1-(3-chlorophenyl)piperazine has been researched along with Panic Attacks in 13 studies
1-(3-chlorophenyl)piperazine: supposed metabolite of TRAZODONE; RN given refers to parent cpd; structure
1-(3-chlorophenyl)piperazine : A N-arylpiperazine that is piperazine carrying a 3-chlorophenyl substituent at position 1. It is a metabolite of the antidepressant drug trazodone.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The behavioral and neuroendocrine effects of meta-chlorophenylpiperazine (m-CPP), a serotonergic agonist, were compared with the effects of caffeine, an adenosine antagonist, in panic disorder patients." | 9.07 | Anxiogenic effects of m-CPP in patients with panic disorder: comparison to caffeine's anxiogenic effects. ( Geraci, MF; Klein, E; Murphy, DL; Uhde, TW; Zohar, J, 1991) |
| "Eleven (42%) of the patients with PTSD experienced yohimbine-induced panic attacks and had significantly greater increases compared with controls in anxiety, panic, and PTSD symptoms, but not in cardiovascular measurements." | 5.08 | Noradrenergic and serotonergic function in posttraumatic stress disorder. ( Bremner, JD; Charney, DS; Heninger, GR; Johnson, DR; Krystal, JH; Morgan, CA; Nagy, LM; Nicolaou, AL; Southwick, SM, 1997) |
| "The behavioral and neuroendocrine effects of meta-chlorophenylpiperazine (m-CPP), a serotonergic agonist, were compared with the effects of caffeine, an adenosine antagonist, in panic disorder patients." | 5.07 | Anxiogenic effects of m-CPP in patients with panic disorder: comparison to caffeine's anxiogenic effects. ( Geraci, MF; Klein, E; Murphy, DL; Uhde, TW; Zohar, J, 1991) |
| "Various provocative agents, including sodium lactate, carbon dioxide (CO2), caffeine, yohimbine, serotoninergic agents, and cholecystokinin (CCK), have been utilized as panicogenics in studies on healthy volunteers as well as in panic disorder patients." | 4.80 | Neurobiology of panic disorder. ( Baker, GB; Bourin, M; Bradwejn, J, 1998) |
| " Challenge studies have demonstrated that subjects with social anxiety disorder have a sensitivity to carbon dioxide, cholecystokinin, and caffeine somewhere between that of panic disorder patients and normal controls." | 4.80 | Brain mechanisms of social anxiety disorder. ( Bell, CJ; Malizia, AL; Nutt, DJ, 1998) |
| "Panic attacks were significantly more provoked in patients with PD (85%), but not in patients with gSAD (14%) as compared to healthy controls (0%)." | 2.73 | Behavioural effects of rapid intravenous administration of meta-chlorophenylpiperazine (m-CPP) in patients with generalized social anxiety disorder, panic disorder and healthy controls. ( Fiselier, J; Van der Wee, NJ; Van Veen, JF; Van Vliet, IM; Westenberg, HG, 2007) |
| "Panic attacks were significantly more provoked in patients with PD (90%) compared to healthy controls (0%)." | 2.71 | Behavioural effects of rapid intravenous administration of meta-chlorophenylpiperazine in patients with panic disorder and controls. ( Fiselier, J; van der Wee, NJ; van Megen, HJ; Westenberg, HG, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (76.92) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| van der Wee, NJ | 2 |
| Fiselier, J | 2 |
| van Megen, HJ | 1 |
| Westenberg, HG | 2 |
| Van Veen, JF | 1 |
| Van Vliet, IM | 1 |
| Germine, M | 1 |
| Goddard, AW | 1 |
| Sholomskas, DE | 1 |
| Woods, SW | 1 |
| Charney, DS | 3 |
| Heninger, GR | 2 |
| Rosenblum, LA | 1 |
| Coplan, JD | 1 |
| Friedman, S | 1 |
| Bassoff, T | 1 |
| Gorman, JM | 1 |
| Andrews, MW | 1 |
| Wetzler, S | 2 |
| Asnis, GM | 2 |
| DeLecuona, JM | 1 |
| Kalus, O | 1 |
| Krystal, JH | 2 |
| Deutsch, DN | 1 |
| Southwick, SM | 1 |
| Bremner, JD | 1 |
| Morgan, CA | 1 |
| Nicolaou, AL | 1 |
| Nagy, LM | 1 |
| Johnson, DR | 1 |
| Bourin, M | 1 |
| Baker, GB | 1 |
| Bradwejn, J | 1 |
| Nutt, DJ | 1 |
| Bell, CJ | 1 |
| Malizia, AL | 1 |
| Benjamin, J | 1 |
| Geraci, M | 1 |
| McCann, U | 1 |
| Greenberg, BD | 1 |
| Murphy, DL | 2 |
| Broocks, A | 1 |
| Bandelow, B | 1 |
| George, A | 1 |
| Jestrabeck, C | 1 |
| Opitz, M | 1 |
| Bartmann, U | 1 |
| Gleiter, CH | 1 |
| Meineke, I | 1 |
| Roed, IS | 1 |
| Rüther, E | 1 |
| Hajak, G | 1 |
| Sanderson, WC | 1 |
| Kahn, RS | 1 |
| van Praag, HM | 1 |
| Klein, E | 1 |
| Zohar, J | 1 |
| Geraci, MF | 1 |
| Uhde, TW | 1 |
3 reviews available for 1-(3-chlorophenyl)piperazine and Panic Attacks
| Article | Year |
|---|---|
The biological basis of panic disorder.
Topics: Brain; Caffeine; Carbon Dioxide; gamma-Aminobutyric Acid; Humans; Lactates; Norepinephrine; Panic Di | 1996 |
Neurobiology of panic disorder.
Topics: Caffeine; Carbon Dioxide; Cholecystokinin; Humans; Neurotransmitter Agents; Panic Disorder; Piperazi | 1998 |
Brain mechanisms of social anxiety disorder.
Topics: Animals; Brain; Caffeine; Carbon Dioxide; Cholecystokinin; Dopamine; Fear; Fenfluramine; Humans; Pan | 1998 |
7 trials available for 1-(3-chlorophenyl)piperazine and Panic Attacks
| Article | Year |
|---|---|
Behavioural effects of rapid intravenous administration of meta-chlorophenylpiperazine in patients with panic disorder and controls.
Topics: Adult; Female; Growth Hormone; Humans; Hydrocortisone; Injections, Intravenous; Male; Middle Aged; P | 2004 |
Behavioural effects of rapid intravenous administration of meta-chlorophenylpiperazine (m-CPP) in patients with generalized social anxiety disorder, panic disorder and healthy controls.
Topics: Adult; Anxiety Disorders; Female; Growth Hormone; Humans; Hydrocortisone; Injections, Intravenous; M | 2007 |
Serotonin function in panic disorder: intravenous administration of meta-chlorophenylpiperazine.
Topics: Administration, Oral; Adult; Female; Humans; Hydrocortisone; Injections, Intravenous; Male; Panic Di | 1996 |
Noradrenergic and serotonergic function in posttraumatic stress disorder.
Topics: Adult; Double-Blind Method; Humans; Hypertension; Male; Norepinephrine; Panic Disorder; Piperazines; | 1997 |
Attenuated response to m-CPP and to pentagastrin after repeated m-CPP in panic disorder.
Topics: Adult; Female; Humans; Male; Panic Disorder; Pentagastrin; Piperazines; Psychiatric Status Rating Sc | 1999 |
Functional interrelationship of serotonin and norepinephrine: cortisol response to MCPP and DMI in patients with panic disorder, patients with depression, and normal control subjects.
Topics: Adult; Depressive Disorder; Desipramine; Female; Humans; Hydrocortisone; Male; Middle Aged; Norepine | 1992 |
Anxiogenic effects of m-CPP in patients with panic disorder: comparison to caffeine's anxiogenic effects.
Topics: Adult; Anxiety Disorders; Arousal; Brain; Caffeine; Double-Blind Method; Female; Humans; Hydrocortis | 1991 |
3 other studies available for 1-(3-chlorophenyl)piperazine and Panic Attacks
| Article | Year |
|---|---|
Response to meta-chlorophenylpiperazine in panic disorder patients and healthy subjects: influence of reduction in intravenous dosage.
Topics: Adult; Anxiety; Dose-Response Relationship, Drug; Female; Heart Rate; Humans; Injections, Intravenou | 1994 |
Adverse early experiences affect noradrenergic and serotonergic functioning in adult primates.
Topics: Animals; Animals, Newborn; Behavior, Animal; Feeding Behavior; Locomotion; Macaca radiata; Male; Nor | 1994 |
Increased psychological responses and divergent neuroendocrine responses to m-CPP and ipsapirone in patients with panic disorder.
Topics: Adolescent; Adult; Female; Humans; Hydrocortisone; Hypothermia, Induced; Male; Panic Disorder; Piper | 2000 |