Compounds > 1-(3-4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine-dihydrochloride

1-(3-4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine-dihydrochloride and Dystonia

1-(3-4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine-dihydrochloride has been researched along with Dystonia* in 1 studies

Other Studies

1 other study(ies) available for 1-(3-4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine-dihydrochloride and Dystonia

Article	Year
Possible involvement of a sigma receptor subtype in the neck dystonia in rats. Pharmacology, biochemistry, and behavior, 1999, Volume: 62, Issue:1 To clarify which subtype of sigma receptors is involved in the sigma receptor-mediated neck dystonia in rats, we examined whether 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride (SA4503), a selective sigma1 receptor agonist, and 1,3-di-(2-tolyl)guanidine (DTG), a sigma1 and sigma2 receptor agonist, induce neck dystonia in rats. Microinjection of SA4503 into the red nucleus of rat brain scarcely produced neck dystonia at the concentration of 10 nmol/0.5 microl. On the contrary, DTG produced significant dystonia at a concentrations of more than 5 nmol/0.5 microl. These results indicate that the sigma2 receptor subtype, but not sigma1 receptor subtype, may play an important role in the sigma receptor-mediated neck dystonia in rats. Topics: Animals; Dystonia; Guanidines; Male; Microinjections; Neck; Piperazines; Rats; Rats, Wistar; Receptors, sigma; Red Nucleus; Sigma-1 Receptor; Time Factors	1999

Article

Year

Possible involvement of a sigma receptor subtype in the neck dystonia in rats.

Pharmacology, biochemistry, and behavior, 1999, Volume: 62, Issue:1

To clarify which subtype of sigma receptors is involved in the sigma receptor-mediated neck dystonia in rats, we examined whether 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride (SA4503), a selective sigma1 receptor agonist, and 1,3-di-(2-tolyl)guanidine (DTG), a sigma1 and sigma2 receptor agonist, induce neck dystonia in rats. Microinjection of SA4503 into the red nucleus of rat brain scarcely produced neck dystonia at the concentration of 10 nmol/0.5 microl. On the contrary, DTG produced significant dystonia at a concentrations of more than 5 nmol/0.5 microl. These results indicate that the sigma2 receptor subtype, but not sigma1 receptor subtype, may play an important role in the sigma receptor-mediated neck dystonia in rats.

Topics: Animals; Dystonia; Guanidines; Male; Microinjections; Neck; Piperazines; Rats; Rats, Wistar; Receptors, sigma; Red Nucleus; Sigma-1 Receptor; Time Factors

1999