Compounds > 1-(1-glycero)dodeca-1-3-5-7-9-pentaene

1-(1-glycero)dodeca-1-3-5-7-9-pentaene and Cell-Transformation--Neoplastic

1-(1-glycero)dodeca-1-3-5-7-9-pentaene has been researched along with Cell-Transformation--Neoplastic* in 1 studies

Other Studies

1 other study(ies) available for 1-(1-glycero)dodeca-1-3-5-7-9-pentaene and Cell-Transformation--Neoplastic

Article	Year
Genotoxicity of fecapentaene-12 in bacterial and mammalian cell assay systems. Carcinogenesis, 1987, Volume: 8, Issue:2 Fecapentaene-12 (Fec-12), a compound thought to be responsible for much of the mutagenicity in fecal extracts from groups at high risk for colon cancer, was assayed for genotoxic potential in a battery of bacterial and mammalian cell short-term assays. This compound demonstrated significant mutagenic activity with Salmonella typhimurium tester strains TA104, TA100 and TA98, inducing approximately 1400, 700 and 100 revertants/micrograms, respectively. Fec-12 caused dose-dependent increases in unscheduled DNA synthesis in both rat hepatocytes and human fibroblasts, indicating its potential genotoxicity to mammalian as well as bacterial cells. Finally, Fec-12 had the ability to induce neoplastic transformation in mouse BALB/c 3T3 cells in the absence of exogenous metabolic activation. Topics: Animals; Cell Transformation, Neoplastic; DNA; DNA Repair; Humans; In Vitro Techniques; Male; Mice; Mutagenicity Tests; Polyenes; Rats; Salmonella typhimurium	1987

Article

Year

Genotoxicity of fecapentaene-12 in bacterial and mammalian cell assay systems.

Carcinogenesis, 1987, Volume: 8, Issue:2

Fecapentaene-12 (Fec-12), a compound thought to be responsible for much of the mutagenicity in fecal extracts from groups at high risk for colon cancer, was assayed for genotoxic potential in a battery of bacterial and mammalian cell short-term assays. This compound demonstrated significant mutagenic activity with Salmonella typhimurium tester strains TA104, TA100 and TA98, inducing approximately 1400, 700 and 100 revertants/micrograms, respectively. Fec-12 caused dose-dependent increases in unscheduled DNA synthesis in both rat hepatocytes and human fibroblasts, indicating its potential genotoxicity to mammalian as well as bacterial cells. Finally, Fec-12 had the ability to induce neoplastic transformation in mouse BALB/c 3T3 cells in the absence of exogenous metabolic activation.

Topics: Animals; Cell Transformation, Neoplastic; DNA; DNA Repair; Humans; In Vitro Techniques; Male; Mice; Mutagenicity Tests; Polyenes; Rats; Salmonella typhimurium

1987