Page last updated: 2024-08-16

zotepine and haloperidol

zotepine has been researched along with haloperidol in 40 studies

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-19906 (15.00)18.7374
1990's15 (37.50)18.2507
2000's10 (25.00)29.6817
2010's6 (15.00)24.3611
2020's3 (7.50)2.80

Authors

AuthorsStudies
Choudhary, MS; Craigo, SC; Meltzer, HY; Monsma, FJ; Roth, BL; Shen, Y; Sibley, DR; Uluer, A1
De Loore, K; Gommeren, W; Janssen, PF; Lesage, AS; Leysen, JE; Luyten, WH; Schotte, A; Van Gompel, P1
Wermuth, CG1
Jadhav, A; Kerns, E; Nguyen, K; Shah, P; Sun, H; Xu, X; Yan, Z; Yu, KR1
Kabir, M; Kerns, E; Nguyen, K; Shah, P; Sun, H; Wang, Y; Xu, X; Yu, KR1
Kabir, M; Kerns, E; Neyra, J; Nguyen, K; Nguyễn, ÐT; Shah, P; Siramshetty, VB; Southall, N; Williams, J; Xu, X; Yu, KR1
Itkin, M; Kabir, M; Mathé, EA; Nguyễn, ÐT; Padilha, EC; Shah, P; Shinn, P; Siramshetty, V; Wang, AQ; Williams, J; Xu, X; Yu, KR; Zhao, T1
Barnas, C; Fleischhacker, WW; Haring, C; Miller, C; Sperner-Unterweger, B; Stuppäck, CH2
Barnas, C; Fleischhacker, WW; Hinterhuber, H; Miller, C; Sperner-Unterweger, B; Stuppäck, CH1
Klieser, E; Lehmann, E; Tegeler, J1
Barnas, C; Fleischhacker, WW; Hinterhuber, H; Miller, C; Stuppäck, CH; Unterweger, B1
Harada, T; Otsuki, S; Sato, M1
Carino, MA; Horita, A; Lai, HC1
Carino, MA; Horita, A; Lai, H; Sperry, R1
Carino, MA; Horita, A; Lai, H1
Mori, J; Satoh, H; Satoh, Y1
Czyrak, A; Frankiewicz, T; Maj, J; Rogóz, Z; Skuza, G1
Matsubara, R1
Czyrak, A; Jaros, T; Maj, J; Moryl, E1
Behrens, S; Gattaz, WF; Schummer, B1
Ishikura, T; Jibiki, I; Kubota, T1
König, F; Straub, R; Wolfersdorf, M1
Dollfus, S; Kelly, F; Leutenegger, E; Petit, M; Raniwalla, J; Tweed, J1
Akiyama, K; Kuroda, S; Okumura, K; Ujike, H1
Heal, DJ; Kilpatrick, IC; Needham, PL; Rowley, HL1
Kapur, S; Remington, G1
Hilger, E; Kasper, S1
Hwang, TJ; Lin, HN; Lin, SK1
Lawrie, S; McIntosh, A; Nadeem, Z2
Bai, YM; Chen, JY; Lin, CC; Liou, YJ; Wang, YC1
Huang, CJ; Wang, PW; Wang, SY1
Hamaguchi, T; Matsumoto, T; Motomura, E; Nakagawa, M; Ohoyama, K; Okada, M; Shiroyama, T; Suzuki, D; Tanii, H; Yamamura, S1
Chan, HY; Chang, CJ; Chen, CH; Chen, JJ; Chiu, NY; Jou, SH; Juang, YY1
Fukui, N; Ono, S; Saito, M; Someya, T; Sugai, T; Suzuki, Y; Tsuneyama, N; Watanabe, J1
Chang, LR; Huang, WL1
Hejna, P; Ublová, M; Voříšek, V1
Hashimoto, N; Ishikawa, S; Ito, YM; Kusumi, I; Okubo, R; Sato, N; Sawagashira, R; Yamamura, R1

Reviews

6 review(s) available for zotepine and haloperidol

ArticleYear
Selective optimization of side activities: another way for drug discovery.
    Journal of medicinal chemistry, 2004, Mar-11, Volume: 47, Issue:6

    Topics: Animals; Biological Availability; Combinatorial Chemistry Techniques; Databases, Factual; Drug Design; Humans; Patents as Topic; Pharmaceutical Preparations; Structure-Activity Relationship

2004
Using in vitro ADME data for lead compound selection: An emphasis on PAMPA pH 5 permeability and oral bioavailability.
    Bioorganic & medicinal chemistry, 2022, 02-15, Volume: 56

    Topics: Administration, Oral; Animals; Betamethasone; Biological Availability; Caco-2 Cells; Cell Membrane Permeability; Cells, Cultured; Dexamethasone; Dogs; Dose-Response Relationship, Drug; Humans; Hydrogen-Ion Concentration; Madin Darby Canine Kidney Cells; Mice; Molecular Structure; Neural Networks, Computer; Ranitidine; Rats; Structure-Activity Relationship; Verapamil

2022
Atypical antipsychotics: new directions and new challenges in the treatment of schizophrenia.
    Annual review of medicine, 2001, Volume: 52

    Topics: Amisulpride; Antipsychotic Agents; Benzodiazepines; Clozapine; Dibenzothiazepines; Dibenzothiepins; Dopamine Antagonists; Drug Monitoring; Haloperidol; Humans; Imidazoles; Indoles; Olanzapine; Piperazines; Pirenzepine; Quetiapine Fumarate; Receptors, Dopamine D2; Receptors, Dopamine D4; Risperidone; Schizophrenia; Schizophrenic Psychology; Serotonin Antagonists; Sulpiride; Thiazoles; Treatment Outcome

2001
[Atypical neuroleptics: new approaches to drug therapy of schizophrenic disorders].
    Wiener klinische Wochenschrift, 2000, Dec-22, Volume: 112, Issue:24

    Topics: Aged; Amisulpride; Antipsychotic Agents; Benzodiazepines; Clozapine; Controlled Clinical Trials as Topic; Dibenzothiazepines; Dibenzothiepins; Haloperidol; Humans; Imidazoles; Indoles; Multicenter Studies as Topic; Olanzapine; Piperazines; Pirenzepine; Placebos; Quetiapine Fumarate; Risperidone; Schizophrenia; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Sulpiride; Thiazoles

2000
Schizophrenia.
    Clinical evidence, 2003, Issue:10

    Topics: Amisulpride; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; Cognitive Behavioral Therapy; Dibenzothiepins; Haloperidol; Humans; Olanzapine; Patient Compliance; Perazine; Pimozide; Risperidone; Schizophrenia; Sulpiride

2003
Schizophrenia.
    Clinical evidence, 2005, Issue:14

    Topics: Amisulpride; Antipsychotic Agents; Chlorpromazine; Clozapine; Cognitive Behavioral Therapy; Dibenzothiepins; Family Therapy; Haloperidol; Humans; Patient Compliance; Risperidone; Schizophrenia; Secondary Prevention; Sulpiride; Thioridazine

2005

Trials

8 trial(s) available for zotepine and haloperidol

ArticleYear
Zotepine in the treatment of schizophrenic patients with prevailingly negative symptoms. A double-blind trial vs. haloperidol.
    International clinical psychopharmacology, 1992,Spring, Volume: 7, Issue:1

    Topics: Adult; Antipsychotic Agents; Chronic Disease; Dibenzothiepins; Double-Blind Method; Female; Haloperidol; Humans; Male; Middle Aged; Schizophrenia; Schizophrenic Psychology

1992
[Zotepine vs. haloperidol in paranoid schizophrenia: a double-blind study].
    Fortschritte der Neurologie-Psychiatrie, 1991, Volume: 59 Suppl 1

    Topics: Adult; Antipsychotic Agents; Dibenzothiepins; Double-Blind Method; Dyskinesia, Drug-Induced; Female; Haloperidol; Hospitalization; Humans; Male; Neurologic Examination; Psychiatric Status Rating Scales; Schizophrenia, Paranoid

1991
[Double-blind comparison of 3 x 75 mg zotepine und 3 x 4 mg haloperidol in acute schizophrenic patients].
    Fortschritte der Neurologie-Psychiatrie, 1991, Volume: 59 Suppl 1

    Topics: Acute Disease; Adolescent; Adult; Antipsychotic Agents; Dibenzothiepins; Dose-Response Relationship, Drug; Double-Blind Method; Female; Haloperidol; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology

1991
[Zotepine: treatment of schizophrenic patients with predominantly negative symptoms. A double-blind study vs. haloperidol].
    Fortschritte der Neurologie-Psychiatrie, 1991, Volume: 59 Suppl 1

    Topics: Adult; Antipsychotic Agents; Chronic Disease; Dibenzothiepins; Double-Blind Method; Dyskinesia, Drug-Induced; Female; Haloperidol; Humans; Male; Middle Aged; Neurologic Examination; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology

1991
Zotepine vs. haloperidol in paranoid schizophrenia: a double-blind trial.
    Psychopharmacology bulletin, 1989, Volume: 25, Issue:1

    Topics: Adult; Antipsychotic Agents; Clinical Trials as Topic; Dibenzothiepins; Double-Blind Method; Female; Haloperidol; Humans; Male; Random Allocation; Schizophrenia

1989
A comparison of an atypical and typical antipsychotic, zotepine versus haloperidol in patients with acute exacerbation of schizophrenia: a parallel-group double-blind trial.
    Psychopharmacology bulletin, 1996, Volume: 32, Issue:1

    Topics: Adult; Antipsychotic Agents; Brief Psychiatric Rating Scale; Dibenzothiepins; Double-Blind Method; Female; Haloperidol; Humans; Male; Middle Aged; Schizophrenia

1996
Efficacy and safety of zotepine for the treatment of Taiwanese schizophrenic patients: a double-blind comparison with haloperidol.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2001, Volume: 100, Issue:12

    Topics: Adult; Antipsychotic Agents; Dibenzothiepins; Double-Blind Method; Female; Haloperidol; Humans; Male; Prospective Studies; Psychiatric Status Rating Scales; Schizophrenia

2001
A single-blind, comparative study of zotepine versus haloperidol in combination with a mood stabilizer for patients with moderate-to-severe mania.
    Psychiatry and clinical neurosciences, 2010, Volume: 64, Issue:2

    Topics: Adult; Aged; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Dibenzothiepins; Drug Administration Schedule; Female; Haloperidol; Humans; Intention to Treat Analysis; Male; Middle Aged; Patient Selection; Severity of Illness Index; Single-Blind Method; Treatment Outcome

2010

Other Studies

26 other study(ies) available for zotepine and haloperidol

ArticleYear
Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:3

    Topics: Animals; Antipsychotic Agents; Cell Line; Molecular Structure; Rats; Receptors, Serotonin

1994
Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding.
    Psychopharmacology, 1996, Volume: 124, Issue:1-2

    Topics: Animals; Antipsychotic Agents; Brain; Cells, Cultured; Clozapine; Haloperidol; Humans; Male; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Serotonin; Risperidone

1996
Highly predictive and interpretable models for PAMPA permeability.
    Bioorganic & medicinal chemistry, 2017, 02-01, Volume: 25, Issue:3

    Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Humans; Models, Biological; Organic Chemicals; Regression Analysis; Support Vector Machine

2017
Predictive models of aqueous solubility of organic compounds built on A large dataset of high integrity.
    Bioorganic & medicinal chemistry, 2019, 07-15, Volume: 27, Issue:14

    Topics: Drug Discovery; Organic Chemicals; Pharmaceutical Preparations; Solubility

2019
Retrospective assessment of rat liver microsomal stability at NCATS: data and QSAR models.
    Scientific reports, 2020, 11-26, Volume: 10, Issue:1

    Topics: Animals; Computer Simulation; Databases, Factual; Drug Discovery; High-Throughput Screening Assays; Liver; Machine Learning; Male; Microsomes, Liver; National Center for Advancing Translational Sciences (U.S.); Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Rats; Rats, Sprague-Dawley; Retrospective Studies; United States

2020
Neuroleptic drugs and 5HT1 receptor: different potencies of various neuroleptic drugs on 5HT1 receptors in discrete regions of the rat brain.
    Folia psychiatrica et neurologica japonica, 1985, Volume: 39, Issue:4

    Topics: Animals; Antipsychotic Agents; Brain; Chlorpromazine; Dibenzothiepins; Haloperidol; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiperone

1985
Effects of chronic haloperidol, thioridazine and zotepine treatment on apomorphine elicited stereotypic behavior and 3H-spiroperidol binding sites in the striatum of the rat.
    Proceedings of the Western Pharmacology Society, 1981, Volume: 24

    Topics: Animals; Antipsychotic Agents; Apomorphine; Binding Sites; Butyrophenones; Corpus Striatum; Dibenzothiepins; Haloperidol; Humans; Male; Rats; Spiperone; Stereotyped Behavior; Thioridazine

1981
Effects of microinjection of 2-chloro-11 (2-dimethylaminoethoxy)-dibenzo[b,f]-thiepine (zotepine), thioridazine and haloperidol into the striatum and nucleus accumbens on stereotypic behaviour and motor activity.
    The Journal of pharmacy and pharmacology, 1981, Volume: 33, Issue:4

    Topics: Animals; Antipsychotic Agents; Atropine; Corpus Striatum; Dibenzothiepins; Haloperidol; Humans; Male; Microinjections; Motor Activity; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Dopamine; Septal Nuclei; Stereotyped Behavior; Thioridazine

1981
Chronic treatments with zotepine, thioridazine, and haloperidol affect apomorphine-elicited stereotypic behavior and striatal 3H-spiroperidol binding sites in the rat.
    Psychopharmacology, 1981, Volume: 75, Issue:4

    Topics: Animals; Antipsychotic Agents; Apomorphine; Binding Sites; Butyrophenones; Corpus Striatum; Dibenzothiepins; Drug Interactions; Haloperidol; Humans; Male; Rats; Rats, Inbred Strains; Spiperone; Stereotyped Behavior; Thioridazine

1981
Effect of zotepine and various drugs on apomorphine- and methamphetamine-induced rotational behaviour in rats with unilateral lesions of the substantia nigra.
    Japanese journal of pharmacology, 1983, Volume: 33, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Apomorphine; Atropine; Behavior, Animal; Diazepam; Dibenzothiepins; Fluphenazine; Haloperidol; Male; Methamphetamine; Rats; Rats, Inbred Strains; Substantia Nigra

1983
Pharmacological action of zotepine and other antipsychotics on central 5-hydroxytryptamine receptor subtypes.
    Arzneimittel-Forschung, 1994, Volume: 44, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Behavior, Animal; Body Temperature; Clozapine; Dibenzothiepins; Exploratory Behavior; Haloperidol; Isoxazoles; Male; Mice; Motor Activity; Piperazines; Piperidines; Rats; Rats, Wistar; Receptors, Serotonin; Risperidone; Serotonin Antagonists; Serotonin Receptor Agonists

1994
[A study on the pharmacological properties of atypical antipsychotic drugs: in vivo dopamine and serotonin receptor occupancy by atypical antipsychotic drugs in the rat brain].
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1993, Volume: 68, Issue:4

    Topics: Animals; Antipsychotic Agents; Autoradiography; Brain; Chlorpromazine; Clozapine; Dibenzothiepins; Flupenthixol; Haloperidol; In Vitro Techniques; Isoxazoles; Male; Piperidines; Pyrimidinones; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Serotonin; Risperidone

1993
Pharmacological effects of zotepine and other antipsychotics on the central 5-HT2 receptors.
    Pharmacopsychiatry, 1993, Volume: 26, Issue:2

    Topics: Animals; Antipsychotic Agents; Clozapine; Dibenzothiepins; Haloperidol; Isoxazoles; Male; Piperidines; Rats; Rats, Wistar; Receptors, Serotonin; Risperidone

1993
Effects of zotepine, haloperidol and clozapine on MK-801-induced stereotypy and locomotion in rats.
    Journal of neural transmission. General section, 1994, Volume: 96, Issue:3

    Topics: Animals; Antipsychotic Agents; Clozapine; Dibenzothiepins; Dizocilpine Maleate; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Motor Activity; Rats; Rats, Wistar; Stereotyped Behavior

1994
Three cases of alopecia areata induced by zotepine.
    Acta neurologica, 1993, Volume: 15, Issue:3

    Topics: Adult; Alopecia; Alopecia Areata; Antipsychotic Agents; Autoimmune Diseases; Carbamazepine; Clomipramine; Depressive Disorder; Diagnosis, Differential; Dibenzothiepins; Female; Haloperidol; Humans; Middle Aged; Schizophrenia

1993
Pharmacotherapy of delusional depression: experience with combinations of antidepressants with the neuroleptics zotepine and haloperidol.
    Neuropsychobiology, 1994, Volume: 29, Issue:4

    Topics: Adult; Amitriptyline; Antipsychotic Agents; Delusions; Depressive Disorder; Dibenzothiepins; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Haloperidol; Humans; Male; Maprotiline; Middle Aged; Psychiatric Status Rating Scales

1994
BMY-14802 reversed the sigma receptor agonist-induced neck dystonia in rats.
    Journal of neural transmission (Vienna, Austria : 1996), 1996, Volume: 103, Issue:10

    Topics: Animals; Antipsychotic Agents; Dibenzothiepins; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dystonia; Guanidines; Haloperidol; Male; Microinjections; Nerve Tissue Proteins; Perphenazine; Piperidines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, sigma; Red Nucleus; Sulpiride; Torticollis

1996
[Zotepin--its value and potentials for further development].
    Der Nervenarzt, 1994, Volume: 65, Issue:7 Suppl

    Topics: Animals; Antipsychotic Agents; Clozapine; Dibenzothiepins; Disease Models, Animal; Haloperidol; Humans; Rats; Schizophrenia

1994
A comparison of the acute effects of zotepine and other antipsychotics on rat cortical dopamine release, in vivo.
    Naunyn-Schmiedeberg's archives of pharmacology, 2000, Volume: 361, Issue:2

    Topics: Animals; Antipsychotic Agents; Benzodiazepines; Dibenzothiepins; Dopamine; Fluoxetine; Frontal Lobe; Haloperidol; Male; Microdialysis; Olanzapine; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Serotonin

2000
Treatment of clozapine-associated tardive dyskinesia.
    Progress in neuro-psychopharmacology & biological psychiatry, 2008, Feb-15, Volume: 32, Issue:2

    Topics: Adult; Anti-Dyskinesia Agents; Antipsychotic Agents; Clozapine; Cross-Over Studies; Dibenzothiepins; Dyskinesia, Drug-Induced; Female; Haloperidol; Humans; Male; Schizophrenia; Schizophrenic Psychology; Severity of Illness Index; Substance Withdrawal Syndrome; Treatment Outcome

2008
Zotepine-induced spontaneous ejaculation.
    International journal of clinical pharmacology and therapeutics, 2008, Volume: 46, Issue:11

    Topics: Adult; Antipsychotic Agents; Dibenzothiepins; Ejaculation; Genital Diseases, Male; Haloperidol; Humans; Male; Schizophrenia

2008
Effects of zotepine on extracellular levels of monoamine, GABA and glutamate in rat prefrontal cortex.
    British journal of pharmacology, 2009, Volume: 157, Issue:4

    Topics: Action Potentials; Animals; Antipsychotic Agents; Biogenic Monoamines; Dibenzothiepins; Drug Interactions; gamma-Aminobutyric Acid; Glutamic Acid; Haloperidol; Locus Coeruleus; Male; Mediodorsal Thalamic Nucleus; Neurons; Prefrontal Cortex; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Ventral Tegmental Area

2009
Improvement in QTc prolongation induced by zotepine following a switch to perospirone.
    Psychiatry and clinical neurosciences, 2012, Volume: 66, Issue:3

    Topics: Antipsychotic Agents; Dibenzothiepins; Electrocardiography; Female; Haloperidol; Heart Rate; Humans; Isoindoles; Long QT Syndrome; Middle Aged; Schizophrenia; Thiazoles; Water-Electrolyte Imbalance

2012
Hyperhidrosis under combination of zotepine and haloperidol alleviated by aripiprazole.
    Psychiatry and clinical neurosciences, 2012, Volume: 66, Issue:3

    Topics: Antipsychotic Agents; Aripiprazole; Diabetes Complications; Dibenzothiepins; Dopamine; Drug Interactions; Female; Haloperidol; Humans; Hyperhidrosis; Middle Aged; Piperazines; Quinolones; Schizophrenia

2012
Black esophagus: acute esophageal necrosis in fatal haloperidol intoxication.
    Journal of forensic sciences, 2013, Volume: 58, Issue:5

    Topics: Antipsychotic Agents; Chlorprothixene; Dibenzothiepins; Esophagus; Female; Forensic Pathology; Haloperidol; Humans; Middle Aged; Mucous Membrane; Necrosis

2013
The type rather than the daily dose or number of antipsychotics affects the incidence of hyperglycemic progression.
    Progress in neuro-psychopharmacology & biological psychiatry, 2022, 03-08, Volume: 113

    Topics: Adult; Antipsychotic Agents; Clozapine; Dibenzothiepins; Female; Haloperidol; Humans; Hyperglycemia; Incidence; Japan; Male; Middle Aged; Piperazines; Piperidines; Prospective Studies; Schizophrenia

2022