1-(3-chlorophenyl)piperazine has been researched along with Liver Cirrhosis in 2 studies
1-(3-chlorophenyl)piperazine: supposed metabolite of TRAZODONE; RN given refers to parent cpd; structure
1-(3-chlorophenyl)piperazine : A N-arylpiperazine that is piperazine carrying a 3-chlorophenyl substituent at position 1. It is a metabolite of the antidepressant drug trazodone.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Subjects with liver cirrhosis had about a two-fold greater systemic exposure to nefazodone and hydroxynefazodone compared with normal subjects after a single dose of nefazodone, the difference decreasing to approximately 25% at steady state." | 3.69 | Single- and multiple-dose pharmacokinetics of nefazodone in patients with hepatic cirrhosis. ( Barbhaiya, RH; Behr, DA; Greene, DS; Natarajan, CS; Sainati, SM; Shukla, UA, 1995) |
| " Serial blood samples for pharmacokinetic analysis were collected for 48 h following each dose and plasma samples were assayed for NEF, HO-NEF and mCPP by a validated HPLC method." | 1.29 | Single-dose pharmacokinetics of nefazodone in healthy young and elderly subjects and in subjects with renal or hepatic impairment. ( Barbhaiya, RH; Greene, DS; Shukla, UA, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barbhaiya, RH | 2 |
| Shukla, UA | 2 |
| Natarajan, CS | 1 |
| Behr, DA | 1 |
| Greene, DS | 2 |
| Sainati, SM | 1 |
2 other studies available for 1-(3-chlorophenyl)piperazine and Liver Cirrhosis
| Article | Year |
|---|---|
Single- and multiple-dose pharmacokinetics of nefazodone in patients with hepatic cirrhosis.
Topics: Adult; Antidepressive Agents; Dose-Response Relationship, Drug; Female; Humans; Liver Cirrhosis; Mal | 1995 |
Single-dose pharmacokinetics of nefazodone in healthy young and elderly subjects and in subjects with renal or hepatic impairment.
Topics: Administration, Oral; Adult; Age Factors; Aged; Antidepressive Agents; Female; Humans; Kidney Diseas | 1995 |