(r)-n-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide and Long-QT-Syndrome

Topics: Animals; KCNQ1 Potassium Channel; Long QT Syndrome; Mutation; Piperidines; Thiazoles; Tosyl Compounds; Xenopus

Upon membrane depolarization, the KCNQ1 potassium channel opens at the intermediate (IO) and activated (AO) states of the stepwise voltage-sensing domain (VSD) activation. In the heart, KCNQ1 associates with KCNE1 subunits to form I

Topics: Animals; Cell Membrane; Cell Polarity; Humans; KCNQ1 Potassium Channel; Long QT Syndrome; Oocytes; Piperidines; Potassium; Potassium Channels, Voltage-Gated; Thiazoles; Tosyl Compounds; Xenopus

Healthy human heart rate fluctuates overtime showing long-range fractal correlations. In contrast, various cardiac diseases and normal aging show the breakdown of fractal complexity. Recently, it was shown that human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) intrinsically exhibit fractal behavior as in humans. Here, we investigated the fractal complexity of hiPSC-derived long QT-cardiomyocytes (LQT-CMs). We recorded extracellular field potentials from hiPSC-CMs at baseline and under the effect of various compounds including β-blocker bisoprolol, ML277, a specific and potent I

Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Bisoprolol; Cells, Cultured; Dose-Response Relationship, Drug; Female; Fractals; Heart Conduction System; Heart Rate; Humans; Induced Pluripotent Stem Cells; Long QT Syndrome; Myocytes, Cardiac; Piperidines; Thiazoles; Time Factors; Tosyl Compounds