1-(3-chlorophenyl)biguanide has been researched along with Neuroblastoma in 8 studies
1-(3-chlorophenyl)biguanide: RN given refers to parent cp; a 5-HT3 receptor agonist
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In both N1E-115 neuroblastoma cells and human embryonic kidney 293 cells stably expressing the 5-HT3 receptor As subunit, (+)-verapamil, (-)-verapamil, diltiazem, and nimodipine caused reversible and concentration-dependent (IC50 = 2." | 3.69 | Direct inhibition of 5-hydroxytryptamine3 receptors by antagonists of L-type Ca2+ channels. ( Gunthorpe, MJ; Hargreaves, AC; Lummis, SC; Taylor, CW, 1996) |
| " In the presence of 100 microM 2-Me5-HT, the upper part of the 5-HT dose-response curve was shifted to the right but reached the same maximum value as in the absence of 2-Me5-HT." | 1.28 | The agonist properties of m-chlorophenylbiguanide and 2-methyl-5-hydroxytryptamine on 5-HT3 receptors in N1E-115 neuroblastoma cells. ( Lummis, SC; Martin, IL; Sepúlveda, MI, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (75.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stewart, A | 1 |
| Davies, PA | 1 |
| Kirkness, EF | 1 |
| Safa, P | 1 |
| Hales, TG | 1 |
| Lummis, SC | 4 |
| Sepúlveda, MI | 3 |
| Kilpatrick, GJ | 1 |
| Baker, J | 1 |
| Hargreaves, AC | 1 |
| Gunthorpe, MJ | 1 |
| Taylor, CW | 1 |
| van Hooft, JA | 1 |
| Kreikamp, AP | 1 |
| Vijverberg, HP | 1 |
| Rondé, P | 2 |
| Nichols, RA | 2 |
| Boess, FG | 1 |
| Martin, IL | 2 |
8 other studies available for 1-(3-chlorophenyl)biguanide and Neuroblastoma
| Article | Year |
|---|---|
Introduction of the 5-HT3B subunit alters the functional properties of 5-HT3 receptors native to neuroblastoma cells.
Topics: Animals; Biguanides; Calcium; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Dru | 2003 |
Characterization of [3H]meta-chlorophenylbiguanide binding to 5-HT3 receptors in N1E-115 neuroblastoma cells.
Topics: Animals; Biguanides; Binding, Competitive; Electrophysiology; Mice; Neuroblastoma; Radioligand Assay | 1993 |
Direct inhibition of 5-hydroxytryptamine3 receptors by antagonists of L-type Ca2+ channels.
Topics: Biguanides; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Chann | 1996 |
Native serotonin 5-HT3 receptors expressed in Xenopus oocytes differ from homopentameric 5-HT3 receptors.
Topics: Animals; Biguanides; Cell Differentiation; Dopamine; Female; Kinetics; Macromolecular Substances; Me | 1997 |
High calcium permeability of serotonin 5-HT3 receptors on presynaptic nerve terminals from rat striatum.
Topics: Animals; Biguanides; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane Permeability | 1998 |
Postsynaptic target regulates functional responses induced by 5-HT3 serotonin receptors on axonal varicosities of NG108-15 hybrid neuroblastoma cells.
Topics: Animals; Axons; Biguanides; Calcium; Cell Differentiation; Coculture Techniques; Culture Media, Cond | 2001 |
5-HT3 receptors in NG108-15 neuroblastoma x glioma cells: effect of the novel agonist 1-(m-chlorophenyl)-biguanide.
Topics: Animals; Biguanides; Binding, Competitive; Evoked Potentials; Glioma; Hybrid Cells; Imidazoles; Indo | 1992 |
The agonist properties of m-chlorophenylbiguanide and 2-methyl-5-hydroxytryptamine on 5-HT3 receptors in N1E-115 neuroblastoma cells.
Topics: Animals; Biguanides; Membrane Potentials; Mice; Neuroblastoma; Neurons; Radioligand Assay; Receptors | 1991 |