1 |
| Sedman, GL | 1 |
| Gibbs, ME | 1 |
| Ng, KT | 1 |
| Akopov, SE | 1 |
| Zhang, L | 1 |
| Pearce, WJ | 1 |
| Hu, HL | 1 |
| Forsey, RJ | 1 |
| Blades, TJ | 1 |
| Barratt, ME | 1 |
| Parmar, P | 1 |
| Powell, JR | 1 |
| Day, RW | 1 |
| Lai, WW | 1 |
| Klitzner, TS | 1 |
| Ignarro, LJ | 1 |
| Bradley, PM | 1 |
| Burns, BD | 1 |
| Titmuss, J | 1 |
| Webb, AC | 1 |
| Molloy, SS | 1 |
| Kennedy, MB | 1 |
| Ghoneum, M | 1 |
| Suzuki, K | 1 |
| Gollapudi, S | 1 |
| Grunstein, MM | 1 |
| Rosenberg, SM | 1 |
| Schramm, CM | 1 |
| Pawlowski, NA | 1 |
| Osborne, NN | 1 |
| Broyden, NJ | 1 |
| Barnett, NL | 1 |
| Morris, NJ | 1 |
| Friedman, E | 1 |
| Wang, HY | 1 |
15 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Aging
| Article | Year |
|---|---|
Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Analysis of Variance; Animals; Brain; Dose-Res | 2014 |
Peripheral delivery of a ROCK inhibitor improves learning and working memory.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Animals; Dose-Response Relationship, Drug; Mal | 2009 |
Reflex vasoconstriction in aged human skin increasingly relies on Rho kinase-dependent mechanisms during whole body cooling.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Age Factors; Aged; Aging; Blood Flow Velocity; Blood | 2009 |
Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Age Factors; Aging; Amides; Animals; Apoptosis; Cell | 2010 |
Age-dependent alterations of human recombinant GM-CSF effects on human granulocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Aged, 80 and over; Aging; Calcium; Cell | 1993 |
The involvement of Ca2+/calmodulin-dependent protein kinase in memory formation in day-old chicks.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Animals; Avoidance Learning; Brain Mapping; Ca | 1996 |
Regulation of Ca2+ sensitization by PKC and rho proteins in ovine cerebral arteries: effects of artery size and age.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Animals; Calcium; Cerebral Arteries; Enzyme Ac | 1998 |
Antioxidants may contribute in the fight against ageing: an in vitro model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Antioxidants; Cell Line; Child; Child, Prescho | 2000 |
Oxygen-mediated regulation of neonatal and adult rabbit aortic tension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Animals; Aorta; Arginine; Endothelium, Vascula | 1992 |
Protein kinase activity and synaptic plasticity in a chick brain slice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Animals; Chickens; Evoked Potentials; In Vitro | 1992 |
Autophosphorylation of type II Ca2+/calmodulin-dependent protein kinase in cultures of postnatal rat hippocampal slices.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Animals; Brain; Calcium; Calcium-Calmodulin-De | 1991 |
Phorbol myristate acetate corrects impaired NK function of old mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Animals; Cell Adhesion; Cytotoxicity, Immunolo | 1991 |
Mechanisms of action of endothelin 1 in maturing rabbit airway smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Aging; Animals; Dinoprostone; Eicosano | 1991 |
Protein kinase C (alpha and beta) immunoreactivity in rabbit and rat retina: effect of phorbol esters and transmitter agonists on immunoreactivity and the translocation of the enzyme from cytosolic to membrane compartments.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Aging; Alkaloids; Animals; Antibodie | 1991 |
Effect of age on brain cortical protein kinase C and its mediation of 5-hydroxytryptamine release.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Animals; Calcimycin; Calcium; Cerebral Cortex; | 1989 |