1-(3-chlorophenyl)piperazine has been researched along with Anxiety in 70 studies
1-(3-chlorophenyl)piperazine: supposed metabolite of TRAZODONE; RN given refers to parent cpd; structure
1-(3-chlorophenyl)piperazine : A N-arylpiperazine that is piperazine carrying a 3-chlorophenyl substituent at position 1. It is a metabolite of the antidepressant drug trazodone.
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated whether the interoceptive cues mediated by the anxiolytic benzodiazepine receptor agonist alprazolam and the anxiogenic serotonin (5-HT)(1B/2C) receptor agonist 1-(3-chlorophenyl)piperazine (mCPP) in rats are related to anxiety." | 7.70 | Discriminative stimulus properties of mCPP and alprazolam are not mediated by anxiety. ( Gommans, J; Hijzen, TH; Olivier, B; Pattij, T; van der Gugten, J, 1999) |
| " We have assessed whether pretreatment with the 5-HT3 receptor antagonist BRL 46470 (1 mg orally) attenuates the increase in anxiety induced in healthy volunteers by intravenous infusion of m-chlorophenylpiperazine (mCPP: 0." | 5.07 | The 5-HT3 antagonist, BRL 46470 does not attenuate m-chlorophenylpiperazine (mCPP)-induced changes in human volunteers. ( Cowen, PJ; Silverstone, PH, 1994) |
| "We used Fos immunocytochemistry to test the effects of four anxiogenic drugs (FG-7142, yohimbine, m-chlorophenylpiperazine [mCPP], and caffeine) on anxiety-related circuitry in rat forebrain." | 3.72 | Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs. ( Salchner, P; Sharp, T; Singewald, N, 2003) |
| "We investigated whether the interoceptive cues mediated by the anxiolytic benzodiazepine receptor agonist alprazolam and the anxiogenic serotonin (5-HT)(1B/2C) receptor agonist 1-(3-chlorophenyl)piperazine (mCPP) in rats are related to anxiety." | 3.70 | Discriminative stimulus properties of mCPP and alprazolam are not mediated by anxiety. ( Gommans, J; Hijzen, TH; Olivier, B; Pattij, T; van der Gugten, J, 1999) |
| " mCPP's elimination half-life ranged from 2." | 2.71 | Pharmacokinetics of m-chlorophenylpiperazine after intravenous and oral administration in healthy male volunteers: implication for the pharmacodynamic profile. ( Bagli, M; Feuchtl, A; Frahnert, C; Kölsch, H; Kühn, KU; Rao, ML; Stephan, R, 2004) |
| "Ondansetron pretreatment significantly reduced their plasma cortisol response to m-CPP without affecting the other plasma hormone responses." | 2.68 | Behavioral, physiological and neuroendocrine responses in healthy volunteers to m-chlorophenylpiperazine (m-CPP) with and without ondansetron pretreatment. ( Baldemore, D; Briggs, NC; Broocks, A; Canter, SK; Hill, JL; Murphy, DL; Pigott, TA; Tolliver, TJ, 1997) |
| " Nonetheless, similar elevations in peak plasma cortisol and prolactin concentrations were obtained with the two dosage regimens, and temperature elevations were greater after oral m-CPP." | 2.66 | Comparative anxiogenic, neuroendocrine, and other physiologic effects of m-chlorophenylpiperazine given intravenously or orally to healthy volunteers. ( Hill, JL; Jacobsen, FM; Mueller, EA; Murphy, DL; Tolliver, TJ, 1989) |
| " Chronic administration of imipramine (15 mg/kg, ip, 21 days) caused an anxiolytic effect in the elevated T-maze and light-dark transition tests, which was not blocked by previous infusion of SB-242084 into the DH." | 1.51 | Role of 5-HT2C receptors of the dorsal hippocampus in the modulation of anxiety- and panic-related defensive responses in rats. ( de Andrade, TGCS; Hernandes, PM; Sant'Ana, AB; Vicente, MA; Vilela-Costa, HH; Zangrossi, H, 2019) |
| "When combined with sleep deprivation, there was a higher availability of drug in plasma levels." | 1.40 | Anxiety-like effects of meta-chlorophenylpiperazine in paradoxically sleep-deprived mice. ( Alvarenga, TA; Andersen, ML; Carvalho, FR; Costa, JL; Freitas, D; Frussa-Filho, R; Fukushiro, DF; Lanaro, R; Mári-Kawamoto, E; Nozoe, KT; Polesel, DN; Saito, LP; Tavares, MF; Tufik, S, 2014) |
| "The present work was devoted to the comparative analysis of influence of chronic administration of 5-HT(2B/2C) receptors agonist - m-CPP (0,5 mg/kg, i." | 1.38 | [Involvement of some subtypes of 5-HT2-receptors in affective behavior in female rats]. ( Fedotova, IuO; Frolova, HO; Ordian, NE; Soboliev, VI, 2012) |
| "Comparative study of the effects of chronic administration of 5-HT(2A/2C)-receptors agonist (m-CPP, 0." | 1.38 | [Behavioral effects of ketanserine in prenatally stressed female rats]. ( Fedotova, IuO; Ordian, NE; Pivina, SG, 2012) |
| " The chronic administration of m-CPP at the estrous phase produced an anxiolytic effect, while at the proestrous phase, the same drug produced an anxiogenic effect." | 1.37 | [Effects of 5-HT1 and 5-HT2 serotonin receptors on anxiety- and depression-like behavior in female rats]. ( Fedotova, IuO, 2011) |
| "A comparative analysis of the influence of chronic administration of the 5-HT2B/2C receptor agonist, m-CPP (0." | 1.36 | [Behavioral effects of m-CPP and ketanserine during ovarian cycle in female rats]. ( Fedotova, IuO, 2010) |
| " Since the chronic chlordiazepoxide pretreatment did not prevent the hypolocomotion or hypophagia induced by mCPP at high dosage (5 mg/kg) these latter effects are unlikely to be secondary to anxiety." | 1.28 | Anxiogenic-like effects of mCPP and TFMPP in animal models are opposed by 5-HT1C receptor antagonists. ( Curzon, G; Kennett, GA; Shah, K; Whitton, P, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (7.14) | 18.7374 |
| 1990's | 26 (37.14) | 18.2507 |
| 2000's | 23 (32.86) | 29.6817 |
| 2010's | 15 (21.43) | 24.3611 |
| 2020's | 1 (1.43) | 2.80 |
| Authors | Studies |
|---|---|
| Lopes, LT | 1 |
| Canto-de-Souza, L | 1 |
| Baptista-de-Souza, D | 1 |
| de Souza, RR | 1 |
| Nunes-de-Souza, RL | 3 |
| Canto-de-Souza, A | 2 |
| Zhang, N | 1 |
| Zhang, L | 1 |
| Feng, L | 1 |
| Yao, L | 1 |
| Sant'Ana, AB | 1 |
| Vilela-Costa, HH | 1 |
| Vicente, MA | 1 |
| Hernandes, PM | 1 |
| de Andrade, TGCS | 1 |
| Zangrossi, H | 1 |
| Fedotova, IuO | 4 |
| Ordian, NE | 2 |
| Frolova, HO | 1 |
| Soboliev, VI | 1 |
| Arrant, AE | 1 |
| Coburn, E | 1 |
| Jacobsen, J | 1 |
| Kuhn, CM | 1 |
| Polesel, DN | 1 |
| Fukushiro, DF | 1 |
| Andersen, ML | 1 |
| Nozoe, KT | 1 |
| Mári-Kawamoto, E | 1 |
| Saito, LP | 1 |
| Carvalho, FR | 1 |
| Alvarenga, TA | 1 |
| Freitas, D | 1 |
| Tufik, S | 1 |
| Frussa-Filho, R | 1 |
| Lanaro, R | 1 |
| Costa, JL | 1 |
| Tavares, MF | 1 |
| Thompson, T | 1 |
| Grabowski-Boase, L | 1 |
| Tarantino, LM | 1 |
| Lee, C | 1 |
| Verbeek, E | 1 |
| Doyle, R | 1 |
| Bateson, M | 1 |
| Mazzone, CM | 1 |
| Pati, D | 1 |
| Michaelides, M | 1 |
| DiBerto, J | 1 |
| Fox, JH | 2 |
| Tipton, G | 1 |
| Anderson, C | 1 |
| Duffy, K | 1 |
| McKlveen, JM | 1 |
| Hardaway, JA | 1 |
| Magness, ST | 1 |
| Falls, WA | 2 |
| Hammack, SE | 2 |
| McElligott, ZA | 1 |
| Hurd, YL | 1 |
| Kash, TL | 1 |
| Samad, N | 1 |
| Haleem, MA | 1 |
| Haleem, DJ | 1 |
| Kast, RE | 1 |
| Andó, RD | 1 |
| Adori, C | 1 |
| Kirilly, E | 1 |
| Molnár, E | 1 |
| Kovács, GG | 1 |
| Ferrington, L | 1 |
| Kelly, PA | 1 |
| Bagdy, G | 2 |
| Bijlsma, EY | 1 |
| de Jongh, R | 1 |
| Olivier, B | 2 |
| Groenink, L | 1 |
| Umhau, JC | 1 |
| Schwandt, ML | 1 |
| Usala, J | 1 |
| Geyer, C | 1 |
| Singley, E | 1 |
| George, DT | 2 |
| Heilig, M | 1 |
| Moya, PR | 1 |
| Fox, MA | 1 |
| Jensen, CL | 1 |
| Laporte, JL | 1 |
| French, HT | 1 |
| Wendland, JR | 1 |
| Murphy, DL | 6 |
| Pivina, SG | 1 |
| Singewald, N | 1 |
| Salchner, P | 1 |
| Sharp, T | 1 |
| Lang, AP | 1 |
| de Angelis, L | 1 |
| Gatch, MB | 2 |
| Takamatsu, H | 1 |
| Noda, A | 1 |
| Murakami, Y | 1 |
| Tatsumi, M | 1 |
| Ichise, R | 1 |
| Nishimura, S | 1 |
| Feuchtl, A | 1 |
| Bagli, M | 1 |
| Stephan, R | 1 |
| Frahnert, C | 1 |
| Kölsch, H | 1 |
| Kühn, KU | 2 |
| Rao, ML | 2 |
| Joe, AY | 1 |
| Meyer, K | 1 |
| Reichmann, K | 1 |
| Maier, W | 1 |
| Reinhardt, MJ | 1 |
| Biersack, HJ | 1 |
| Quednow, BB | 1 |
| Guitton, MJ | 2 |
| Dudai, Y | 1 |
| Bert, B | 1 |
| Felicio, LF | 1 |
| Fink, H | 2 |
| Nasello, AG | 1 |
| Voigt, JP | 1 |
| Hörtnagl, H | 1 |
| Rex, A | 1 |
| van Hove, L | 1 |
| Bader, M | 1 |
| D'Souza, DC | 1 |
| Gil, RB | 1 |
| Zuzarte, E | 1 |
| MacDougall, LM | 1 |
| Donahue, L | 1 |
| Ebersole, JS | 1 |
| Boutros, NN | 1 |
| Cooper, T | 1 |
| Seibyl, J | 1 |
| Krystal, JH | 3 |
| Pujol, R | 1 |
| Puel, JL | 1 |
| Mamiya, T | 1 |
| Asanuma, T | 1 |
| Kawai, Y | 1 |
| Hasegawa, Y | 1 |
| Nishimura, A | 1 |
| Kumazawa, T | 1 |
| Ukai, M | 1 |
| Cui, XY | 1 |
| Zhao, X | 1 |
| Chu, QP | 1 |
| Chen, BQ | 1 |
| Zhang, YH | 1 |
| Hackler, EA | 1 |
| Turner, GH | 1 |
| Gresch, PJ | 1 |
| Sengupta, S | 1 |
| Deutch, AY | 1 |
| Avison, MJ | 1 |
| Gore, JC | 1 |
| Sanders-Bush, E | 1 |
| Cornélio, AM | 1 |
| Nunes-de-Souza, V | 1 |
| Rodgers, RJ | 1 |
| Goodman, WK | 2 |
| McDougle, CJ | 1 |
| Price, LH | 2 |
| Barr, LC | 1 |
| Hills, OF | 1 |
| Caplik, JF | 1 |
| Charney, DS | 5 |
| Heninger, GR | 4 |
| Germine, M | 1 |
| Goddard, AW | 1 |
| Sholomskas, DE | 1 |
| Woods, SW | 3 |
| Silverstone, PH | 2 |
| Rue, JE | 1 |
| Franklin, M | 1 |
| Hallis, K | 1 |
| Camplin, G | 1 |
| Laver, D | 1 |
| Cowen, PJ | 2 |
| Kennedy, AJ | 1 |
| Gibson, EL | 1 |
| O'Connell, MT | 1 |
| Curzon, G | 5 |
| Shepherd, JK | 1 |
| Grewal, SS | 1 |
| Fletcher, A | 1 |
| Bill, DJ | 1 |
| Dourish, CT | 1 |
| Sevy, S | 1 |
| Brown, SL | 1 |
| Wetzler, S | 2 |
| Kotler, M | 1 |
| Molcho, A | 1 |
| Plutchik, R | 1 |
| van Praag, HM | 2 |
| Webb, E | 1 |
| Cooney, N | 1 |
| Kranzler, HR | 1 |
| Benjamin, J | 1 |
| Greenberg, BD | 1 |
| Benkelfat, C | 1 |
| Rawlings, RR | 1 |
| Eckardt, MJ | 1 |
| Phillips, MJ | 1 |
| Nutt, DJ | 1 |
| Wynne, D | 1 |
| Linnoila, M | 1 |
| Bilkei-Gorzó, A | 3 |
| Gyertyán, I | 3 |
| Szabados, T | 1 |
| Broocks, A | 2 |
| Briggs, NC | 1 |
| Pigott, TA | 1 |
| Hill, JL | 2 |
| Canter, SK | 1 |
| Tolliver, TJ | 2 |
| Baldemore, D | 1 |
| Buydens-Branchey, L | 1 |
| Branchey, M | 1 |
| Fergeson, P | 1 |
| Hudson, J | 1 |
| McKernin, C | 1 |
| Lévay, G | 1 |
| Hollander, E | 1 |
| Kwon, J | 1 |
| Weiller, F | 1 |
| Cohen, L | 1 |
| Stein, DJ | 1 |
| DeCaria, C | 1 |
| Liebowitz, M | 1 |
| Simeon, D | 1 |
| Leone, M | 1 |
| Attanasio, A | 1 |
| Croci, D | 1 |
| Ferraris, A | 1 |
| D'Amico, D | 1 |
| Grazzi, L | 1 |
| Nespolo, A | 1 |
| Bussone, G | 1 |
| Meyer, T | 1 |
| George, A | 1 |
| Hillmer-Vogel, U | 1 |
| Meyer, D | 1 |
| Bandelow, B | 1 |
| Hajak, G | 1 |
| Bartmann, U | 1 |
| Gleiter, CH | 1 |
| Rüther, E | 1 |
| Heslop, KE | 1 |
| Gommans, J | 1 |
| Hijzen, TH | 1 |
| Pattij, T | 1 |
| van der Gugten, J | 1 |
| McCann, UD | 1 |
| Eligulashvili, V | 1 |
| Mertl, M | 1 |
| Ricaurte, GA | 1 |
| Jung, ME | 1 |
| Wallis, CJ | 1 |
| Lal, H | 1 |
| Erzegovesi, S | 1 |
| Martucci, L | 1 |
| Henin, M | 1 |
| Bellodi, L | 1 |
| Graf, M | 1 |
| Anheuer, ZE | 1 |
| Modos, EA | 1 |
| Kantor, S | 1 |
| Jones, N | 1 |
| Duxon, MS | 1 |
| King, SM | 1 |
| Kennett, GA | 3 |
| Seibyl, JP | 1 |
| D'Amico, C | 1 |
| Griebel, G | 1 |
| Misslin, R | 1 |
| Pawlowski, M | 1 |
| Vogel, E | 1 |
| Whitton, P | 2 |
| Mueller, EA | 1 |
| Jacobsen, FM | 1 |
| Shah, K | 1 |
| Kahn, RS | 1 |
| Asnis, GM | 1 |
| Smith, TM | 1 |
| Suckow, RF | 1 |
3 reviews available for 1-(3-chlorophenyl)piperazine and Anxiety
| Article | Year |
|---|---|
Discriminative stimulus effects of m-chlorophenylpiperazine as a model of the role of serotonin receptors in anxiety.
Topics: Animals; Anxiety; Behavior, Animal; Discrimination, Psychological; Disease Models, Animal; Humans; P | 2003 |
Mechanisms of serotonergic affect control.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Busp | 1991 |
m-CPP: a tool for studying behavioural responses associated with 5-HT1c receptors.
Topics: Animals; Anxiety; Behavior, Animal; Humans; Piperazines; Receptors, Serotonin | 1990 |
19 trials available for 1-(3-chlorophenyl)piperazine and Anxiety
| Article | Year |
|---|---|
Pharmacologically induced alcohol craving in treatment seeking alcoholics correlates with alcoholism severity, but is insensitive to acamprosate.
Topics: Acamprosate; Adrenergic alpha-2 Receptor Antagonists; Adult; Alcohol Deterrents; Alcohol-Induced Dis | 2011 |
Pharmacokinetics of m-chlorophenylpiperazine after intravenous and oral administration in healthy male volunteers: implication for the pharmacodynamic profile.
Topics: Administration, Oral; Adrenocorticotropic Hormone; Adult; Anxiety; Auditory Perception; Dizziness; D | 2004 |
Neuroimaging and 5-HT2C receptor polymorphism: a HMPAO-SPECT study in healthy male probands using mCPP-challenge of the 5-HT2C receptor.
Topics: Adult; Anxiety; Brain; Brain Mapping; Cerebrovascular Circulation; Cysteine; Demography; Double-Blin | 2004 |
gamma-Aminobutyric acid-serotonin interactions in healthy men: implications for network models of psychosis and dissociation.
Topics: Analysis of Variance; Anxiety; Cross-Over Studies; Dissociative Disorders; Double-Blind Method; Drug | 2006 |
m-Chlorophenylpiperazine in patients with obsessive-compulsive disorder: absence of symptom exacerbation.
Topics: Administration, Oral; Adolescent; Adult; Affect; Anxiety; Arousal; Double-Blind Method; Female; Huma | 1995 |
The effects of administration of mCPP on psychological, cognitive, cardiovascular, hormonal and MHPG measurements in human volunteers.
Topics: Adrenocorticotropic Hormone; Adult; Affect; Anxiety; Arousal; Blood Pressure; Cognition; Cross-Over | 1994 |
Effects of alprazolam on increases in hormonal and anxiety levels induced by meta-chlorophenylpiperazine.
Topics: Adult; Alprazolam; Anxiety; Arousal; Growth Hormone; Humans; Hydrocortisone; Male; Panic; Piperazine | 1994 |
Specificity of ethanollike effects elicited by serotonergic and noradrenergic mechanisms.
Topics: Adult; Affect; Alcohol Drinking; Alcoholism; Anxiety; Blood Pressure; Cocaine; Ethanol; Hospitalizat | 1994 |
The 5-HT3 antagonist, BRL 46470 does not attenuate m-chlorophenylpiperazine (mCPP)-induced changes in human volunteers.
Topics: Administration, Oral; Adolescent; Adult; Anti-Anxiety Agents; Anxiety; Brain; Bridged Bicyclo Compou | 1994 |
Daily administration of m-chlorophenylpiperazine to healthy human volunteers rapidly attenuates many of its behavioral, hormonal, cardiovascular and temperature effects.
Topics: Adrenocorticotropic Hormone; Adult; Anxiety; Behavior; Blood Pressure; Body Temperature; Cardiovascu | 1996 |
Behavioral, physiological and neuroendocrine responses in healthy volunteers to m-chlorophenylpiperazine (m-CPP) with and without ondansetron pretreatment.
Topics: Adult; Anxiety; Behavior; Blood Pressure; Body Temperature; Euphoria; Female; Heart Rate; Humans; In | 1997 |
Serotonergic function in social phobia: comparison to normal control and obsessive-compulsive disorder subjects.
Topics: Adult; Analysis of Variance; Anxiety; Case-Control Studies; Female; Humans; Hydrocortisone; Male; Ne | 1998 |
5-HT1A receptor hypersensitivity in migraine is suggested by the m-chlorophenylpiperazine test.
Topics: Adult; Anxiety; Female; Humans; Hydrocortisone; Male; Migraine Disorders; Piperazines; Prolactin; Re | 1998 |
Decreased neuroendocrine responses to meta-chlorophenylpiperazine (m-CPP) but normal responses to ipsapirone in marathon runners.
Topics: Adult; Anxiety; Behavior; Body Temperature; Double-Blind Method; Exercise Test; Female; Hormones; Hu | 1999 |
Altered neuroendocrine and behavioral responses to m-chlorophenylpiperazine in 3,4-methylenedioxymethamphetamine (MDMA) users.
Topics: Adult; Affect; Anxiety; Behavior; Female; Hallucinogens; Humans; Hydrocortisone; Male; N-Methyl-3,4- | 1999 |
Low versus standard dose mCPP challenge in obsessive-compulsive patients.
Topics: Adult; Affect; Anxiety; Behavior; Cross-Over Studies; Disease Progression; Dose-Response Relationshi | 2001 |
Effects of ritanserin on the behavioral, neuroendocrine, and cardiovascular responses to meta-chlorophenylpiperazine in healthy human subjects.
Topics: Adult; Anxiety; Data Interpretation, Statistical; Double-Blind Method; Growth Hormone; Humans; Hydro | 1991 |
Comparative anxiogenic, neuroendocrine, and other physiologic effects of m-chlorophenylpiperazine given intravenously or orally to healthy volunteers.
Topics: Administration, Oral; Adult; Affect; Anxiety; Behavior; Body Temperature; Double-Blind Method; Emoti | 1989 |
Neuroendocrine evidence for serotonin receptor hypersensitivity in panic disorder.
Topics: Adult; Anxiety; Emotions; Fear; Female; Humans; Hydrocortisone; Male; Neurotransmitter Agents; Panic | 1988 |
48 other studies available for 1-(3-chlorophenyl)piperazine and Anxiety
| Article | Year |
|---|---|
The interplay between 5-HT
Topics: Animals; Anxiety; Behavior, Animal; Biguanides; Male; Mice; Ondansetron; Periaqueductal Gray; Pipera | 2022 |
Cananga odorata essential oil reverses the anxiety induced by 1-(3-chlorophenyl) piperazine through regulating the MAPK pathway and serotonin system in mice.
Topics: Administration, Inhalation; Animals; Anti-Anxiety Agents; Anxiety; Cananga; Dose-Response Relationsh | 2018 |
Role of 5-HT2C receptors of the dorsal hippocampus in the modulation of anxiety- and panic-related defensive responses in rats.
Topics: Aminopyridines; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Ethylamines; Hippocampus; | 2019 |
[Involvement of some subtypes of 5-HT2-receptors in affective behavior in female rats].
Topics: Animals; Animals, Outbred Strains; Anti-Anxiety Agents; Anxiety; Depression; Estrogens; Estrus; Fema | 2012 |
Lower anxiogenic effects of serotonin agonists are associated with lower activation of amygdala and lateral orbital cortex in adolescent male rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Age Factors; Amygdala; Animals; Anxiety; Behavior, Animal; D | 2013 |
Anxiety-like effects of meta-chlorophenylpiperazine in paradoxically sleep-deprived mice.
Topics: Animals; Anxiety; Behavior, Animal; Designer Drugs; Dose-Response Relationship, Drug; Male; Mice; Pi | 2014 |
Prototypical anxiolytics do not reduce anxiety-like behavior in the open field in C57BL/6J mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Disease Models, Animal; Humans; Mice; Mice, | 2015 |
Attention bias to threat indicates anxiety differences in sheep.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Attentional Bias; Diazepam; Dogs; Fear; Feeding Behavior; Fem | 2016 |
Acute engagement of G
Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain Mapping; Cannabinoid Receptor Antagonists; Clozapine; D | 2018 |
Behavioral effects of 1-(m-chlorophenyl)piperazine (m-CPP) in a rat model of tardive dyskinesia.
Topics: Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Dopamine Antagonists; Dyskinesia, Drug-I | 2008 |
Exercise is associated with reduction in the anxiogenic effect of mCPP on acoustic startle.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Disease Models, Anim | 2008 |
Trazodone generates m-CPP: in 2008 risks from m-CPP might outweigh benefits of trazodone.
Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Biotransformation; Brain; Dose-Response | 2009 |
Acute SSRI-induced anxiogenic and brain metabolic effects are attenuated 6 months after initial MDMA-induced depletion.
Topics: Animals; Anxiety; Axons; Brain; Citalopram; Fluoxetine; Male; N-Methyl-3,4-methylenedioxyamphetamine | 2010 |
Fear-potentiated startle, but not light-enhanced startle, is enhanced by anxiogenic drugs.
Topics: Animals; Anxiety; Fear; Light; Male; Pentylenetetrazole; Photic Stimulation; Piperazines; Rats; Rats | 2010 |
[Behavioral effects of m-CPP and ketanserine during ovarian cycle in female rats].
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Brain; Depression; E | 2010 |
Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice.
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Ethylamines; Indoles; Interpersonal Relations; Male; M | 2011 |
[Effects of 5-HT1 and 5-HT2 serotonin receptors on anxiety- and depression-like behavior in female rats].
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; D | 2011 |
[Behavioral effects of ketanserine in prenatally stressed female rats].
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Depression; Female; | 2012 |
Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs.
Topics: Adrenergic alpha-Antagonists; Amygdala; Animals; Anxiety; Caffeine; Carbolines; Central Nervous Syst | 2003 |
Experimental anxiety and antiepileptics: the effects of valproate and vigabatrin in the mirrored chamber test.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Conflict, Psychological; Disease Models, Ani | 2003 |
A PET study after treatment with an anxiety-provoking agent, m-chlorophenyl-piperazine, in conscious rhesus monkeys.
Topics: Animals; Anxiety; Brain; Cerebrovascular Circulation; Consciousness; Dose-Response Relationship, Dru | 2003 |
Anxiety-like state associates with taste to produce conditioned taste aversion.
Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Central Nervous System Depressants; Conditio | 2004 |
The use of sudden darkness in mice: a behavioural and pharmacological approach.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Behavior, Animal; Darkness; Female; Male; | 2005 |
Brain angiotensin and anxiety-related behavior: the transgenic rat TGR(ASrAOGEN)680.
Topics: Analysis of Variance; Angiotensins; Animals; Animals, Genetically Modified; Anxiety; Behavior, Anima | 2005 |
m-Chlorophenylpiperazine exacerbates perception of salicylate-induced tinnitus in rats.
Topics: Animals; Anxiety; Avoidance Learning; Female; Injections, Intraperitoneal; Piperazines; Rats; Rats, | 2005 |
Effects of soybean food pellets on m-CPP-induced anxiety model of mice.
Topics: Animal Feed; Animals; Anxiety; Disease Models, Animal; Glycine max; Male; Maze Learning; Mice; Mice, | 2006 |
Influence of diltiazem on the behavior of zolpidem-treated mice in the elevated-plus maze test.
Topics: 5-Hydroxytryptophan; Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Calcium Channel Blocker | 2007 |
5-Hydroxytryptamine2C receptor contribution to m-chlorophenylpiperazine and N-methyl-beta-carboline-3-carboxamide-induced anxiety-like behavior and limbic brain activation.
Topics: Aminopyridines; Animals; Anxiety; Behavior, Animal; Carbolines; Indoles; Limbic System; Magnetic Res | 2007 |
Anxiogenic-like effects of mCPP microinfusions into the amygdala (but not dorsal or ventral hippocampus) in mice exposed to elevated plus-maze.
Topics: Amygdala; Analysis of Variance; Animals; Anxiety; Environment; Exploratory Behavior; Hippocampus; Ma | 2007 |
5-HT2 receptor activation in the midbrain periaqueductal grey (PAG) reduces anxiety-like behaviour in mice.
Topics: Animals; Anxiety; Behavior, Animal; Dose-Response Relationship, Drug; Ketanserin; Male; Mesencephalo | 2008 |
Response to meta-chlorophenylpiperazine in panic disorder patients and healthy subjects: influence of reduction in intravenous dosage.
Topics: Adult; Anxiety; Dose-Response Relationship, Drug; Female; Heart Rate; Humans; Injections, Intravenou | 1994 |
Effects of housing, restraint and chronic treatments with mCPP and sertraline on behavioural responses to mCPP.
Topics: 1-Naphthylamine; Animals; Anxiety; Behavior, Animal; Eating; Housing, Animal; Interpersonal Relation | 1993 |
Behavioural and pharmacological characterisation of the elevated "zero-maze" as an animal model of anxiety.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Chl | 1994 |
Behavioral and neuroendocrine responses to m-chlorophenylpiperazine in subtypes of alcoholics and in healthy comparison subjects.
Topics: Adrenocorticotropic Hormone; Adult; Age of Onset; Alcohol Drinking; Alcoholism; Anger; Antisocial Pe | 1997 |
mCPP-induced anxiety--a potential new method for screening anxiolytic activity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; | 1996 |
The meta-chlorophenylpiperazine challenge test in cocaine addicts: hormonal and psychological responses.
Topics: Adult; Anxiety; Cocaine; Humans; Hydrocortisone; Male; Piperazines; Prolactin; Serotonin Receptor Ag | 1997 |
Some doubts about the basic concept of hole-board test.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Central Nervous System Stimulants; Chlordia | 1996 |
mCPP-induced anxiety in the light-dark box in rats--a new method for screening anxiolytic activity.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Darkness; Dose-Response Relationship, Drug; Drug Evaluation, | 1998 |
Effect of reserpine on behavioural responses to agonists at 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor subtypes.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Anxiety; Behavior, Animal; Body Tempe | 1999 |
Discriminative stimulus properties of mCPP and alprazolam are not mediated by anxiety.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Cues; Discrimination Learning; Discrim | 1999 |
Sex differences in the discriminative stimulus effects of m-chlorophenylpiperazine and ethanol withdrawal.
Topics: Analysis of Variance; Animals; Anxiety; Central Nervous System Depressants; Discrimination Learning; | 2000 |
Anxiety-like effects induced by acute fluoxetine, sertraline or m-CPP treatment are reversed by pretreatment with the 5-HT2C receptor antagonist SB-242084 but not the 5-HT1A receptor antagonist WAY-100635.
Topics: Aminopyridines; Animals; Antidepressive Agents, Second-Generation; Anxiety; Behavior, Animal; Fluoxe | 2001 |
Ethopharmacological analysis of the unstable elevated exposed plus maze, a novel model of extreme anxiety: predictive validity and sensitivity to anxiogenic agents.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Caffeine; Ca | 2002 |
m-Chlorophenylpiperazine enhances neophobic and anxious behaviour in mice.
Topics: Analysis of Variance; Animals; Anxiety; Choice Behavior; Exploratory Behavior; Male; Mice; Mice, Inb | 1991 |
Anxiogenic-like effect of infusing 1-(3-chlorophenyl) piperazine (mCPP) into the hippocampus.
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Dose-Response Relationship, Drug; Hippocampus; Injecti | 1990 |
Anxiogenic-like effects of mCPP and TFMPP in animal models are opposed by 5-HT1C receptor antagonists.
Topics: Animals; Anxiety; Drug Interactions; Feeding Behavior; Indoles; Interpersonal Relations; Male; Motor | 1989 |
Serotonin function in anxiety. II. Effects of the serotonin agonist MCPP in panic disorder patients and healthy subjects.
Topics: Adult; Anxiety; Emotions; Fear; Female; Growth Hormone; Hemodynamics; Humans; Hydrocortisone; Male; | 1987 |
Trazodone and m-chlorophenylpiperazine. Concentration in brain and receptor activity in regions in the brain associated with anxiety.
Topics: Animals; Anxiety; Brain; Clonidine; Flunitrazepam; In Vitro Techniques; Isomerism; Male; Membranes; | 1985 |