1-(3-chlorophenyl)biguanide has been researched along with Seizures in 5 studies
1-(3-chlorophenyl)biguanide: RN given refers to parent cp; a 5-HT3 receptor agonist
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Stroke was rendered in rats by introduction of an autologous clot into the middle cerebral artery (MCA)." | 5.37 | Tropisetron ameliorates ischemic brain injury in an embolic model of stroke. ( Barzegar-Fallah, A; Daneshmand, A; Dehpour, AR; Fakhfouri, G; Mehr, SE; Mohammadi-Rick, S; Rahimian, R; Shabanzadeh, AP, 2011) |
| "In this regard, we used a model of clonic seizures induced by pentylenetetrazole (PTZ) in male NMRI mice to investigate whether morphine and citalopram exhibit additive anticonvulsant effects and, if so, whether this effect is mediated through modulation of 5-HT(3) receptors." | 5.37 | The role of 5-HT(3) receptors in the additive anticonvulsant effects of citalopram and morphine on pentylenetetrazole-induced clonic seizures in mice. ( Bahremand, A; Dehpour, AR; Ebrahimi, A; Fakhfouri, G; Ghasemi, A; Ghasemi, M; Loloee, S; Payandemehr, B; Pourmand, N; Rahimian, R; Ziai, P, 2011) |
| " In the present study, we investigated the effect of genistein on pentylenetetrazole-induced seizures in ovariectomized mice and the possible involvement of estrogenic and serotonergic pathways in the probable effects of genistein." | 3.85 | Genistein modulation of seizure: involvement of estrogen and serotonin receptors. ( Algazo, M; Alshaib, H; Amiri Gheshlaghi, S; Dehpour, AR; Mohammad Jafari, R; Rahimi, N, 2017) |
| "Citalopram is a selective serotonin reuptake inhibitor (SSRI), widely used in the treatment of depressive disorders." | 1.38 | 5-HT(3) receptor mediates the dose-dependent effects of citalopram on pentylenetetrazole-induced clonic seizure in mice: involvement of nitric oxide. ( Amouzegar, A; Bahremand, A; Dehpour, AR; Payandemehr, B; Rahimian, R; Sharifzadeh, M; Ziai, P, 2012) |
| "Stroke was rendered in rats by introduction of an autologous clot into the middle cerebral artery (MCA)." | 1.37 | Tropisetron ameliorates ischemic brain injury in an embolic model of stroke. ( Barzegar-Fallah, A; Daneshmand, A; Dehpour, AR; Fakhfouri, G; Mehr, SE; Mohammadi-Rick, S; Rahimian, R; Shabanzadeh, AP, 2011) |
| "In this regard, we used a model of clonic seizures induced by pentylenetetrazole (PTZ) in male NMRI mice to investigate whether morphine and citalopram exhibit additive anticonvulsant effects and, if so, whether this effect is mediated through modulation of 5-HT(3) receptors." | 1.37 | The role of 5-HT(3) receptors in the additive anticonvulsant effects of citalopram and morphine on pentylenetetrazole-induced clonic seizures in mice. ( Bahremand, A; Dehpour, AR; Ebrahimi, A; Fakhfouri, G; Ghasemi, A; Ghasemi, M; Loloee, S; Payandemehr, B; Pourmand, N; Rahimian, R; Ziai, P, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amiri Gheshlaghi, S | 1 |
| Mohammad Jafari, R | 1 |
| Algazo, M | 1 |
| Rahimi, N | 1 |
| Alshaib, H | 1 |
| Dehpour, AR | 4 |
| Mishra, A | 1 |
| Goel, RK | 1 |
| Rahimian, R | 3 |
| Daneshmand, A | 1 |
| Mehr, SE | 1 |
| Barzegar-Fallah, A | 1 |
| Mohammadi-Rick, S | 1 |
| Fakhfouri, G | 2 |
| Shabanzadeh, AP | 1 |
| Bahremand, A | 2 |
| Payandemehr, B | 2 |
| Ziai, P | 2 |
| Pourmand, N | 1 |
| Loloee, S | 1 |
| Ebrahimi, A | 1 |
| Ghasemi, A | 1 |
| Ghasemi, M | 1 |
| Amouzegar, A | 1 |
| Sharifzadeh, M | 1 |
5 other studies available for 1-(3-chlorophenyl)biguanide and Seizures
| Article | Year |
|---|---|
Genistein modulation of seizure: involvement of estrogen and serotonin receptors.
Topics: Animals; Anticonvulsants; Biguanides; Dose-Response Relationship, Drug; Fabaceae; Female; Genistein; | 2017 |
Chronic 5-HT
Topics: Animals; Anticonvulsants; Biguanides; Cerebral Cortex; Dose-Response Relationship, Drug; Hippocampus | 2016 |
Tropisetron ameliorates ischemic brain injury in an embolic model of stroke.
Topics: Analysis of Variance; Animals; Biguanides; Blood Gas Analysis; Brain Edema; Brain Infarction; Brain | 2011 |
The role of 5-HT(3) receptors in the additive anticonvulsant effects of citalopram and morphine on pentylenetetrazole-induced clonic seizures in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Biguanides; Citalopram; Disease Models, Animal; Dose | 2011 |
5-HT(3) receptor mediates the dose-dependent effects of citalopram on pentylenetetrazole-induced clonic seizure in mice: involvement of nitric oxide.
Topics: Animals; Anticonvulsants; Biguanides; Citalopram; Dose-Response Relationship, Drug; Enzyme Inhibitor | 2012 |