1-(3-chlorophenyl)piperazine has been researched along with Disease Models, Animal in 42 studies
1-(3-chlorophenyl)piperazine: supposed metabolite of TRAZODONE; RN given refers to parent cpd; structure
1-(3-chlorophenyl)piperazine : A N-arylpiperazine that is piperazine carrying a 3-chlorophenyl substituent at position 1. It is a metabolite of the antidepressant drug trazodone.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The doses of modulators were selected on the basis of dose-response studies." | 5.39 | Effects of agomelatine in a murine model of obsessive-compulsive disorder: interaction with meta-chlorophenylpiperazine, bicuculline, and diazepam. ( Bhutada, P; Deshmukh, P; Dixit, P; Kaulaskar, S; Thakur, K, 2013) |
| "We have proposed rewarded T-maze alternation as a model of obsessive-compulsive disorder (OCD): the serotonin agonist m-chlorophenylpiperazine (mCPP) increments persistence therein, while chronic pretreatment with selective serotonin reuptake inhibitor (SSRI fluoxetine) but not benzodiazepine or desipramine abolishes mCPP effects." | 3.74 | Dopaminergic and serotonergic modulation of persistent behaviour in the reinforced spatial alternation model of obsessive-compulsive disorder. ( Boulougouris, V; Kalogerakou, S; Kontis, D; Papadimitriou, GN; Papadopoulos, S; Papakosta, VM; Poulopoulou, C; Tsaltas, E, 2008) |
| "This model has predictive value for antimigraine drugs but cannot explain the delayed onset of efficacy of 5-HT2B receptor antagonists when clinically used for migraine prophylaxis." | 1.42 | Hypoxia facilitates neurogenic dural plasma protein extravasation in mice: a novel animal model for migraine pathophysiology. ( Andriske, M; Bäcker, I; Dlugosch, E; Hemmer, K; Hunfeld, A; Lübbert, H; Mecheri, B; Paris, F; Segelcke, D; Zhu, X, 2015) |
| " The doses of modulators were selected on the basis of dose-response studies." | 1.39 | Effects of agomelatine in a murine model of obsessive-compulsive disorder: interaction with meta-chlorophenylpiperazine, bicuculline, and diazepam. ( Bhutada, P; Deshmukh, P; Dixit, P; Kaulaskar, S; Thakur, K, 2013) |
| "desipramine) treatment (both 10 mg/kg; 20 mg/kg x 21 days)." | 1.35 | Stereotypic behaviour in the deer mouse: pharmacological validation and relevance for obsessive compulsive disorder. ( Harvey, BH; Korff, S; Stein, DJ, 2008) |
| "Present study was designed to monitor the responsiveness of 5HT (5-Hydroxytryptamine) -2C receptors following the long-term administration of haloperidol in rats." | 1.34 | Neurochemical and behavioral effects of m-CPP in a rat model of tardive dyskinesia. ( Haleem, DJ; Ikram, H; Samad, N, 2007) |
| " Drugs were subsequently tested for potential long-lasting effects on brain tissue 5-HT after repeated dosing (2." | 1.31 | Serotonin transporters, serotonin release, and the mechanism of fenfluramine neurotoxicity. ( Ayestas, MA; Baumann, MH; Dersch, CM; Partilla, JS; Rothman, RB, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (4.76) | 18.2507 |
| 2000's | 21 (50.00) | 29.6817 |
| 2010's | 18 (42.86) | 24.3611 |
| 2020's | 1 (2.38) | 2.80 |
| Authors | Studies |
|---|---|
| Adams, DR | 1 |
| Bentley, JM | 1 |
| Benwell, KR | 1 |
| Bickerdike, MJ | 1 |
| Bodkin, CD | 1 |
| Cliffe, IA | 1 |
| Dourish, CT | 2 |
| George, AR | 1 |
| Kennett, GA | 1 |
| Knight, AR | 1 |
| Malcolm, CS | 1 |
| Mansell, HL | 1 |
| Misra, A | 1 |
| Quirk, K | 1 |
| Roffey, JR | 1 |
| Vickers, SP | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Kreiss, DS | 2 |
| De Deurwaerdère, P | 1 |
| Reimer, AE | 1 |
| de Oliveira, AR | 1 |
| Diniz, JB | 1 |
| Hoexter, MQ | 1 |
| Miguel, EC | 1 |
| Milad, MR | 1 |
| Brandão, ML | 1 |
| Bhutada, P | 1 |
| Dixit, P | 1 |
| Thakur, K | 1 |
| Deshmukh, P | 1 |
| Kaulaskar, S | 1 |
| Nardo, M | 1 |
| Casarotto, PC | 1 |
| Gomes, FV | 1 |
| Guimarães, FS | 1 |
| Tucci, MC | 3 |
| Dvorkin-Gheva, A | 3 |
| Sharma, R | 1 |
| Taji, L | 2 |
| Cheon, P | 2 |
| Peel, J | 2 |
| Kirk, A | 2 |
| Szechtman, H | 3 |
| Johnson, E | 1 |
| Wong, M | 1 |
| Thompson, T | 1 |
| Grabowski-Boase, L | 1 |
| Tarantino, LM | 1 |
| Hunfeld, A | 1 |
| Segelcke, D | 1 |
| Bäcker, I | 1 |
| Mecheri, B | 1 |
| Hemmer, K | 1 |
| Dlugosch, E | 1 |
| Andriske, M | 1 |
| Paris, F | 1 |
| Zhu, X | 1 |
| Lübbert, H | 1 |
| Mazzone, CM | 1 |
| Pati, D | 1 |
| Michaelides, M | 1 |
| DiBerto, J | 1 |
| Fox, JH | 2 |
| Tipton, G | 1 |
| Anderson, C | 1 |
| Duffy, K | 1 |
| McKlveen, JM | 1 |
| Hardaway, JA | 1 |
| Magness, ST | 1 |
| Falls, WA | 2 |
| Hammack, SE | 2 |
| McElligott, ZA | 1 |
| Hurd, YL | 1 |
| Kash, TL | 1 |
| Samad, N | 3 |
| Haleem, MA | 1 |
| Haleem, DJ | 4 |
| Kontis, D | 2 |
| Boulougouris, V | 1 |
| Papakosta, VM | 1 |
| Kalogerakou, S | 1 |
| Papadopoulos, S | 1 |
| Poulopoulou, C | 1 |
| Papadimitriou, GN | 1 |
| Tsaltas, E | 2 |
| Rivera, HM | 1 |
| Santollo, J | 1 |
| Nikonova, LV | 1 |
| Eckel, LA | 1 |
| Faingold, CL | 1 |
| Randall, M | 1 |
| Mhaskar, Y | 1 |
| Uteshev, VV | 1 |
| Gan'shina, TS | 2 |
| Gorbunov, AA | 2 |
| Gnezdilova, AV | 1 |
| Kurdiumov, IN | 1 |
| Avdiunina, NI | 1 |
| Piatin, BM | 1 |
| Mirzoian, RS | 2 |
| Turilova, AI | 1 |
| Khaliq, S | 1 |
| Haider, S | 1 |
| Saleem, S | 1 |
| Memon, Z | 1 |
| Harvey, ML | 1 |
| Swallows, CL | 1 |
| Cooper, MA | 1 |
| Moxon, KA | 2 |
| Kao, T | 2 |
| Shumsky, JS | 2 |
| Coffman, CF | 1 |
| Fiacco, NR | 1 |
| Granger, JC | 1 |
| Helton, BM | 1 |
| Jackson, JC | 1 |
| Kim, LV | 1 |
| Mistry, RS | 1 |
| Mizer, TM | 1 |
| Palmer, LV | 1 |
| Vacca, JA | 1 |
| Winkler, SS | 1 |
| Zimmer, BA | 1 |
| Graham, D | 1 |
| Amodeo, S | 1 |
| Jones, N | 2 |
| Duxon, MS | 2 |
| King, SM | 2 |
| Lang, AP | 1 |
| de Angelis, L | 1 |
| Gatch, MB | 1 |
| Jakus, R | 1 |
| Graf, M | 1 |
| Juhasz, G | 1 |
| Gerber, K | 1 |
| Levay, G | 2 |
| Halasz, P | 1 |
| Bagdy, G | 1 |
| Landry, ES | 1 |
| Guertin, PA | 1 |
| Guitton, MJ | 1 |
| Dudai, Y | 1 |
| Chrysikakou, S | 1 |
| Giannou, H | 1 |
| Biba, A | 1 |
| Pallidi, S | 1 |
| Christodoulou, A | 1 |
| Maillis, A | 1 |
| Rabavilas, A | 1 |
| Leveleki, C | 1 |
| Sziray, N | 1 |
| Barsvári, B | 1 |
| Soproni, K | 1 |
| Mikics, E | 1 |
| Haller, J | 1 |
| Mamiya, T | 1 |
| Asanuma, T | 1 |
| Kawai, Y | 1 |
| Hasegawa, Y | 1 |
| Nishimura, A | 1 |
| Kumazawa, T | 1 |
| Ukai, M | 1 |
| Jacob-Vadakot, S | 1 |
| Himes, BT | 1 |
| Murray, M | 1 |
| Nowak, P | 1 |
| Bortel, A | 1 |
| Dabrowska, J | 1 |
| Oswiecimska, J | 1 |
| Drosik, M | 1 |
| Kwiecinski, A | 1 |
| Opara, J | 1 |
| Kostrzewa, RM | 1 |
| Brus, R | 1 |
| Ikram, H | 1 |
| Korff, S | 1 |
| Stein, DJ | 1 |
| Harvey, BH | 1 |
| Takeda, H | 1 |
| Sadakane, C | 1 |
| Hattori, T | 1 |
| Katsurada, T | 1 |
| Ohkawara, T | 1 |
| Nagai, K | 1 |
| Asaka, M | 1 |
| Shepherd, JK | 1 |
| Grewal, SS | 1 |
| Fletcher, A | 1 |
| Bill, DJ | 1 |
| Avoli, M | 1 |
| Barbarosie, M | 1 |
| Lücke, A | 1 |
| Nagao, T | 1 |
| Lopantsev, V | 1 |
| Köhling, R | 1 |
| Baumann, MH | 1 |
| Ayestas, MA | 1 |
| Dersch, CM | 1 |
| Partilla, JS | 1 |
| Rothman, RB | 1 |
1 review available for 1-(3-chlorophenyl)piperazine and Disease Models, Animal
| Article | Year |
|---|---|
Discriminative stimulus effects of m-chlorophenylpiperazine as a model of the role of serotonin receptors in anxiety.
Topics: Animals; Anxiety; Behavior, Animal; Discrimination, Psychological; Disease Models, Animal; Humans; P | 2003 |
41 other studies available for 1-(3-chlorophenyl)piperazine and Disease Models, Animal
| Article | Year |
|---|---|
Pyrrolo(iso)quinoline derivatives as 5-HT(2C) receptor agonists.
Topics: Animals; Anti-Obesity Agents; Disease Models, Animal; Eating; Isoquinolines; Pyrroles; Quinolines; R | 2006 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Purposeless oral activity induced by meta-chlorophenylpiperazine (m-CPP): Undefined tic-like behaviors?
Topics: Animals; Basal Ganglia; Disease Models, Animal; Dose-Response Relationship, Drug; Mouth; Movement; N | 2017 |
Fear extinction in an obsessive-compulsive disorder animal model: Influence of sex and estrous cycle.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Estrous Cycle; Extinction, Psycho | 2018 |
Effects of agomelatine in a murine model of obsessive-compulsive disorder: interaction with meta-chlorophenylpiperazine, bicuculline, and diazepam.
Topics: Acetamides; Animals; Antidepressive Agents; Behavior, Animal; Bicuculline; Diazepam; Disease Models, | 2013 |
Cannabidiol reverses the mCPP-induced increase in marble-burying behavior.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Cannabidiol; Disease Models, Animal; Dose-Response R | 2014 |
Separate mechanisms for development and performance of compulsive checking in the quinpirole sensitization rat model of obsessive-compulsive disorder (OCD).
Topics: Animals; Compulsive Behavior; Disease Models, Animal; Male; Obsessive-Compulsive Disorder; Piperazin | 2014 |
5-HT2A/C receptors do not mediate the attenuation of compulsive checking by mCPP in the quinpirole sensitization rat model of obsessive-compulsive disorder (OCD).
Topics: Animals; Compulsive Behavior; Disease Models, Animal; Male; Obsessive-Compulsive Disorder; Piperazin | 2015 |
Prototypical anxiolytics do not reduce anxiety-like behavior in the open field in C57BL/6J mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Disease Models, Animal; Humans; Mice; Mice, | 2015 |
Hypoxia facilitates neurogenic dural plasma protein extravasation in mice: a novel animal model for migraine pathophysiology.
Topics: Animals; Blood Proteins; Disease Models, Animal; Dura Mater; Female; Guinea Pigs; Hypoxia; Male; Mic | 2015 |
Acute engagement of G
Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain Mapping; Cannabinoid Receptor Antagonists; Clozapine; D | 2018 |
Behavioral effects of 1-(m-chlorophenyl)piperazine (m-CPP) in a rat model of tardive dyskinesia.
Topics: Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Dopamine Antagonists; Dyskinesia, Drug-I | 2008 |
Dopaminergic and serotonergic modulation of persistent behaviour in the reinforced spatial alternation model of obsessive-compulsive disorder.
Topics: Animals; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Fluoxetine; Ma | 2008 |
Exercise is associated with reduction in the anxiogenic effect of mCPP on acoustic startle.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Disease Models, Anim | 2008 |
Behavioral and neurochemical profile of m-CPP following exposure to single restraint stress in rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Brain Chemistry; Chromatography, High Pre | 2009 |
Estradiol increases the anorexia associated with increased 5-HT(2C) receptor activation in ovariectomized rats.
Topics: Analysis of Variance; Animals; Anorexia; Brain; Disease Models, Animal; Drug Administration Routes; | 2012 |
Differences in serotonin receptor expression in the brainstem may explain the differential ability of a serotonin agonist to block seizure-induced sudden death in DBA/2 vs. DBA/1 mice.
Topics: Animals; Brain Stem; Death, Sudden; Disease Models, Animal; Dose-Response Relationship, Drug; Fluoxe | 2011 |
[Influence of 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate on cerebral blood perfusion in rats under experimental pathology conditions].
Topics: Animals; Antioxidants; Aza Compounds; Brain; Brain Ischemia; Bridged Bicyclo Compounds, Heterocyclic | 2011 |
[Cerebrovascular and antiserotoninergic activity of the combination of tropoxin and mexidol].
Topics: Animals; Antioxidants; Aza Compounds; Brain; Brain Ischemia; Bridged Bicyclo Compounds, Heterocyclic | 2011 |
Influence of serotonergic 5-HT2C receptor antagonist mesulergine in the reversal of memory deficits induced by mCPP.
Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Ergolines; Male; Maze Learn | 2012 |
A double dissociation in the effects of 5-HT2A and 5-HT2C receptors on the acquisition and expression of conditioned defeat in Syrian hamsters.
Topics: Analysis of Variance; Animals; Conditioning, Psychological; Cricetinae; Disease Models, Animal; Domi | 2012 |
Role of cortical reorganization on the effect of 5-HT pharmacotherapy for spinal cord injury.
Topics: Animals; Animals, Newborn; Brain Mapping; Disease Models, Animal; Female; Motor Cortex; Neuronal Pla | 2013 |
Ritualistic chewing behavior induced by mCPP in the rat is an animal model of obsessive compulsive disorder.
Topics: Animals; Behavior, Animal; Clomipramine; Diazepam; Disease Models, Animal; Dopamine Antagonists; Flu | 2013 |
Effects of the serotonergic agonist mCPP on male rats in the quinpirole sensitization model of obsessive-compulsive disorder (OCD).
Topics: Animals; Behavior, Animal; Compulsive Behavior; Disease Models, Animal; Dose-Response Relationship, | 2013 |
5-HT2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed plus maze.
Topics: Aminopyridines; Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dose-Respon | 2002 |
Experimental anxiety and antiepileptics: the effects of valproate and vigabatrin in the mirrored chamber test.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Conflict, Psychological; Disease Models, Ani | 2003 |
5-HT2C receptors inhibit and 5-HT1A receptors activate the generation of spike-wave discharges in a genetic rat model of absence epilepsy.
Topics: Action Potentials; Aminopyridines; Animals; Citalopram; Disease Models, Animal; Dose-Response Relati | 2003 |
Differential effects of 5-HT1 and 5-HT2 receptor agonists on hindlimb movements in paraplegic mice.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Disease Models, Animal; Drug Interactions; Exer | 2004 |
Anxiety-like state associates with taste to produce conditioned taste aversion.
Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Central Nervous System Depressants; Conditio | 2004 |
Reinforced spatial alternation as an animal model of obsessive-compulsive disorder (OCD): investigation of 5-HT2C and 5-HT1D receptor involvement in OCD pathophysiology.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Desipramine; Diazepam; Disease Model | 2005 |
Pharmacological evaluation of the stress-induced social avoidance model of anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Brain; Buspirone; Chlordiazepoxide; Diazepam; Disea | 2006 |
Effects of soybean food pellets on m-CPP-induced anxiety model of mice.
Topics: Animal Feed; Animals; Anxiety; Disease Models, Animal; Glycine max; Male; Maze Learning; Mice; Mice, | 2006 |
Role of the 5-HT2C receptor in improving weight-supported stepping in adult rats spinalized as neonates.
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Dose-Resp | 2006 |
Amphetamine and mCPP effects on dopamine and serotonin striatal in vivo microdialysates in an animal model of hyperactivity.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5,6-Dihydroxytryptamine; Age Factors; Amphetamine; Animals; Attentio | 2007 |
Neurochemical and behavioral effects of m-CPP in a rat model of tardive dyskinesia.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Chromatography, High Pressure Liquid; Corpus Striat | 2007 |
Stereotypic behaviour in the deer mouse: pharmacological validation and relevance for obsessive compulsive disorder.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Desipramine; Disease Models, Animal; Do | 2008 |
Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism.
Topics: Acylation; Aminopyridines; Animals; Anorexia; Antineoplastic Agents; Body Weight; Chalcones; Cisplat | 2008 |
Behavioural and pharmacological characterisation of the elevated "zero-maze" as an animal model of anxiety.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Chl | 1994 |
Synchronous GABA-mediated potentials and epileptiform discharges in the rat limbic system in vitro.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Animals; Disease Models, Animal; | 1996 |
Serotonin transporters, serotonin release, and the mechanism of fenfluramine neurotoxicity.
Topics: Analysis of Variance; Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Disease | 2000 |
Ethopharmacological analysis of the unstable elevated exposed plus maze, a novel model of extreme anxiety: predictive validity and sensitivity to anxiogenic agents.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Caffeine; Ca | 2002 |