Compounds > 1-(3-chlorophenyl)sulfonylpyrrolidine

1-(3-chlorophenyl)sulfonylpyrrolidine and Epilepsy

1-(3-chlorophenyl)sulfonylpyrrolidine has been researched along with Epilepsy* in 1 studies

*Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., mo [MeSH]

Other Studies

1 other study(ies) available for 1-(3-chlorophenyl)sulfonylpyrrolidine and Epilepsy

Article	Year
Simple N,N-dimethyl phenylsulfonamides show potent anticonvulsant effect in two standard epilepsy models. Bioorganic & medicinal chemistry letters, 2017, 01-01, Volume: 27, Issue:1 Optimization of the previously reported benzothiazine analogue A led to the identification of compound 1, which showed anti-convulsant activity in two golden standard animal models of seizure, the MES and scPTZ models. Structure-activity relationship investigation of compound 1 revealed compounds 2, 6 and 19 as attractive anti-epileptic drug (AED) candidates with potent anticonvulsant effect in both the MES and scPTZ models. As these compounds are structurally different from existing AEDs, determination of their mechanism of actions could provide clues to understanding current therapy-resistant seizures. Moreover, these simple phenylsulfoneamide compounds could be good starting points for searching broad spectrum AEDs by such in vivo screening. Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Epilepsy; Molecular Structure; Pentylenetetrazole; Rats; Sulfonamides	2017

Article

Year

Simple N,N-dimethyl phenylsulfonamides show potent anticonvulsant effect in two standard epilepsy models.

Bioorganic & medicinal chemistry letters, 2017, 01-01, Volume: 27, Issue:1

Optimization of the previously reported benzothiazine analogue A led to the identification of compound 1, which showed anti-convulsant activity in two golden standard animal models of seizure, the MES and scPTZ models. Structure-activity relationship investigation of compound 1 revealed compounds 2, 6 and 19 as attractive anti-epileptic drug (AED) candidates with potent anticonvulsant effect in both the MES and scPTZ models. As these compounds are structurally different from existing AEDs, determination of their mechanism of actions could provide clues to understanding current therapy-resistant seizures. Moreover, these simple phenylsulfoneamide compounds could be good starting points for searching broad spectrum AEDs by such in vivo screening.

Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Epilepsy; Molecular Structure; Pentylenetetrazole; Rats; Sulfonamides

2017