1-(3-chlorophenyl)biguanide has been researched along with Multiple Sclerosis in 1 studies
1-(3-chlorophenyl)biguanide: RN given refers to parent cp; a 5-HT3 receptor agonist
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with tropisetron and granisetron markedly suppressed the clinical symptoms of EAE (p<0." | 5.39 | Tropisetron diminishes demyelination and disease severity in an animal model of multiple sclerosis. ( Aminian, A; Dehpour, AR; Ghazi-Khansari, M; Hassanzadeh, G; Javadi, S; Kafami, L; Mehr, SE; Noorbakhsh, F; Rahimian, R, 2013) |
| "Treatment with tropisetron and granisetron markedly suppressed the clinical symptoms of EAE (p<0." | 1.39 | Tropisetron diminishes demyelination and disease severity in an animal model of multiple sclerosis. ( Aminian, A; Dehpour, AR; Ghazi-Khansari, M; Hassanzadeh, G; Javadi, S; Kafami, L; Mehr, SE; Noorbakhsh, F; Rahimian, R, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aminian, A | 1 |
| Noorbakhsh, F | 1 |
| Ghazi-Khansari, M | 1 |
| Kafami, L | 1 |
| Javadi, S | 1 |
| Hassanzadeh, G | 1 |
| Rahimian, R | 1 |
| Dehpour, AR | 1 |
| Mehr, SE | 1 |
1 other study available for 1-(3-chlorophenyl)biguanide and Multiple Sclerosis
| Article | Year |
|---|---|
Tropisetron diminishes demyelination and disease severity in an animal model of multiple sclerosis.
Topics: Animals; Biguanides; Cell Proliferation; Demyelinating Diseases; Disease Models, Animal; Dose-Respon | 2013 |