1-(3-chlorophenyl)piperazine has been researched along with Alzheimer Disease in 4 studies
1-(3-chlorophenyl)piperazine: supposed metabolite of TRAZODONE; RN given refers to parent cpd; structure
1-(3-chlorophenyl)piperazine : A N-arylpiperazine that is piperazine carrying a 3-chlorophenyl substituent at position 1. It is a metabolite of the antidepressant drug trazodone.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lawlor, BA | 4 |
| Sunderland, T | 4 |
| Mellow, AM | 4 |
| Molchan, SE | 2 |
| Martinez, R | 1 |
| Murphy, DL | 4 |
| Hill, JL | 3 |
| Newhouse, PA | 1 |
3 trials available for 1-(3-chlorophenyl)piperazine and Alzheimer Disease
| Article | Year |
|---|---|
A pilot placebo-controlled study of chronic m-CPP administration in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Double-Blind Method; Female; Humans; Male; Middle Aged; Neuropsychological | 1991 |
Hyperresponsivity to the serotonin agonist m-chlorophenylpiperazine in Alzheimer's disease. A controlled study.
Topics: Aged; Alzheimer Disease; Blood Pressure; Brain; Female; Humans; Hydrocortisone; Male; Personality In | 1989 |
A pilot study of serotonergic system responsivity in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Clinical Trials as Topic; Double-Blind Method; Humans; Pilot Projects; Pipe | 1988 |
1 other study available for 1-(3-chlorophenyl)piperazine and Alzheimer Disease
| Article | Year |
|---|---|
A preliminary study of the effects of intravenous m-chlorophenylpiperazine, a serotonin agonist, in elderly subjects.
Topics: Aged; Alzheimer Disease; Attention; Female; Humans; Hydrocortisone; Infusions, Intravenous; Male; Me | 1989 |