Compounds > 1-(1-naphthylmethyl)piperazine

1-(1-naphthylmethyl)piperazine and Mastitis--Bovine

1-(1-naphthylmethyl)piperazine has been researched along with Mastitis--Bovine* in 1 studies

Other Studies

1 other study(ies) available for 1-(1-naphthylmethyl)piperazine and Mastitis--Bovine

Article	Year
Effect of the inhibitors phenylalanine arginyl ß-naphthylamide (PAßN) and 1-(1-naphthylmethyl)-piperazine (NMP) on expression of genes in multidrug efflux systems of Escherichia coli isolates from bovine mastitis. Research in veterinary science, 2014, Volume: 97, Issue:2 The multidrug efflux system in bacteria can reduce antibiotic concentration inside the cell, leading to failure in the treatment of bacterial diseases. This study evaluated the influence of two efflux pump inhibitors (EPIs), phenylalanine arginyl ß-naphthylamide (PAßN) and 1-(1-naphthylmethyl)-piperazine (NMP), on the gene expression of three multidrug efflux systems, AcrAB, AcrEF and EmrAB in Escherichia coli bovine mastitis isolates resistant to ampicillin and sulfamethoxazole/trimethoprim simultaneously. Each isolate had at least three multidrug efflux system genes. The acrA and acrB had the lowest expression levels in all treatments, while the emrA or emrB showed the highest expression levels in the presence of ampicillin, sulfamethoxazole/trimethoprim, PAβN and NMP. EPIs also contributed to the decrease in arcF expression when used in combination with ampicillin treatment. Since PAßN showed stronger effects than NMP, it may serve as an alternative to assist in the antimicrobial therapy of mastitis. Topics: Ampicillin; Animals; Anti-Infective Agents; Bacterial Proteins; Cattle; Colony Count, Microbial; Dipeptides; Drug Resistance, Multiple, Bacterial; Escherichia coli; Female; Gene Expression Regulation, Bacterial; Mastitis, Bovine; Membrane Transport Proteins; Microbial Sensitivity Tests; Piperazines; Polymerase Chain Reaction; Trimethoprim, Sulfamethoxazole Drug Combination	2014

Article

Year

Effect of the inhibitors phenylalanine arginyl ß-naphthylamide (PAßN) and 1-(1-naphthylmethyl)-piperazine (NMP) on expression of genes in multidrug efflux systems of Escherichia coli isolates from bovine mastitis.

Research in veterinary science, 2014, Volume: 97, Issue:2

The multidrug efflux system in bacteria can reduce antibiotic concentration inside the cell, leading to failure in the treatment of bacterial diseases. This study evaluated the influence of two efflux pump inhibitors (EPIs), phenylalanine arginyl ß-naphthylamide (PAßN) and 1-(1-naphthylmethyl)-piperazine (NMP), on the gene expression of three multidrug efflux systems, AcrAB, AcrEF and EmrAB in Escherichia coli bovine mastitis isolates resistant to ampicillin and sulfamethoxazole/trimethoprim simultaneously. Each isolate had at least three multidrug efflux system genes. The acrA and acrB had the lowest expression levels in all treatments, while the emrA or emrB showed the highest expression levels in the presence of ampicillin, sulfamethoxazole/trimethoprim, PAβN and NMP. EPIs also contributed to the decrease in arcF expression when used in combination with ampicillin treatment. Since PAßN showed stronger effects than NMP, it may serve as an alternative to assist in the antimicrobial therapy of mastitis.

Topics: Ampicillin; Animals; Anti-Infective Agents; Bacterial Proteins; Cattle; Colony Count, Microbial; Dipeptides; Drug Resistance, Multiple, Bacterial; Escherichia coli; Female; Gene Expression Regulation, Bacterial; Mastitis, Bovine; Membrane Transport Proteins; Microbial Sensitivity Tests; Piperazines; Polymerase Chain Reaction; Trimethoprim, Sulfamethoxazole Drug Combination

2014