(e)-3-(4-t-butylphenyl)-n-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide and Disease Models, Animal

Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries

Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection

Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Hyperalgesia; Male; Mice, Inbred C57BL; Oxidopamine; Pain Threshold; Parkinson Disease; Piperidines; Receptors, Serotonin, 5-HT3; Serotonin; Signal Transduction; Trigeminal Caudal Nucleus; TRPV Cation Channels

Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Male; Paclitaxel; Rats; RNA, Small Interfering; Spinal Cord; TRPV Cation Channels; Up-Regulation

Topics: Acetanilides; Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Acrylamides; Amiloride; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Male; Mice; Morphine; Pain Measurement; Purines; Random Allocation; Receptors, Atrial Natriuretic Factor; Receptors, Opioid; Stomach Ulcer; Transient Receptor Potential Channels; Visceral Pain

Topics: Acrylamides; Animals; Animals, Newborn; Antipruritics; Bridged Bicyclo Compounds, Heterocyclic; Dermatitis, Phototoxic; Disease Models, Animal; Evoked Potentials; HEK293 Cells; Humans; Hyperalgesia; Lidocaine; Lipid Metabolism; Menthol; Mice; Mice, Inbred C57BL; Neurons; Pain; Pain Threshold; Photochemotherapy; Reactive Oxygen Species; TRPV Cation Channels

Topics: Acetic Acid; Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Acrylamides; Amiloride; Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Calcitonin Gene-Related Peptide; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Pain; Phosphorylation; Proto-Oncogene Proteins c-fos; Trigeminal Nucleus, Spinal; TRPV Cation Channels

Topics: Acrylamides; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium-Binding Proteins; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Fish Venoms; Ganglia, Spinal; Gene Expression Regulation; Green Fluorescent Proteins; HEK293 Cells; Humans; Hyperalgesia; Luminescent Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Neurogenic Inflammation; Oncogene Proteins v-fos; Pain; Pain Measurement; Sensory Receptor Cells; Time Factors; Touch; TRPV Cation Channels

Topics: Acetaminophen; Acetanilides; Acrylamides; Animals; Anticonvulsants; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Kindling, Neurologic; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Piperidines; Purines; Pyrazoles; Seizures; Time Factors; TRPV Cation Channels

Topics: Acrylamides; Animals; Asthma; Bridged Bicyclo Compounds, Heterocyclic; Carotid Body; Disease Models, Animal; Drug Evaluation, Preclinical; Lysophospholipids; Male; Rats, Inbred BN; Rats, Sprague-Dawley; Receptors, Lysophosphatidic Acid; TRPV Cation Channels

Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Complement C5a; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Macrophages; Male; Mice; Mice, Inbred C57BL; Nerve Growth Factor; Pain Measurement; Piperidines; Quinazolines; Quinuclidines; Receptors, Calcitonin Gene-Related Peptide; Repressor Proteins; TRPA1 Cation Channel; TRPV Cation Channels

Topics: Acids; Acrylamides; Adenosine Diphosphate; Animals; Benzophenanthridines; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Diterpenes; Hindlimb; Hot Temperature; Hyperalgesia; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Injections; Ion Channels; Ischemia; Pain; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2Y1; Sodium Chloride; Thrombosis; Tissue Extracts; TRPV Cation Channels

Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium Signaling; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophilic Esophagitis; Esophagus; Guinea Pigs; Heartburn; Hydrogen-Ion Concentration; Male; Membrane Potentials; Nodose Ganglion; Ovalbumin; Time Factors; TRPV Cation Channels; Vagotomy; Vagus Nerve

Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Disease Models, Animal; Flushing; Mice; Mice, Knockout; Niacin; Sensory System Agents; TRPV Cation Channels; Vasodilation; Vasodilator Agents

Topics: Acrylamides; Amidohydrolases; Analgesia; Animals; Arachidonic Acid; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Carrageenan; Disease Models, Animal; Ethanolamines; Formaldehyde; Genotype; Hyperalgesia; Inflammation; Injections, Intraperitoneal; Ligands; Lumbar Vertebrae; Mice, Inbred C57BL; Mice, Knockout; Nociception; Pain; Pain Threshold; Phenotype; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Receptor, Cannabinoid, CB1; Skin; Spinal Cord Dorsal Horn; TRPV Cation Channels

Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Interleukin-10; Male; Neuroprotective Agents; Rats; Rats, Wistar; Stroke; TRPV Cation Channels; Tumor Necrosis Factor-alpha

Topics: Acrylamides; Afferent Pathways; Animals; Ankyrins; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channels; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Facial Pain; Hyperalgesia; Injections, Intramuscular; Male; Masticatory Muscles; Mustard Plant; Nociceptors; Pain Measurement; Pain Threshold; Plant Oils; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sensory System Agents; Trigeminal Ganglion; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels

Topics: Acrylamides; Adenosine Triphosphate; Adrenergic beta-Antagonists; Animals; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Enzyme Inhibitors; Female; Fluorescent Dyes; Heat Stress Disorders; Hyperalgesia; Lipoxygenase; Nitric Oxide Synthase; Purinergic P2 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Purinergic P2; Receptors, Purinergic P2X; TRPV Cation Channels

Topics: Acrylamides; Analysis of Variance; Animals; Area Under Curve; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Ganglia, Spinal; Hyperalgesia; Inflammation; Male; Mice; Oligodeoxyribonucleotides, Antisense; Pain Threshold; Physical Stimulation; RNA, Messenger; Spinal Cord; Transient Receptor Potential Channels; TRPA1 Cation Channel

Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cold Temperature; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Pain; Pyrazines; Pyridines; Pyrrolidines; Rats; Rats, Sprague-Dawley; TRPV Cation Channels; Urea

Topics: Abdominal Pain; Acetanilides; Acrylamides; Acute Disease; Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cells, Cultured; Disease Models, Animal; Ganglia, Spinal; Gene Expression; Male; Mice; Mice, Inbred C57BL; Nodose Ganglion; Pancreas; Pancreatitis; Patch-Clamp Techniques; Purines; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels

Topics: Acrylamides; Anilides; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Antioxidants; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cinnamates; Cromolyn Sodium; Disease Models, Animal; Diterpenes; Edema; Gabexate; Histamine; Male; Mast Cells; Methysergide; Pain; Promethazine; Prostaglandin-Endoperoxide Synthases; Protein Binding; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Serotonin; Serotonin Antagonists; Tritium; TRPV Cation Channels; Uric Acid

Topics: Acrylamides; Animals; Behavior, Animal; Blood Glucose; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Blockers; Capsaicin; Cell Line, Transformed; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Ganglia, Spinal; Gene Expression Regulation; Hot Temperature; Humans; Hyperalgesia; Inflammation; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Mustard Plant; Nifedipine; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Plant Oils; Pregnenolone; Sensory Receptor Cells; Telemetry; Time Factors; Transfection; Transient Receptor Potential Channels; Trigeminal Ganglion; TRPA1 Cation Channel; TRPM Cation Channels

Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acrylamides; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Disease Models, Animal; Docosahexaenoic Acids; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Freund's Adjuvant; Ganglia, Spinal; In Vitro Techniques; Inflammation; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pain; Pain Measurement; Patch-Clamp Techniques; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Spinal Cord; TRPV Cation Channels; Tumor Necrosis Factor-alpha

Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cognition; Disease Models, Animal; Male; Motor Activity; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; TRPV Cation Channels