1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Age-Related Memory Disorders in 3 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fasudil is a Rho-kinase inhibitor that has shown therapeutic benefits in brain disorders." | 1.48 | Fasudil hydrochloride ameliorates memory deficits in rat model of streptozotocin-induced Alzheimer's disease: Involvement of PI3-kinase, eNOS and NFκB. ( Bansal, N; Kumar, M, 2018) |
| "Fasudil treatment ameliorated learning and memory deficits, accompanied by reduced Aβ deposition, Tau protein phosphorylation, and BACE expression, as well as increased PSD-95 expression in hippocampus." | 1.46 | Multitarget Therapeutic Effect of Fasudil in APP/PS1transgenic Mice. ( Gu, QF; Li, YH; Liu, CY; Ma, CG; Wang, HQ; Wang, Q; Xiao, BG; Yu, JZ; Zhang, GX, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kumar, M | 1 |
| Bansal, N | 1 |
| Yu, JZ | 1 |
| Li, YH | 1 |
| Liu, CY | 1 |
| Wang, Q | 1 |
| Gu, QF | 1 |
| Wang, HQ | 1 |
| Zhang, GX | 1 |
| Xiao, BG | 1 |
| Ma, CG | 1 |
| Mishima, K | 1 |
| Tsukikawa, H | 1 |
| Inada, K | 1 |
| Fujii, M | 1 |
| Iwasaki, K | 1 |
| Matsumoto, Y | 1 |
| Abe, K | 1 |
| Egawa, T | 1 |
| Fujiwara, M | 1 |
3 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Age-Related Memory Disorders
| Article | Year |
|---|---|
Fasudil hydrochloride ameliorates memory deficits in rat model of streptozotocin-induced Alzheimer's disease: Involvement of PI3-kinase, eNOS and NFκB.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alzheimer Disease; Animals; Disease Models, Animal; E | 2018 |
Multitarget Therapeutic Effect of Fasudil in APP/PS1transgenic Mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alzheimer Disease; Amyloid beta-Protein Precursor; Am | 2017 |
Ameliorative effect of vasopressin-(4-9) through vasopressin V(1A) receptor on scopolamine-induced impairments of rat spatial memory in the eight-arm radial maze.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Antidiuretic Hormone Receptor | 2001 |