Compounds > 1-(1-glycero)dodeca-1-3-5-7-9-pentaene

1-(1-glycero)dodeca-1-3-5-7-9-pentaene and Papilloma

1-(1-glycero)dodeca-1-3-5-7-9-pentaene has been researched along with Papilloma* in 1 studies

Other Studies

1 other study(ies) available for 1-(1-glycero)dodeca-1-3-5-7-9-pentaene and Papilloma

Article	Year
Carcinogenicity study of fecapentaene-12 diacetate on skin painting in SENCAR mice. Cancer letters, 1991, Volume: 56, Issue:1 To investigate the effects of both diol esterification and coadministration with antioxidant on the tumorigenicity of fecapentaene-12 (FP-12) preparations, diacetylfecapentaene-12 (DAFP-12) in dimethylsulfoxide (DMSO) was applied to SENCAR mouse skin with or without the stabilizer, vitamin E, twice/week for 5 weeks, following which all animals were promoted for up to 25 weeks by weekly applications of 12-O-tetradecanoylphorbol-13-acetate (TPA). While positive controls receiving 7,12-dimethylbenz[a]anthracene (DMBA) instead of DAFP-12 in a similar protocol all developed papillomas (average of 23/animal), papilloma incidence in mice given DAFP-12 did not differ significantly from that of the vehicle control. We conclude that DAFP-12 shows little or no tumor initiating activity for mouse skin even when coadministered with vitamin E. Topics: Adult; Animals; Drug Combinations; Female; Humans; Mice; Mutagens; Papilloma; Polyenes; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vitamin E	1991

Article

Year

Carcinogenicity study of fecapentaene-12 diacetate on skin painting in SENCAR mice.

Cancer letters, 1991, Volume: 56, Issue:1

To investigate the effects of both diol esterification and coadministration with antioxidant on the tumorigenicity of fecapentaene-12 (FP-12) preparations, diacetylfecapentaene-12 (DAFP-12) in dimethylsulfoxide (DMSO) was applied to SENCAR mouse skin with or without the stabilizer, vitamin E, twice/week for 5 weeks, following which all animals were promoted for up to 25 weeks by weekly applications of 12-O-tetradecanoylphorbol-13-acetate (TPA). While positive controls receiving 7,12-dimethylbenz[a]anthracene (DMBA) instead of DAFP-12 in a similar protocol all developed papillomas (average of 23/animal), papilloma incidence in mice given DAFP-12 did not differ significantly from that of the vehicle control. We conclude that DAFP-12 shows little or no tumor initiating activity for mouse skin even when coadministered with vitamin E.

Topics: Adult; Animals; Drug Combinations; Female; Humans; Mice; Mutagens; Papilloma; Polyenes; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vitamin E

1991