(1S-3aR-4S-6S-6aS-9aS-9bS)-9a-isocyano-6-(2-isocyano-2-methylpropyl)-1-4-dimethyl-7-methylidene-2-3-3a-4-5-6-6a-8-9-9b-decahydro-1H-phenalene has been researched along with Prostatic-Neoplasms* in 1 studies
1 other study(ies) available for (1S-3aR-4S-6S-6aS-9aS-9bS)-9a-isocyano-6-(2-isocyano-2-methylpropyl)-1-4-dimethyl-7-methylidene-2-3-3a-4-5-6-6a-8-9-9b-decahydro-1H-phenalene and Prostatic-Neoplasms
| Article | Year |
|---|---|
Evaluation of the antiproliferative activity of diterpene isonitriles from the sponge Pseudoaxinella flava in apoptosis-sensitive and apoptosis-resistant cancer cell lines.
One new (1) and three known (2-4) isonitrile diterpenes, isolated from the Caribbean sponge Pseudoaxinella flava, were assayed in human cancer cell lines in vitro using an MTT colorimetric assay and quantitative videomicroscopy. Compounds 1-4 displayed activity for human PC3 prostate apoptosis-sensitive cancer cell lines. Compounds 3 and 4 demonstrated similar growth inhibitory effects for three apoptosis-sensitive and three apoptosis-resistant cancer cell lines. Quantitative videomicroscopy analysis revealed that compounds 1 and 2 exerted their activity through cytotoxic effects, and compounds 3 and 4 through cytostatic effects. These results identify marine diterpene isonitriles as potential lead compounds for anticancer drug discovery. Topics: Animals; Antineoplastic Agents; Apoptosis; Bahamas; Caribbean Region; Cytostatic Agents; Diterpenes; Humans; Male; Microscopy, Video; Molecular Structure; Nitriles; Porifera; Prostatic Neoplasms | 2011 |