1-(3-chlorophenyl)piperazine has been researched along with Seizures in 4 studies
1-(3-chlorophenyl)piperazine: supposed metabolite of TRAZODONE; RN given refers to parent cpd; structure
1-(3-chlorophenyl)piperazine : A N-arylpiperazine that is piperazine carrying a 3-chlorophenyl substituent at position 1. It is a metabolite of the antidepressant drug trazodone.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fluoxetine, a serotonin (5-HT) reuptake inhibitor, has been documented to exert a protective action against convulsive seizures in animal models, when administered either systemically, or focally into substantia nigra." | 3.69 | The anticonvulsant action of fluoxetine in substantia nigra is dependent upon endogenous serotonin. ( Gale, K; Pasini, A; Tortorella, A, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Faingold, CL | 1 |
| Randall, M | 1 |
| Mhaskar, Y | 1 |
| Uteshev, VV | 1 |
| Pasini, A | 1 |
| Tortorella, A | 1 |
| Gale, K | 1 |
| O'Dell, LE | 1 |
| Kreifeldt, MJ | 1 |
| George, FR | 1 |
| Ritz, MC | 1 |
| Singh, L | 1 |
| Oles, RJ | 1 |
| Tricklebank, MD | 1 |
4 other studies available for 1-(3-chlorophenyl)piperazine and Seizures
| Article | Year |
|---|---|
Differences in serotonin receptor expression in the brainstem may explain the differential ability of a serotonin agonist to block seizure-induced sudden death in DBA/2 vs. DBA/1 mice.
Topics: Animals; Brain Stem; Death, Sudden; Disease Models, Animal; Dose-Response Relationship, Drug; Fluoxe | 2011 |
The anticonvulsant action of fluoxetine in substantia nigra is dependent upon endogenous serotonin.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anticonvulsants; Bicuculline; Convulsants; Fencloni | 1996 |
Serotonin(2C) receptors appear to mediate genetic sensitivity to cocaine-induced convulsions.
Topics: Animals; Cocaine; Male; Mice; Mice, Inbred C57BL; Piperazines; Pyrazines; Receptor, Serotonin, 5-HT2 | 1999 |
Modulation of seizure susceptibility in the mouse by the strychnine-insensitive glycine recognition site of the NMDA receptor/ion channel complex.
Topics: Acoustic Stimulation; Animals; Aspartic Acid; Diazepam; Injections, Intraventricular; Ion Channels; | 1990 |