1-(3-trifluoromethylphenyl)piperazine has been researched along with Anxiety in 6 studies
1-(3-trifluoromethylphenyl)piperazine: acts as serotonin agonist; structure
1-(3-(trifluoromethyl)phenyl)piperazine : A N-arylpiperazine that is piperazine substituted by a 3-(trifluoromethyl)phenyl group at position 1. A serotonergic agonist used as a recreational drug.
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of this study was to determine the clinical effects of party pills containing benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP) when taken alone and in combination with alcohol." | 2.75 | Randomised double-blind, placebo-controlled trial of the effects of the 'party pills' BZP/TFMPP alone and in combination with alcohol. ( Aldington, S; Beasley, R; Caldwell, B; Dickson, S; Lucas, N; McDowall, J; Robinson, G; Thompson, I; Weatherall, M; Williams, G, 2010) |
| " Since the chronic chlordiazepoxide pretreatment did not prevent the hypolocomotion or hypophagia induced by mCPP at high dosage (5 mg/kg) these latter effects are unlikely to be secondary to anxiety." | 1.28 | Anxiogenic-like effects of mCPP and TFMPP in animal models are opposed by 5-HT1C receptor antagonists. ( Curzon, G; Kennett, GA; Shah, K; Whitton, P, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thompson, I | 1 |
| Williams, G | 1 |
| Caldwell, B | 1 |
| Aldington, S | 1 |
| Dickson, S | 1 |
| Lucas, N | 1 |
| McDowall, J | 1 |
| Weatherall, M | 1 |
| Robinson, G | 1 |
| Beasley, R | 1 |
| Lin, JC | 1 |
| Jan, RK | 1 |
| Kydd, RR | 1 |
| Russell, BR | 1 |
| Tokumo, K | 1 |
| Tamura, N | 1 |
| Hirai, T | 1 |
| Nishio, H | 1 |
| Setem, J | 1 |
| Pinheiro, AP | 1 |
| Motta, VA | 1 |
| Morato, S | 1 |
| Cruz, AP | 1 |
| Kennett, GA | 2 |
| Whitton, P | 1 |
| Shah, K | 1 |
| Curzon, G | 1 |
2 reviews available for 1-(3-trifluoromethylphenyl)piperazine and Anxiety
| Article | Year |
|---|---|
Subjective effects in humans following administration of party pill drugs BZP and TFMPP alone and in combination.
Topics: Affect; Anxiety; Central Nervous System Stimulants; Humans; Illicit Drugs; Piperazines | 2011 |
Mechanisms of serotonergic affect control.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Busp | 1991 |
1 trial available for 1-(3-trifluoromethylphenyl)piperazine and Anxiety
| Article | Year |
|---|---|
Randomised double-blind, placebo-controlled trial of the effects of the 'party pills' BZP/TFMPP alone and in combination with alcohol.
Topics: Adult; Akathisia, Drug-Induced; Alcohol Drinking; Anxiety; Central Nervous System Stimulants; Cross- | 2010 |
3 other studies available for 1-(3-trifluoromethylphenyl)piperazine and Anxiety
| Article | Year |
|---|---|
Effects of (Z)-3-hexenol, a major component of green odor, on anxiety-related behavior of the mouse in an elevated plus-maze test and biogenic amines and their metabolites in the brain.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Biogenic Amines; Brain; Brain Chemistry; Di | 2006 |
Ethopharmacological analysis of 5-HT ligands on the rat elevated plus-maze.
Topics: Animals; Anxiety; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Cyclic S-Oxides; Explor | 1999 |
Anxiogenic-like effects of mCPP and TFMPP in animal models are opposed by 5-HT1C receptor antagonists.
Topics: Animals; Anxiety; Drug Interactions; Feeding Behavior; Indoles; Interpersonal Relations; Male; Motor | 1989 |