1-(3-chlorophenyl)piperazine has been researched along with Anorexia in 7 studies
1-(3-chlorophenyl)piperazine: supposed metabolite of TRAZODONE; RN given refers to parent cpd; structure
1-(3-chlorophenyl)piperazine : A N-arylpiperazine that is piperazine carrying a 3-chlorophenyl substituent at position 1. It is a metabolite of the antidepressant drug trazodone.
Anorexia: The lack or loss of APPETITE accompanied by an aversion to food and the inability to eat. It is the defining characteristic of the disorder ANOREXIA NERVOSA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We previously reported that lesions of the medial parabrachial nucleus (PBN) enhanced d-fenfluramine (DFEN)-induced anorexia; a finding that suggests these lesions may potentiate the release of serotonin (5HT) or increase the postsynaptic action of 5HT." | 7.73 | Medial parabrachial nucleus neurons modulate d-fenfluramine-induced anorexia through 5HT2C receptors. ( Reilly, S; Trifunovic, R, 2006) |
| "We previously reported that lesions of the medial parabrachial nucleus (PBN) enhanced d-fenfluramine (DFEN)-induced anorexia; a finding that suggests these lesions may potentiate the release of serotonin (5HT) or increase the postsynaptic action of 5HT." | 3.73 | Medial parabrachial nucleus neurons modulate d-fenfluramine-induced anorexia through 5HT2C receptors. ( Reilly, S; Trifunovic, R, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rivera, HM | 1 |
| Santollo, J | 1 |
| Nikonova, LV | 1 |
| Eckel, LA | 1 |
| Rowland, NE | 1 |
| Robertson, K | 1 |
| Green, DJ | 1 |
| Trifunovic, R | 1 |
| Reilly, S | 1 |
| Takeda, H | 1 |
| Sadakane, C | 1 |
| Hattori, T | 1 |
| Katsurada, T | 1 |
| Ohkawara, T | 1 |
| Nagai, K | 1 |
| Asaka, M | 1 |
| Nonogaki, K | 1 |
| Ohba, Y | 1 |
| Sumii, M | 1 |
| Oka, Y | 1 |
| Samanin, R | 2 |
| Caccia, S | 1 |
| Bendotti, C | 1 |
| Borsini, F | 1 |
| Borroni, E | 1 |
| Invernizzi, R | 1 |
| Pataccini, R | 1 |
| Mennini, T | 2 |
| Garattini, S | 1 |
7 other studies available for 1-(3-chlorophenyl)piperazine and Anorexia
| Article | Year |
|---|---|
Estradiol increases the anorexia associated with increased 5-HT(2C) receptor activation in ovariectomized rats.
Topics: Analysis of Variance; Animals; Anorexia; Brain; Disease Models, Animal; Drug Administration Routes; | 2012 |
Effect of repeated administration of dexfenfluramine on feeding and brain Fos in mice.
Topics: Animals; Anorexia; Brain; Dexfenfluramine; Dose-Response Relationship, Drug; Drug Administration Sch | 2003 |
Medial parabrachial nucleus neurons modulate d-fenfluramine-induced anorexia through 5HT2C receptors.
Topics: Anorexia; Appetite; Energy Intake; Fenfluramine; Ibotenic Acid; Neurons; Piperazines; Pons; Receptor | 2006 |
Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism.
Topics: Acylation; Aminopyridines; Animals; Anorexia; Antineoplastic Agents; Body Weight; Chalcones; Cisplat | 2008 |
Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independent pathway in mice.
Topics: Animals; Anorexia; Calcium-Binding Proteins; DNA-Binding Proteins; Eating; Hypothalamus; Leptin; Mal | 2008 |
Further studies on the mechanism of serotonin-dependent anorexia in rats.
Topics: Animals; Anorexia; Brain; Feeding and Eating Disorders; Feeding Behavior; Female; Fenfluramine; Huma | 1980 |
Evidence that it is possible to cause anorexia by increasing release and/or directly stimulating postsynaptic serotonin receptors in the brain.
Topics: Animals; Anorexia; Appetite Depressants; Brain; Feeding Behavior; Fenfluramine; Piperazines; Piperid | 1980 |