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1-(3-chlorophenyl)piperazine and Depressive Disorder, Major

1-(3-chlorophenyl)piperazine has been researched along with Depressive Disorder, Major in 3 studies

1-(3-chlorophenyl)piperazine: supposed metabolite of TRAZODONE; RN given refers to parent cpd; structure
1-(3-chlorophenyl)piperazine : A N-arylpiperazine that is piperazine carrying a 3-chlorophenyl substituent at position 1. It is a metabolite of the antidepressant drug trazodone.

Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ghaziuddin, N2
King, CA2
Welch, K1
Ghaziuddin, M2
Maes, M1
Westenberg, H1
Vandoolaeghe, E1
Demedts, P1
Wauters, A1
Neels, H1
Meltzer, HY1
Welch, KB1
Zaccagnini, J1
Weidmer-Mikhail, E1
Mellow, AM1
Greden, JF1

Trials

1 trial available for 1-(3-chlorophenyl)piperazine and Depressive Disorder, Major

ArticleYear
Effects of trazodone and fluoxetine in the treatment of major depression: therapeutic pharmacokinetic and pharmacodynamic interactions through formation of meta-chlorophenylpiperazine.
    Journal of clinical psychopharmacology, 1997, Volume: 17, Issue:5

    Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Dose-Response Rel

1997

Other Studies

2 other studies available for 1-(3-chlorophenyl)piperazine and Depressive Disorder, Major

ArticleYear
Depressed suicidal adolescent males have an altered cortisol response to a pharmacological challenge.
    Asian journal of psychiatry, 2014, Volume: 7, Issue:1

    Topics: Adolescent; Depressive Disorder, Major; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal Syst

2014
Serotonin dysregulation in adolescents with major depression: hormone response to meta-chlorophenylpiperazine (mCPP) infusion.
    Psychiatry research, 2000, Sep-11, Volume: 95, Issue:3

    Topics: Adolescent; Analysis of Variance; Case-Control Studies; Depressive Disorder, Major; Female; Growth H

2000