1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Acute Liver Injury, Drug-Induced in 2 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fasudil is an inhibitor of Rhoa/ROCK signaling, which is involved in anti-inflammatory and anti-injury effects." | 1.62 | Fasudil alleviates acetaminophen-induced liver injury via targeting Rhoa/ROCK signal pathway. ( Li, X; Lu, L; Meng, T; Ren, X, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ren, X | 2 |
| Meng, T | 1 |
| Li, X | 1 |
| Lu, L | 1 |
| Ikeda, H | 1 |
| Kume, Y | 1 |
| Tejima, K | 1 |
| Tomiya, T | 1 |
| Nishikawa, T | 1 |
| Watanabe, N | 1 |
| Ohtomo, N | 1 |
| Arai, M | 1 |
| Arai, C | 1 |
| Omata, M | 1 |
| Fujiwara, K | 1 |
| Yatomi, Y | 1 |
2 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Fasudil alleviates acetaminophen-induced liver injury via targeting Rhoa/ROCK signal pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetaminophen; Animals; Chemical and Drug Induced Liv | 2021 |
Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Androstadienes; Animals; Apoptosis; Carbon Tetrachlor | 2007 |