1-(3-chlorophenyl)piperazine has been researched along with Depressive Disorder, Major in 3 studies
1-(3-chlorophenyl)piperazine: supposed metabolite of TRAZODONE; RN given refers to parent cpd; structure
1-(3-chlorophenyl)piperazine : A N-arylpiperazine that is piperazine carrying a 3-chlorophenyl substituent at position 1. It is a metabolite of the antidepressant drug trazodone.
Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ghaziuddin, N | 2 |
| King, CA | 2 |
| Welch, K | 1 |
| Ghaziuddin, M | 2 |
| Maes, M | 1 |
| Westenberg, H | 1 |
| Vandoolaeghe, E | 1 |
| Demedts, P | 1 |
| Wauters, A | 1 |
| Neels, H | 1 |
| Meltzer, HY | 1 |
| Welch, KB | 1 |
| Zaccagnini, J | 1 |
| Weidmer-Mikhail, E | 1 |
| Mellow, AM | 1 |
| Greden, JF | 1 |
1 trial available for 1-(3-chlorophenyl)piperazine and Depressive Disorder, Major
| Article | Year |
|---|---|
Effects of trazodone and fluoxetine in the treatment of major depression: therapeutic pharmacokinetic and pharmacodynamic interactions through formation of meta-chlorophenylpiperazine.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Dose-Response Rel | 1997 |
2 other studies available for 1-(3-chlorophenyl)piperazine and Depressive Disorder, Major
| Article | Year |
|---|---|
Depressed suicidal adolescent males have an altered cortisol response to a pharmacological challenge.
Topics: Adolescent; Depressive Disorder, Major; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal Syst | 2014 |
Serotonin dysregulation in adolescents with major depression: hormone response to meta-chlorophenylpiperazine (mCPP) infusion.
Topics: Adolescent; Analysis of Variance; Case-Control Studies; Depressive Disorder, Major; Female; Growth H | 2000 |