(-)-pinoresinol and Diabetes-Mellitus--Type-2

(-)-pinoresinol has been researched along with Diabetes-Mellitus--Type-2* in 1 studies

Other Studies

1 other study(ies) available for (-)-pinoresinol and Diabetes-Mellitus--Type-2

Article	Year
(+)-Pinoresinol is a putative hypoglycemic agent in defatted sesame (Sesamum indicum) seeds though inhibiting α-glucosidase. Bioorganic & medicinal chemistry letters, 2012, Aug-15, Volume: 22, Issue:16 Defatted sesame seeds have been reported for hypoglycemic effect in mice and T2DM women. An attempted to identify active components responsible for this effect was conducted using α-glucosidase-guided fractionation, resulting in the isolation of various lignans. Of compounds isolated, only (+)-pinoresinol showed inhibitory activity against rat intestinal maltase with an IC(50) value of 34.3 μM. The kinetic study indicated that enzymatic hydrolysis of maltose is inhibited by (+)-pinoresinol through competitive and noncompetitive manners. However, a lower dissociation constant (k(i) 288 M) of EI complex suggested that competitive inhibition is predominant over noncompetitive mode (k'(i) 1342 M). Topics: alpha-Glucosidases; Animals; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Female; Furans; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Intestines; Kinetics; Lignans; Mice; Rats; Seeds; Sesamum; Stereoisomerism	2012

Article

Year

(+)-Pinoresinol is a putative hypoglycemic agent in defatted sesame (Sesamum indicum) seeds though inhibiting α-glucosidase.

Bioorganic & medicinal chemistry letters, 2012, Aug-15, Volume: 22, Issue:16

Defatted sesame seeds have been reported for hypoglycemic effect in mice and T2DM women. An attempted to identify active components responsible for this effect was conducted using α-glucosidase-guided fractionation, resulting in the isolation of various lignans. Of compounds isolated, only (+)-pinoresinol showed inhibitory activity against rat intestinal maltase with an IC(50) value of 34.3 μM. The kinetic study indicated that enzymatic hydrolysis of maltose is inhibited by (+)-pinoresinol through competitive and noncompetitive manners. However, a lower dissociation constant (k(i) 288 M) of EI complex suggested that competitive inhibition is predominant over noncompetitive mode (k'(i) 1342 M).

Topics: alpha-Glucosidases; Animals; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Female; Furans; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Intestines; Kinetics; Lignans; Mice; Rats; Seeds; Sesamum; Stereoisomerism

2012