1-(3-chlorophenyl)piperazine has been researched along with Depression in 14 studies
1-(3-chlorophenyl)piperazine: supposed metabolite of TRAZODONE; RN given refers to parent cpd; structure
1-(3-chlorophenyl)piperazine : A N-arylpiperazine that is piperazine carrying a 3-chlorophenyl substituent at position 1. It is a metabolite of the antidepressant drug trazodone.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present work was devoted to the comparative analysis of influence of chronic administration of 5-HT(2B/2C) receptors agonist - m-CPP (0,5 mg/kg, i." | 1.38 | [Involvement of some subtypes of 5-HT2-receptors in affective behavior in female rats]. ( Fedotova, IuO; Frolova, HO; Ordian, NE; Soboliev, VI, 2012) |
| "Comparative study of the effects of chronic administration of 5-HT(2A/2C)-receptors agonist (m-CPP, 0." | 1.38 | [Behavioral effects of ketanserine in prenatally stressed female rats]. ( Fedotova, IuO; Ordian, NE; Pivina, SG, 2012) |
| " The chronic administration of m-CPP at the estrous phase produced an anxiolytic effect, while at the proestrous phase, the same drug produced an anxiogenic effect." | 1.37 | [Effects of 5-HT1 and 5-HT2 serotonin receptors on anxiety- and depression-like behavior in female rats]. ( Fedotova, IuO, 2011) |
| "A comparative analysis of the influence of chronic administration of the 5-HT2B/2C receptor agonist, m-CPP (0." | 1.36 | [Behavioral effects of m-CPP and ketanserine during ovarian cycle in female rats]. ( Fedotova, IuO, 2010) |
| "Trazodone is a second-generation antidepressant with serotonin antagonist activity." | 1.35 | HPLC analysis of the antidepressant trazodone and its main metabolite m-CPP in human plasma. ( Amore, M; Colliva, C; Fanali, S; Mercolini, L; Raggi, MA, 2008) |
| " A 3-week period of repeated, but unpredictable exposure to mild stressors induced a shift to the left of the dose-response curve for mCPP-induced penile erection." | 1.29 | Effects of repeated mild stress and two antidepressant treatments on the behavioral response to 5HT1C receptor activation in rats. ( Haefely, WE; Jenck, F; Martin, JR; Moreau, JL; Perrin, S, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (35.71) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 5 (35.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fedotova, IuO | 5 |
| Ordian, NE | 3 |
| Frolova, HO | 1 |
| Soboliev, VI | 1 |
| Pivina, SG | 2 |
| Akulova, VK | 1 |
| Rajkumar, R | 1 |
| Pandey, DK | 1 |
| Mahesh, R | 1 |
| Radha, R | 1 |
| Mavanji, V | 1 |
| Meti, B | 1 |
| Datta, S | 1 |
| Mercolini, L | 1 |
| Colliva, C | 1 |
| Amore, M | 1 |
| Fanali, S | 1 |
| Raggi, MA | 1 |
| Moreau, JL | 1 |
| Jenck, F | 1 |
| Martin, JR | 1 |
| Perrin, S | 1 |
| Haefely, WE | 1 |
| Kalkman, HO | 1 |
| Coccaro, EF | 1 |
| Kavoussi, RJ | 1 |
| Trestman, RL | 1 |
| Gabriel, SM | 1 |
| Cooper, TB | 1 |
| Siever, LJ | 1 |
| Schwartz, PJ | 1 |
| Turner, EH | 1 |
| Garcia-Borreguero, D | 1 |
| Sedway, J | 1 |
| Vetticad, RG | 1 |
| Wehr, TA | 1 |
| Murphy, DL | 1 |
| Rosenthal, NE | 1 |
| Mihara, K | 1 |
| Kondo, T | 1 |
| Suzuki, A | 1 |
| Yasui-Furukori, N | 1 |
| Ono, S | 1 |
| Otani, K | 1 |
| Kaneko, S | 1 |
| Kennett, GA | 1 |
2 reviews available for 1-(3-chlorophenyl)piperazine and Depression
| Article | Year |
|---|---|
Hypersensitivity to meta-chlorophenylpiperazine (mCPP) in migraine and drug withdrawal.
Topics: Animals; Depression; Humans; Migraine Disorders; Piperazines; Rats; Serotonin Receptor Agonists; Spe | 1997 |
Mechanisms of serotonergic affect control.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Busp | 1991 |
1 trial available for 1-(3-chlorophenyl)piperazine and Depression
| Article | Year |
|---|---|
Serotonin hypothesis of winter depression: behavioral and neuroendocrine effects of the 5-HT(1A) receptor partial agonist ipsapirone in patients with seasonal affective disorder and healthy control subjects.
Topics: Adrenocorticotropic Hormone; Adult; Depression; Female; Humans; Hydrocortisone; Hypothalamo-Hypophys | 1999 |
11 other studies available for 1-(3-chlorophenyl)piperazine and Depression
| Article | Year |
|---|---|
[Involvement of some subtypes of 5-HT2-receptors in affective behavior in female rats].
Topics: Animals; Animals, Outbred Strains; Anti-Anxiety Agents; Anxiety; Depression; Estrogens; Estrus; Fema | 2012 |
[Effects of 8-OH-DPAT and m-CPP on depression-like behavior in prenatally stressed ovariectomized rats treated with low dose of 17beta-estradiol].
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Depression; Estradiol; Estrogens; | 2014 |
1-(m-Chlorophenyl)piperazine induces depressogenic-like behaviour in rodents by stimulating the neuronal 5-HT(2A) receptors: proposal of a modified rodent antidepressant assay.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Behav | 2009 |
[Behavioral effects of m-CPP and ketanserine during ovarian cycle in female rats].
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Brain; Depression; E | 2010 |
[Effects of 5-HT1 and 5-HT2 serotonin receptors on anxiety- and depression-like behavior in female rats].
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; D | 2011 |
[Behavioral effects of ketanserine in prenatally stressed female rats].
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Depression; Female; | 2012 |
Sleep-wake effects of meta-chlorophenyl piperazine and mianserin in the behaviorally depressed rat.
Topics: Animals; Behavior, Animal; Depression; Injections, Intraventricular; Male; Mianserin; Piperazines; R | 2002 |
HPLC analysis of the antidepressant trazodone and its main metabolite m-CPP in human plasma.
Topics: Acetonitriles; Antidepressive Agents; Buffers; Chromatography, High Pressure Liquid; Depression; Dru | 2008 |
Effects of repeated mild stress and two antidepressant treatments on the behavioral response to 5HT1C receptor activation in rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Depression; Dose-Response Relationship | 1993 |
Serotonin function in human subjects: intercorrelations among central 5-HT indices and aggressiveness.
Topics: Adult; Aggression; Depression; Female; Fenfluramine; Humans; Male; Middle Aged; Personality Disorder | 1997 |
Effects of genetic polymorphism of CYP1A2 inducibility on the steady-state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine in depressed Japanese patients.
Topics: Adult; Alleles; Antidepressive Agents, Second-Generation; Chromatography, High Pressure Liquid; Cyto | 2001 |