1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol has been researched along with Experimental Neoplasms in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (64.71) | 18.7374 |
| 1990's | 6 (35.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adams, GE; Cole, S; Fielden, EM; Jenkins, TC; Naylor, MA; O'Neill, P; Stier, MA; Stratford, IJ; Suto, MJ; Threadgill, MD | 1 |
| Adams, GE; Ahmed, I; Sheldon, PW; Stratford, IJ | 2 |
| Walton, MI; Workman, P | 1 |
| Bremner, JC | 1 |
| Adams, GE; Bremner, JC; Stratford, IJ; Wood, PJ | 1 |
| Adams, GE; Bremner, JC; Cole, S; Edwards, HS; Stratford, IJ | 1 |
| Chaplin, DJ; Horsman, MR | 1 |
| Koch, CJ; Wallen, CA; Wheeler, KT; Wong, KH | 1 |
| Adams, GE; Godden, J; Howells, N; Stratford, IJ | 1 |
| Chaplin, DJ | 1 |
| Chapman, JD; Kanclerz, A | 1 |
| Brown, JM | 1 |
| Chaplin, DJ; Durand, RE; Olive, PL | 1 |
| Gulyas, S; Hill, RP; Whitmore, GF | 1 |
| Adams, GE; Ahmed, I; Fielden, EM; Jenkins, TC; Sheldon, PW; Stratford, IJ; Walling, JM | 1 |
| Chaplin, DJ; Durand, RE; Jenkins, TC; Stratford, IJ | 1 |
2 review(s) available for 1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol and Experimental Neoplasms
| Article | Year |
|---|---|
Assessing the bioreductive effectiveness of the nitroimidazole RSU1069 and its prodrug RB6145: with particular reference to in vivo methods of evaluation.
Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Cell Line; Cell Survival; Humans; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxidation-Reduction; Prodrugs; Radiation-Sensitizing Agents | 1993 |
Sensitizers and protectors in radiotherapy.
Topics: Amifostine; Animals; Aziridines; Clinical Trials as Topic; Drug Evaluation; Etanidazole; Glutathione; Humans; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy | 1985 |
1 trial(s) available for 1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol and Experimental Neoplasms
| Article | Year |
|---|---|
Sensitizers and protectors in radiotherapy.
Topics: Amifostine; Animals; Aziridines; Clinical Trials as Topic; Drug Evaluation; Etanidazole; Glutathione; Humans; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy | 1985 |
15 other study(ies) available for 1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol and Experimental Neoplasms
| Article | Year |
|---|---|
Synthesis and evaluation of alpha-[[(2-haloethyl)amino]methyl]-2- nitro-1H-imidazole-1-ethanols as prodrugs of alpha-[(1-aziridinyl)methyl]-2- nitro-1H-imidazole-1-ethanol (RSU-1069) and its analogues which are radiosensitizers and bioreductively activate
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Cytotoxins; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Prodrugs; Radiation-Sensitizing Agents | 1990 |
Radiation sensitization and chemopotentiation: RSU 1069, a compound more efficient than misonidazole in vitro and in vivo.
Topics: Animals; Aziridines; Azirines; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Radiation; Drug Synergism; Female; Melphalan; Mice; Mice, Inbred Strains; Misonidazole; Neoplasms, Experimental; Oxygen; Radiation-Sensitizing Agents | 1984 |
Pharmacology of the mixed-function radio- and chemosensitizers CB 1954 and RSU 1069.
Topics: Animals; Aziridines; Azirines; Brain; Drug Synergism; Female; Male; Metabolic Clearance Rate; Mice; Mice, Inbred Strains; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Radiation-Sensitizing Agents; Time Factors | 1984 |
RSU 1069, a 2-nitroimidazole containing an alkylating group: high efficiency as a radio- and chemosensitizer in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Aziridines; Azirines; Cell Line; Cell Survival; Combined Modality Therapy; Cricetinae; Cricetulus; Drug Synergism; Mice; Mice, Inbred C57BL; Misonidazole; Neoplasms, Experimental; Radiation-Sensitizing Agents | 1984 |
Can 31P magnetic resonance spectroscopy measurements of changes in experimental tumour metabolism be related to modification of oxygenation status?
Topics: Animals; Cell Hypoxia; Magnetic Resonance Spectroscopy; Mice; Misonidazole; Neoplasms, Experimental; Phosphorus; Radiation-Sensitizing Agents; Time Factors | 1992 |
Bioreductive drugs as post-irradiation sensitizers: comparison of dual function agents with SR 4233 and the mitomycin C analogue EO9.
Topics: Animals; Antineoplastic Agents; Aziridines; Cell Hypoxia; Cell Survival; Combined Modality Therapy; Dose-Response Relationship, Drug; Indolequinones; Indoles; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Prodrugs; Tirapazamine; Triazines | 1992 |
Tumor blood flow changes induced by chemical modifiers of radiation response.
Topics: Animals; Antineoplastic Agents; Blood Flow Velocity; Cisplatin; Doxorubicin; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1992 |
Pharmacokinetics and cytotoxicity of RSU-1069 in subcutaneous 9L tumours under oxic and hypoxic conditions.
Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Injections, Subcutaneous; Male; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Oxygen; Rats; Rats, Inbred F344; Tumor Stem Cell Assay | 1991 |
Induction of tumour hypoxia post-irradiation: a method for increasing the sensitizing efficiency of misonidazole and RSU 1069 in vivo.
Topics: Animals; Combined Modality Therapy; Female; Hydralazine; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Oxygen; Radiation-Sensitizing Agents | 1989 |
Hydralazine-induced tumor hypoxia: a potential target for cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Aziridines; Drug Synergism; Female; Hydralazine; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Misonidazole; Mitomycins; Neoplasms, Experimental; Regional Blood Flow | 1989 |
Influence of misonidazole, SR-2508, RSU-1069 and WR-2721 on spontaneous metastases in C57BL mice.
Topics: Amifostine; Animals; Etanidazole; Lung Neoplasms; Male; Melanoma; Mice; Mice, Inbred C57BL; Misonidazole; Neoplasm Metastasis; Neoplasms, Experimental; Nitroimidazoles; Radiation-Protective Agents; Radiation-Sensitizing Agents | 1988 |
Cytotoxicity of RSU 1069 in spheroids and murine tumors.
Topics: Animals; Cell Survival; Cricetinae; In Vitro Techniques; Mice; Misonidazole; Models, Biological; Neoplasms, Experimental; Oxygen; Radiation-Sensitizing Agents | 1987 |
Studies of the in vivo and in vitro cytotoxicity of the drug RSU-1069.
Topics: Animals; Cell Line; Cell Survival; Dose-Response Relationship, Drug; HeLa Cells; Male; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Oxygen; Radiation Tolerance | 1986 |
Analogues of RSU-1069: radiosensitization and toxicity in vitro and in vivo.
Topics: Animals; Cell Line; Cell Survival; Combined Modality Therapy; Cricetinae; In Vitro Techniques; Mice; Mice, Inbred C57BL; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Radiation-Sensitizing Agents | 1986 |
The radiosensitizing and toxic effects of RSU-1069 on hypoxic cells in a murine tumor.
Topics: Animals; Cell Survival; Combined Modality Therapy; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Oxygen; Radiation-Sensitizing Agents | 1986 |