1-(3-chlorophenyl)piperazine has been researched along with Body Weight in 19 studies
1-(3-chlorophenyl)piperazine: supposed metabolite of TRAZODONE; RN given refers to parent cpd; structure
1-(3-chlorophenyl)piperazine : A N-arylpiperazine that is piperazine carrying a 3-chlorophenyl substituent at position 1. It is a metabolite of the antidepressant drug trazodone.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of the study was to compare the effects of 14 day subcutaneous infusion of the 5-HT(2C) receptor agonists, m-chlorophenylpiperazine (mCPP, 12 mg kg(-1) day(-1)) and Ro 60-0175 (36 mg kg(-1) day(-1)) and the 5-HT releasing agent and re-uptake inhibitor, d-fenfluramine (6 mg kg(-1) day(-1)), on food and water intake, body weight gain and locomotion in lean male Lister hooded rats." | 7.70 | Comparative effects of continuous infusion of mCPP, Ro 60-0175 and d-fenfluramine on food intake, water intake, body weight and locomotor activity in rats. ( Benwell, KR; Bickerdike, MJ; Dourish, CT; Kennett, GA; Porter, RH; Vickers, SP, 2000) |
| "Neuroendocrine, temperature, test-meal, and psychometric responses are reviewed following challenges with the post-synaptic 5-HT receptor agonist m-chlorophenylpiperazine (m-CPP), the 5-HT precursor L-tryptophan (L-TRP), and placebo in 12 patients with anorexia nervosa (AN) and 16 healthy controls." | 5.08 | Studies of serotonin function in anorexia nervosa. ( Brewerton, TD; Jimerson, DC, 1996) |
| "Co-administration of mCPP with leptin had an additive effect on reducing body weight in DIO mice." | 3.81 | Meta-chlorophenylpiperazine enhances leptin sensitivity in diet-induced obese mice. ( Elmquist, JK; Fukuda, M; Hinton, AO; Saito, K; Tong, Q; Wang, C; Wu, Q; Xu, P; Xu, Y; Yan, C; Yan, X; Yang, Y, 2015) |
| "Both mCPP and d-fenfluramine reduced body weight relative to vehicle-treated controls over the 28-day period." | 3.72 | Oral administration of the 5-HT2Creceptor agonist, mCPP, reduces body weight gain in rats over 28 days as a result of maintained hypophagia. ( Bickerdike, MJ; Dourish, CT; Easton, N; Kennett, GA; Vickers, SP; Webster, LJ; Wyatt, A, 2003) |
| " The aim of the study was to compare the effects of 14 day subcutaneous infusion of the 5-HT(2C) receptor agonists, m-chlorophenylpiperazine (mCPP, 12 mg kg(-1) day(-1)) and Ro 60-0175 (36 mg kg(-1) day(-1)) and the 5-HT releasing agent and re-uptake inhibitor, d-fenfluramine (6 mg kg(-1) day(-1)), on food and water intake, body weight gain and locomotion in lean male Lister hooded rats." | 3.70 | Comparative effects of continuous infusion of mCPP, Ro 60-0175 and d-fenfluramine on food intake, water intake, body weight and locomotor activity in rats. ( Benwell, KR; Bickerdike, MJ; Dourish, CT; Kennett, GA; Porter, RH; Vickers, SP, 2000) |
| " Experiment 1 characterised the dose-response profile of mCPP (0." | 1.40 | On the behavioural specificity of hypophagia induced in male rats by mCPP, naltrexone, and their combination. ( Rodgers, RJ; Wright, FL, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (21.05) | 18.7374 |
| 1990's | 6 (31.58) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wright, FL | 1 |
| Rodgers, RJ | 1 |
| Yan, C | 1 |
| Yang, Y | 1 |
| Saito, K | 1 |
| Xu, P | 1 |
| Wang, C | 1 |
| Hinton, AO | 1 |
| Yan, X | 1 |
| Wu, Q | 1 |
| Tong, Q | 1 |
| Elmquist, JK | 1 |
| Fukuda, M | 1 |
| Xu, Y | 1 |
| Nonogaki, K | 2 |
| Kaji, T | 1 |
| Rice, HB | 1 |
| Corwin, RL | 1 |
| Vickers, SP | 2 |
| Easton, N | 1 |
| Webster, LJ | 1 |
| Wyatt, A | 1 |
| Bickerdike, MJ | 2 |
| Dourish, CT | 2 |
| Kennett, GA | 2 |
| Koros, E | 1 |
| Bienkowski, P | 1 |
| Kostowski, W | 1 |
| Nozue, K | 1 |
| Oka, Y | 1 |
| Takeda, H | 1 |
| Sadakane, C | 1 |
| Hattori, T | 1 |
| Katsurada, T | 1 |
| Ohkawara, T | 1 |
| Nagai, K | 1 |
| Asaka, M | 1 |
| Hadigan, CM | 1 |
| Walsh, BT | 1 |
| Buttinger, C | 1 |
| Hollander, E | 1 |
| Brewerton, TD | 2 |
| Jimerson, DC | 2 |
| Dryden, S | 1 |
| Wang, Q | 1 |
| Frankish, HM | 1 |
| Williams, G | 1 |
| Sargent, PA | 1 |
| Sharpley, AL | 1 |
| Williams, C | 1 |
| Goodall, EM | 1 |
| Cowen, PJ | 1 |
| Kaye, WH | 1 |
| Greeno, CG | 1 |
| Moss, H | 1 |
| Fernstrom, J | 1 |
| Fernstrom, M | 1 |
| Lilenfeld, LR | 1 |
| Weltzin, TE | 1 |
| Mann, JJ | 1 |
| Benwell, KR | 1 |
| Porter, RH | 1 |
| Mueller, EA | 1 |
| Lesem, MD | 1 |
| Brandt, HA | 1 |
| Quearry, B | 1 |
| George, DT | 1 |
| Murphy, DL | 5 |
| Aulakh, CS | 4 |
| Zohar, J | 1 |
| Wozniak, KM | 1 |
| Hill, JL | 3 |
| Bagdy, G | 1 |
| Calogero, AE | 1 |
| Szemeredi, K | 1 |
| Wang, P | 1 |
3 trials available for 1-(3-chlorophenyl)piperazine and Body Weight
| Article | Year |
|---|---|
Behavioral and neuroendocrine responses to metaCPP in anorexia nervosa.
Topics: Adult; Affect; Anorexia Nervosa; Arousal; Body Mass Index; Body Weight; Double-Blind Method; Female; | 1995 |
Studies of serotonin function in anorexia nervosa.
Topics: Adolescent; Adult; Anorexia Nervosa; Body Temperature Regulation; Body Weight; Bulimia; Double-Blind | 1996 |
5-HT2C receptor activation decreases appetite and body weight in obese subjects.
Topics: Adult; Appetite; Body Weight; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Middle | 1997 |
16 other studies available for 1-(3-chlorophenyl)piperazine and Body Weight
| Article | Year |
|---|---|
On the behavioural specificity of hypophagia induced in male rats by mCPP, naltrexone, and their combination.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Eating; Feeding Behavior; Grooming; Habituat | 2014 |
Meta-chlorophenylpiperazine enhances leptin sensitivity in diet-induced obese mice.
Topics: Animals; Body Weight; Diet; Dose-Response Relationship, Drug; Leptin; Mice; Mice, Inbred C57BL; Mice | 2015 |
Hypothalamic orexin and pro-opiomelanocortin activities are essential for the anorexic effects of m-chlorophenylpiperazine in mice.
Topics: Animals; Appetite Depressants; Body Weight; Cyclobutanes; Eating; Hyperphagia; Hypothalamus; Intrace | 2010 |
mCPP-induced hypophagia in rats is unaffected by the profile of dietary unsaturated fatty acids.
Topics: Animals; Body Weight; Diet; Dietary Fats; Dose-Response Relationship, Drug; Energy Intake; Fatty Aci | 2002 |
Oral administration of the 5-HT2Creceptor agonist, mCPP, reduces body weight gain in rats over 28 days as a result of maintained hypophagia.
Topics: Administration, Oral; Animals; Body Weight; Dose-Response Relationship, Drug; Drug Administration Ro | 2003 |
Effects of 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus on ethanol discrimination in the rat.
Topics: 5,7-Dihydroxytryptamine; Animals; Body Weight; Central Nervous System Depressants; Diazepam; Discrim | 2005 |
Hyperphagia alters expression of hypothalamic 5-HT2C and 5-HT1B receptor genes and plasma des-acyl ghrelin levels in Ay mice.
Topics: Agouti Signaling Protein; Animals; Blood Glucose; Body Weight; Caloric Restriction; Eating; Fenflura | 2006 |
Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism.
Topics: Acylation; Aminopyridines; Animals; Anorexia; Antineoplastic Agents; Body Weight; Chalcones; Cisplat | 2008 |
Differential effects of the 5-HT 1B/2C receptor agonist mCPP and the 5-HT1A agonist flesinoxan on hypothalamic neuropeptide Y in the rat: evidence that NPY may mediate serotonin's effects on food intake.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Body Weight; Eating; Hormones; Hypothalamus; Male; Neurope | 1996 |
Alterations in serotonin activity and psychiatric symptoms after recovery from bulimia nervosa.
Topics: Adolescent; Adult; Affect; Body Weight; Brain Chemistry; Bulimia; Feeding Behavior; Female; Follow-U | 1998 |
Comparative effects of continuous infusion of mCPP, Ro 60-0175 and d-fenfluramine on food intake, water intake, body weight and locomotor activity in rats.
Topics: Analysis of Variance; Animals; Body Weight; Drinking; Eating; Ethylamines; Fenfluramine; Hypothalamu | 2000 |
Neuroendocrine responses to m-chlorophenylpiperazine and L-tryptophan in bulimia.
Topics: Adult; Age Factors; Body Weight; Bulimia; Circadian Rhythm; Depressive Disorder; Diagnosis, Differen | 1992 |
Long-term lithium treatment in rats attenuates m-chlorophenylpiperazine-induced decreases in food intake but not locomotor activity.
Topics: Animals; Body Weight; Eating; Lithium; Male; Motor Activity; Piperazines; Rats; Rats, Inbred Strains | 1989 |
Long-term cortisol treatment impairs behavioral and neuroendocrine responses to 5-HT1 agonists in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Animals; Body Weight; Catechola | 1989 |
Fawn hooded rats are subsensitive to the food intake suppressant effects of 5-HT agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Weight; Eating; Fenfluramine; Male; Naphthalen | 1988 |
A comparison of feeding and locomotion responses to serotonin agonists in three rat strains.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Body Weight; Buspirone; Dose-Resp | 1988 |