zopolrestat has been researched along with thiazoles in 37 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 25 (67.57) | 18.2507 |
2000's | 12 (32.43) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Aldinger, CE; Beyer, TA; Dee, MF; Mylari, BL; Scott, PJ; Siegel, TW; Zembrowski, WJ | 1 |
Inskeep, PB; Reed, AE; Ronfeld, RA | 1 |
Aldinger, CE; Beyer, TA; Dee, MF; Larson, ER; Mylari, BL; Siegel, TW; Singleton, DH; Zembrowski, WJ | 1 |
Chang, K; Corbett, JA; Currie, MG; Hasan, KS; McDaniel, ML; Misko, TP; Moore, WM; Petrash, JM; Smith, SR; Tilton, RG | 1 |
Gerber, N; Inskeep, PB; Peterson, MJ; Ronfeld, RA | 1 |
Petrash, JM; Quiocho, FA; Tarle, I; Wilson, DK | 1 |
Cohen, RA; Gupta, S; Oates, PJ; Ruderman, NB; Tesfamariam, B | 1 |
Nakano, T; Petrash, JM | 1 |
Beyer-Mears, A; Cruz, E; Diecke, FP; Mistry, K | 2 |
Oates, PJ; Ramasamy, R; Schaefer, S | 1 |
Ishii, A; Konishi, Y; Kotani, T; Nagaki, Y; Okamoto, K; Okukado, N; Suehiro, S; Yago, H | 1 |
Nakano, T; Petrash, JM; Quiocho, FA; Wilson, DK | 1 |
Eichberg, J; Kuruvilla, R | 1 |
Ramasamy, R; Trueblood, N | 1 |
Ramasamy, R; Schaefer, S; Trueblood, N | 1 |
Carper, DA; El-Kabbani, O; Hohman, TC; Lai, K; Malamas, MS; McGowan, MH; Putilina, T; Wane, YQ | 1 |
Fouda, HG; Inskeep, PB; Schneider, RP | 1 |
Davenport, CJ; Hoffmaster, KA; Inskeep, PB; Schneider, RP | 1 |
Cussac, M; Fresneau, P; Leclerc, G; Morand, JM; Szymonski, B; Tranqui, D | 1 |
Beaudet, LN; Dorsey, DA; Ido, Y; Plurad, SB; Schmidt, RE; Williamson, JR | 1 |
Goronzy, JJ; Hafner, V; Klimiuk, PA; Rittner, HL; Szweda, LI; Weyand, CM | 1 |
Liu, H; Oates, PJ; Ramasamy, R; Schaefer, S | 1 |
Arezzo, JC | 1 |
Flynn, TG; Hyndman, D; Jia, Z; Li, X; Ye, Q | 1 |
Kim, JY; Lee, SH; Moon, CH; Woo, HG | 1 |
Carper, DA; Hohman, TC; Kitchen, D; Malamas, MS; Nilakantan, R; Singh, SB | 1 |
Ellery, CA; Knight, DR; MacAndrew, JT; Magee, WP; Oates, PJ; Smith, AH; Tracey, WR | 1 |
Barth, P; Chung, RP; El-Kabbani, O; Fletcher, EV; Podjarny, A; Rogniaux, H; Van Dorsselaer, A | 1 |
Bakr, S; Hwang, YC; Oates, PJ; Ramasamy, R; Sato, S; Tsai, JY; Yan, S; Zhang, H | 1 |
Chough, E; Daley, J; Gupta, S; Keaney, JF; Oates, P; Ruderman, NB; Tornheim, K | 1 |
Bartlett, T; Demaine, AG; Hodgkinson, AD; Millward, BA; Oates, PJ | 1 |
Alexander, GD; Isales, CM; Marrero, MB; Redd, H; Shaw, S; Wang, X | 1 |
Chyun, DA; Johnson, BF; Law, G; Nesto, RW; Pfeifer, MA; Slater, WR; Vinik, AI; Wackers, FJ; Young, LH | 1 |
Chung, SK; Chung, SS; Dan, Q; Lam, KS; Wong, R | 1 |
Aberra, M; Aten, J; Deira, G; Dragt, CA; Krediet, RT; van Westrhenen, R | 1 |
Che, Q; Jiang, T; Li, H; Lin, Y; Zhang, N | 1 |
1 review(s) available for zopolrestat and thiazoles
Article | Year |
---|---|
New developments in the diagnosis of diabetic neuropathy.
Topics: Aldehyde Reductase; Axons; Benzothiazoles; Biopsy; Controlled Clinical Trials as Topic; Diabetic Neuropathies; Diagnosis, Differential; Electrophysiology; Enzyme Inhibitors; Humans; Immunohistochemistry; Neural Conduction; Peripheral Nerves; Phthalazines; Skin; Thiazoles | 1999 |
2 trial(s) available for zopolrestat and thiazoles
Article | Year |
---|---|
Pharmacokinetics of the aldose reductase inhibitor, zopolrestat, in humans.
Topics: Administration, Oral; Adolescent; Adult; Aldehyde Reductase; Benzothiazoles; Double-Blind Method; Drug Administration Schedule; Half-Life; Humans; Hypoglycemic Agents; Male; Metabolic Clearance Rate; Phthalazines; Thiazoles | 1994 |
Cardiac abnormalities in diabetic patients with neuropathy: effects of aldose reductase inhibitor administration.
Topics: Aldehyde Reductase; Benzothiazoles; Cardiac Output; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; Enzyme Inhibitors; Exercise Test; Female; Heart; Heart Conduction System; Heart Rate; Humans; Male; Middle Aged; Phthalazines; Placebos; Stroke Volume; Thiazoles; Ventricular Function, Left | 2004 |
34 other study(ies) available for zopolrestat and thiazoles
Article | Year |
---|---|
Potent, orally active aldose reductase inhibitors related to zopolrestat: surrogates for benzothiazole side chain.
Topics: Administration, Oral; Aldehyde Reductase; Animals; Benzothiazoles; Humans; Hypoglycemic Agents; Phthalazines; Rats; Structure-Activity Relationship; Thiazoles | 1992 |
Pharmacokinetics of zopolrestat, a carboxylic acid aldose reductase inhibitor, in normal and diabetic rats.
Topics: Administration, Oral; Aldehyde Reductase; Animals; Benzothiazoles; Blood Proteins; Diabetes Mellitus, Experimental; Drug Administration Schedule; Hypoglycemic Agents; Injections, Intravenous; Male; Phthalazines; Protein Binding; Rats; Rats, Inbred Strains; Thiazoles | 1991 |
Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl] methyl]-1-phthalazineacetic acid (zopolrestat) and congeners.
Topics: Aldehyde Reductase; Animals; Benzothiazoles; Enzyme Inhibitors; Female; Humans; Indicators and Reagents; Kinetics; Lens, Crystalline; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Phthalazines; Placenta; Pregnancy; Rats; Structure-Activity Relationship; Thiazoles; X-Ray Diffraction | 1991 |
Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation.
Topics: Aldehyde Reductase; Amino Acid Oxidoreductases; Animals; Arginine; Benzothiazoles; Blood Pressure; Body Weight; Capillary Permeability; Citrulline; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Glycation End Products, Advanced; Guanidines; Imidazoles; Imidazolidines; Inositol; Iodine Radioisotopes; Male; Methylguanidine; Naphthalenes; Nitric Oxide Synthase; omega-N-Methylarginine; Phthalazines; Rats; Rats, Sprague-Dawley; Retina; Sciatic Nerve; Serum Albumin, Bovine; Sorbitol; Thiazoles; Uvea | 1993 |
Refined 1.8 A structure of human aldose reductase complexed with the potent inhibitor zopolrestat.
Topics: Aldehyde Reductase; Amino Acid Sequence; Benzothiazoles; Binding Sites; Humans; Models, Molecular; Molecular Structure; NADP; Phthalazines; Protein Conformation; Protein Structure, Secondary; Recombinant Proteins; Thiazoles; X-Ray Diffraction | 1993 |
Reduced Na(+)-K+ pump activity in diabetic rabbit carotid artery: reversal by aldose reductase inhibition.
Topics: Aldehyde Reductase; Animals; Benzothiazoles; Carotid Arteries; Diabetes Mellitus, Experimental; In Vitro Techniques; Male; Ouabain; Phthalazines; Potassium; Rabbits; Rubidium; Sodium-Potassium-Exchanging ATPase; Thiazoles; Vasoconstriction; Vasodilation | 1993 |
Kinetic and spectroscopic evidence for active site inhibition of human aldose reductase.
Topics: Aldehyde Reductase; Benzothiazoles; Binding Sites; Enzyme Inhibitors; Glyceraldehyde; Humans; Hydantoins; Imidazoles; Imidazolidines; Kinetics; Phthalazines; Protein Binding; Recombinant Proteins; Spectrometry, Fluorescence; Thermodynamics; Thiazoles | 1996 |
Zopolrestat prevention of proteinuria, albuminuria and cataractogenesis in diabetes mellitus.
Topics: Albuminuria; Aldehyde Reductase; Animals; Benzothiazoles; Cataract; Chromatography, Gas; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Eye; Glucose; Lens, Crystalline; Male; Ouabain; Phthalazines; Potassium; Proteinuria; Rats; Rats, Sprague-Dawley; Rubidium; Sodium-Potassium-Exchanging ATPase; Thiazoles | 1996 |
Aldose reductase inhibition protects diabetic and nondiabetic rat hearts from ischemic injury.
Topics: Adenosine Triphosphate; Aldehyde Reductase; Animals; Benzothiazoles; Blood Glucose; Diabetes Mellitus, Type 1; Energy Metabolism; Enzyme Inhibitors; Fructose; Hydrogen-Ion Concentration; Lactates; Magnetic Resonance Spectroscopy; Myocardial Ischemia; Myocardium; NAD; Phthalazines; Pyruvates; Rats; Rats, Inbred BB; Reperfusion Injury; Sorbitol; Thiazoles | 1997 |
Highly selective aldose reductase inhibitors. 3. Structural diversity of 3-(arylmethyl)-2,4,5-trioxoimidazolidine-1-acetic acids.
Topics: Acetates; Aldehyde Reductase; Animals; Benzothiazoles; Diabetes Complications; Enzyme Inhibitors; Humans; Imidazoles; Kidney; Lens, Crystalline; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Phthalazines; Pyrimidinones; Rats; Sorbitol; Structure-Activity Relationship; Thiazoles | 1997 |
Structural studies of aldo-keto reductase inhibition.
Topics: Aldehyde Reductase; Benzothiazoles; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Models, Structural; NADP; Phthalazines; Protein Structure, Secondary; Recombinant Proteins; Thiazoles | 1997 |
Comparison of the effects of Zopolrestat and Sorbinil on lens myo-inositol influx.
Topics: Aldehyde Reductase; Animals; Benzothiazoles; Carbohydrate Metabolism; Carbohydrates; Culture Media; Enzyme Inhibitors; Galactose; Glucose; Imidazoles; Imidazolidines; In Vitro Techniques; Inositol; Lens, Crystalline; Male; Phthalazines; Polymers; Rats; Rats, Sprague-Dawley; Sorbitol; Thiazoles | 1997 |
Depletion of phospholipid arachidonoyl-containing molecular species in a human Schwann cell line grown in elevated glucose and their restoration by an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Arachidonic Acid; Benzothiazoles; Cell Division; Culture Media; Enzyme Inhibitors; Fructose; Glucose; Humans; Imidazoles; Imidazolidines; L-Iditol 2-Dehydrogenase; Mannitol; Neurofibroma; Organic Chemicals; Phospholipids; Phthalazines; Piperazines; Pyrimidines; Schwann Cells; Sorbitol; Thiazoles; Tumor Cells, Cultured | 1998 |
Aldose reductase inhibition improves altered glucose metabolism of isolated diabetic rat hearts.
Topics: Aldehyde Reductase; Animals; Benzothiazoles; Blood Pressure; Citric Acid Cycle; Diabetes Mellitus, Type 1; Enzyme Inhibitors; Glucose; Glyceraldehyde 3-Phosphate; Glycolysis; Heart; Heart Rate; In Vitro Techniques; Models, Chemical; Myocardium; Phthalazines; Rats; Rats, Inbred BB; Reference Values; Thiazoles | 1998 |
Metabolic effects of aldose reductase inhibition during low-flow ischemia and reperfusion.
Topics: Aldehyde Reductase; Animals; Benzothiazoles; Cytosol; Diabetes Mellitus, Type 1; Enzyme Inhibitors; Glycolysis; Heart; Hydrogen-Ion Concentration; In Vitro Techniques; Lactates; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Oxidation-Reduction; Phthalazines; Pyruvates; Rats; Rats, Inbred BB; Reference Values; Sorbitol; Thiazoles; Ventricular Function, Left | 1998 |
Probing the inhibitor-binding site of aldose reductase with site-directed mutagenesis.
Topics: Aldehyde Reductase; Benzothiazoles; Binding Sites; Computer Simulation; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Kinetics; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; NADP; Naphthalenes; Phthalazines; Recombinant Proteins; Thiazoles | 1998 |
Tissue distribution and biotransformation of zopolrestat, an aldose reductase inhibitor, in rats.
Topics: Administration, Oral; Aldehyde Reductase; Animals; Benzothiazoles; Bile Ducts; Biotransformation; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Female; Half-Life; Hypoglycemic Agents; Male; Mass Spectrometry; Phthalazines; Rats; Rats, Long-Evans; Thiazoles; Tissue Distribution | 1998 |
Bioavailability, multiple-dose pharmacokinetics, and biotransformation of the aldose reductase inhibitor zopolrestat in dogs.
Topics: Administration, Oral; Aldehyde Reductase; Animals; Benzothiazoles; Biological Availability; Biotransformation; Dogs; Drug Administration Schedule; Enzyme Inhibitors; Female; Half-Life; Hypoglycemic Agents; Male; Mass Spectrometry; Phthalazines; Thiazoles | 1998 |
Synthesis, activity, and molecular modeling of new 2, 4-dioxo-5-(naphthylmethylene)-3-thiazolidineacetic acids and 2-thioxo analogues as potent aldose reductase inhibitors.
Topics: Acetates; Aldehyde Reductase; Animals; Benzothiazoles; Cattle; Crystallography, X-Ray; Enzyme Inhibitors; Lens, Crystalline; Models, Molecular; Phthalazines; Structure-Activity Relationship; Thiazoles | 1998 |
Effect of sorbitol dehydrogenase inhibition on experimental diabetic autonomic neuropathy.
Topics: Animals; Autonomic Nervous System Diseases; Benzothiazoles; Diabetic Neuropathies; Drug Evaluation, Preclinical; Enzyme Inhibitors; Ganglia, Sympathetic; L-Iditol 2-Dehydrogenase; Male; Mesentery; Neuroaxonal Dystrophies; Phthalazines; Piperazines; Pyrimidines; Rats; Rats, Sprague-Dawley; Thiazoles | 1998 |
Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis.
Topics: Aldehyde Reductase; Aldehydes; Animals; Apoptosis; Benzothiazoles; Chimera; Enzyme Inhibitors; Free Radical Scavengers; Giant Cell Arteritis; Humans; Imidazoles; Imidazolidines; Lipid Peroxidation; Mice; Mice, SCID; Phthalazines; RNA, Messenger; Temporal Arteries; Thiazoles; Up-Regulation; Vasculitis | 1999 |
Attenuation of ischemia induced increases in sodium and calcium by the aldose reductase inhibitor zopolrestat.
Topics: Aldehyde Reductase; Analysis of Variance; Animals; Benzothiazoles; Calcium; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Intracellular Fluid; Magnetic Resonance Spectroscopy; Metals; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Perfusion; Phthalazines; Rats; Rats, Inbred BB; Sodium; Sodium-Potassium-Exchanging ATPase; Thiazoles; Time Factors | 1999 |
Crystal structure of CHO reductase, a member of the aldo-keto reductase superfamily.
Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Animals; Benzothiazoles; Catalytic Domain; CHO Cells; Cricetinae; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Sequence Data; NADP; Phthalazines; Protein Conformation; Sequence Homology, Amino Acid; Thiazoles | 2000 |
Augmentation effects of high glucose on endotoxin-induced nitric oxide production in murine macrophages.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldehyde Reductase; Animals; Benzothiazoles; Cell Line; Drug Synergism; Enzyme Inhibitors; Glucose; Lipopolysaccharides; Macrophages; Mice; NAD; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phthalazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thiazoles | 1999 |
Molecular modeling of the aldose reductase-inhibitor complex based on the X-ray crystal structure and studies with single-site-directed mutants.
Topics: Aldehyde Reductase; Benzothiazoles; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Models, Molecular; Mutagenesis, Site-Directed; Phthalazines; Recombinant Proteins; Structure-Activity Relationship; Thiazoles | 2000 |
Aldose reductase inhibition alone or combined with an adenosine A(3) agonist reduces ischemic myocardial injury.
Topics: Adenosine; Aldehyde Reductase; Animals; Benzothiazoles; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Male; Myocardial Ischemia; Myocardium; Phthalazines; Purinergic P1 Receptor Agonists; Rabbits; Receptor, Adenosine A3; Sorbitol; Thiazoles | 2000 |
Aldose and aldehyde reductases: correlation of molecular modeling and mass spectrometric studies on the binding of inhibitors to the active site.
Topics: Aldehyde Reductase; Animals; Benzothiazoles; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Inhibitory Concentration 50; Models, Molecular; Naphthalenes; Phthalazines; Spectrometry, Mass, Electrospray Ionization; Swine; Thiazoles | 2000 |
Aldose reductase activation is a key component of myocardial response to ischemia.
Topics: Aldehyde Reductase; Animals; Benzothiazoles; Enzyme Inhibitors; Glucose; Myocardial Ischemia; Myocardium; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Phthalazines; Rats; Thiazoles | 2002 |
Hyperglycemia increases endothelial superoxide that impairs smooth muscle cell Na+-K+-ATPase activity.
Topics: Aldehyde Reductase; Animals; Aorta; Arginine; Benzothiazoles; Endothelium, Vascular; Enzyme Inhibitors; Free Radical Scavengers; Glucose; Hyperglycemia; In Vitro Techniques; Muscle, Smooth, Vascular; Phthalazines; Pyrogallol; Rabbits; Sodium-Potassium-Exchanging ATPase; Sorbitol; Superoxide Dismutase; Superoxides; Thiazoles | 2002 |
The response of antioxidant genes to hyperglycemia is abnormal in patients with type 1 diabetes and diabetic nephropathy.
Topics: Adult; Aged; Aldehyde Reductase; Antioxidants; Benzothiazoles; Blood Glucose; Catalase; Cells, Cultured; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Enzyme Inhibitors; Female; Gene Expression; Genetic Predisposition to Disease; Glutathione Peroxidase; Humans; Hyperglycemia; Leukocytes, Mononuclear; Male; Middle Aged; Phthalazines; Polymorphism, Genetic; RNA; RNA, Messenger; Superoxide Dismutase; Thiazoles | 2003 |
High glucose augments the angiotensin II-induced activation of JAK2 in vascular smooth muscle cells via the polyol pathway.
Topics: Acetophenones; Aldehyde Reductase; Angiotensin II; Animals; Antibodies; Aorta; Benzothiazoles; Cells, Cultured; Drug Synergism; Electroporation; Enzyme Inhibitors; Glucose; Intracellular Signaling Peptides and Proteins; Janus Kinase 2; Muscle, Smooth, Vascular; NADPH Oxidases; Oligonucleotides, Antisense; Phosphoproteins; Phosphorylation; Phthalazines; Polymers; Protein Kinase C; Protein Kinase C beta; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Reactive Oxygen Species; Thiazoles; Tyrosine; Vasoconstrictor Agents | 2003 |
Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell migration and monocyte adhesion.
Topics: Aldehyde Reductase; Animals; Antigens, CD; Aorta, Thoracic; Benzothiazoles; Blotting, Northern; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Chemokine CCL2; Enzyme Inhibitors; Female; Glycation End Products, Advanced; Male; Mice; Mice, Transgenic; Monocytes; Muscle, Smooth, Vascular; Nerve Tissue Proteins; Oligoribonucleotides, Antisense; Phthalazines; Polymers; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serum Albumin, Bovine; Thiazoles | 2004 |
Effects of inhibition of the polyol pathway during chronic peritoneal exposure to a dialysis solution.
Topics: Aldehyde Reductase; Animals; Benzothiazoles; Dialysis Solutions; Enzyme Inhibitors; Fibrosis; Glucose; Infusions, Parenteral; Lactic Acid; Male; Models, Animal; Neovascularization, Pathologic; Peritoneal Dialysis; Peritoneal Diseases; Peritoneum; Phthalazines; Polymers; Rats; Signal Transduction; Thiazoles | 2005 |
Aldose reductase regulates TGF-beta1-induced production of fibronectin and type IV collagen in cultured rat mesangial cells.
Topics: Aldehyde Reductase; Animals; Benzothiazoles; Cells, Cultured; Collagen Type IV; Fibronectins; Imidazolidines; MAP Kinase Signaling System; Mesangial Cells; Phthalazines; Rats; Signal Transduction; Smad2 Protein; Thiazoles; Transcription Factor AP-1; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2006 |