Page last updated: 2024-10-28

1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Adult Spinal Muscular Atrophy

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Adult Spinal Muscular Atrophy in 2 studies

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.

Research Excerpts

ExcerptRelevanceReference
"Fasudil was administered by oral gavage from post-natal day 3 to 21 at a concentration of 30 mg/kg twice daily."1.38Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy. ( Anderson, CL; Bowerman, M; Boyer, JG; Kothary, R; Murray, LM, 2012)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hensel, N1
Baskal, S1
Walter, LM1
Brinkmann, H1
Gernert, M1
Claus, P1
Bowerman, M1
Murray, LM1
Boyer, JG1
Anderson, CL1
Kothary, R1

Other Studies

2 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Adult Spinal Muscular Atrophy

ArticleYear
ERK and ROCK functionally interact in a signaling network that is compensationally upregulated in Spinal Muscular Atrophy.
    Neurobiology of disease, 2017, Volume: 108

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzimidazoles; Cell Death; Cell Line; Cytop

2017
Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy.
    BMC medicine, 2012, Mar-07, Volume: 10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anterior Horn Cells; Disease Models, Animal;

2012