Page last updated: 2024-08-16

zonisamide and valproic acid

zonisamide has been researched along with valproic acid in 65 studies

Research

Studies (65)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.54)	18.7374
1990's	12 (18.46)	18.2507
2000's	26 (40.00)	29.6817
2010's	16 (24.62)	24.3611
2020's	10 (15.38)	2.80

Authors

Authors	Studies
Bruno-Blanch, L; Gálvez, J; García-Domenech, R	1
Huber, VJ; Kwee, IL; Nakada, T; Tsujita, M	1
Bialer, M; Shimshoni, JA; Yagen, B	1
Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Fukuchi, H; Kimura, M; Kimura, Y; Kitaura, T; Miyake, K; Tanaka, N	2
Fujita, T; Takano, K; Tanaka, S; Tanaka, T; Yonemasu, Y	1
Kakegawa, N; Seino, M	1
Miura, H	2
Akaho, R	1
Akita, M; Hasegawa, M; Hasegawa, T; Nabeshima, T; Shinoda, M	1
Eguchi, T; Fujita, N; Kishi, T; Ueda, K	1
Wallace, SJ	1
Kawasaki, J; Mima, T; Saida, K; Shibasaki, H; Takigawa, T	1
Fujitani, B; Kikuta, C; Masuda, Y; Minato, H	1
Akimitsu, T; Arita, K; Hamasaki, M; Hanaya, R; Hibino, S; Iida, K; Kurisu, K; Pant, B; Shinagawa, S	1
Hagan, RM; Higgins, GA; Kirkby, D; Southam, E	1
Akasaki, Y; Hashiguchi, W; Nagatomo, I; Takigawa, M; Tominaga, M; Uchida, M	1
Ando, Y; Asai, S; Hotta, T; Kobayashi, H; Miyachi, H	1
Kurokawa, T	1
Shelton, RC	1
Araki, H; Futagami, K; Gomita, Y; Hashimoto, Y; Kawasaki, H	1
Fujiwara, T; Iinuma, K	1
Frediani, F	1
Fukuoka, N; Kimura, M; Morita, S; Tsukamoto, T; Uno, J	1
Hardison, H; Khurana, DS; Kothare, SV; Legido, A; Melvin, JJ; Valencia, I	1
Pucci, V; Raggi, MA	1
Brodie, M; Grundy, JS; Levy, RH; Ragueneau-Majlessi, I; Shah, J; Smith, D	1
Howland, RH	1
Polesin, A; Stern, M	1
Doi, T; Kato, T; Nikaido, K; Takayama, R	1
Ben-Ezra, J; Massey, GV; Riley, RS; Russell, EC; Williams, DC	1
Goto, S; Ishitsu, T; Murata, T; Nakada, N; Nakagawa, K; Seo, T; Ueda, N	1
Edelbroek, PM; Vermeij, TA	1
Ito, M; Okumura, A; Ozawa, H; Tsuji, T; Watanabe, K	1
Takahashi, Y	1
Lee, EL; Tor, PC	1
Abou-Khalil, B; Montouris, G	1
Coubes, P; Crespel, A; Gélisse, P; Genton, P; Velizarova, R	1
Akagi, M; Fujiwara, A; Ishikawa, T; Kaida, Y; Kamei, C; Takechi, K; Watanabe, Y	1
Arai, H; Iimura, Y; Nakajima, M; Sugano, H	1
Imai, K; Inoue, K; Inoue, Y; Itoh, K; Kagawa, Y; Mishima, N; Takahashi, Y; Yamamoto, Y; Yazawa, R	1
Greenhalgh, J; Marson, AG; Pulman, J	1
Greenhalgh, J; Marson, AG; Weston, J	1
Andermann, E; Andermann, F; de la Loge, C; Frucht, SJ; Genton, P; Gerard, D; Kälviäinen, R; Magaudda, A; Schlit, AF; von Rosenstiel, P	1
Abe, S; Azuma, Y; Ishihara, N; Ito, Y; Itomi, K; Kidokoro, H; Kojima, S; Kurahashi, H; Kurahashi, N; Maruyama, K; Natsume, J; Negoro, T; Okumura, A; Suzuki, M; Takeuchi, T; Tsuji, T; Watanabe, K; Yamada, K; Yamamoto, H	1
Bastin, ML; Cook, AM; Oyler, DR; Smetana, KS	1
Coppola, G; Operto, FF; Piccorossi, A; Verrotti, A	1
Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J	2
Dundar, Y; Greenhalgh, J; Marson, AG; Nevitt, SJ; Weston, J	2
Heo, K; Ki, CS; Kim, KH; Park, CW; Song, JS	1
Ahmed, SI; Laghari, AA; Qadeer, N; Shamim, MS	1
Croom, JE; Fields, RK; Ilieva, HS; Newman, JW	1
Beier, CP; Gesche, J; Hjalgrim, H; Rubboli, G	1
Kawakita, C; Matsuoka-Uchiyama, N; Mifune, T; Sugiyama, H; Tanabe, K; Wada, J	1
Appleton, R; Baker, G; Balabanova, S; Brown, R; Burnside, G; Hindley, D; Howell, S; Hughes, DA; Leach, JP; Maguire, M; Marson, AG; Mohanraj, R; Plumpton, CO; Sills, G; Smith, D; Smith, PE; Taylor, C; Tudur-Smith, C; Williamson, PR	1
Battino, D; Bromley, R; Kochen, S; Meador, KJ; Pennell, PB; Thomas, SV; Tomson, T	1
Schubert-Bast, S; Strzelczyk, A	1
O'Sullivan, S; Pizarro, J; Walker, MC	1
Eadie, M; Graham, J; Hitchcock, A; Lander, C; O'Brien, T; Perucca, P; Vajda, F	1
Knake, S; Kovac, S; Rosenow, F; Strzelczyk, A; van der Goten, M; von Podewils, F; Willems, LM; Zöllner, JP	1

Reviews

20 review(s) available for zonisamide and valproic acid

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Myoclonus and epilepsy in childhood: a review of treatment with valproate, ethosuximide, lamotrigine and zonisamide. Epilepsy research, 1998, Volume: 29, Issue:2 Topics: Anticonvulsants; Child; Child, Preschool; Epilepsies, Myoclonic; Ethosuximide; Humans; Infant; Isoxazoles; Lamotrigine; Triazines; Valproic Acid; Zonisamide	1998
Treating bipolar depression. The Journal of family practice, 2003, Volume: Suppl Topics: Acetates; Affect; Amines; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Carbamazepine; Cyclohexanecarboxylic Acids; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Lithium Compounds; Nipecotic Acids; Olanzapine; Oxcarbazepine; Pirenzepine; Tiagabine; Topiramate; Treatment Outcome; Triazines; Valproic Acid; Zonisamide	2003
[Clinical guidelines for treatment of epilepsy in children]. No to hattatsu = Brain and development, 2004, Volume: 36, Issue:2 Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Cosyntropin; Electroencephalography; Epilepsy; Frontal Lobe; Humans; Isoxazoles; Life Style; Magnetic Resonance Imaging; Phenytoin; Practice Guidelines as Topic; Temporal Lobe; Valproic Acid; Zonisamide	2004
Anticonvulsant drugs in primary headaches prophylaxis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2004, Volume: 25 Suppl 3 Topics: Amines; Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Fructose; Gabapentin; gamma-Aminobutyric Acid; Headache; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Oxcarbazepine; Piracetam; Topiramate; Triazines; Valproic Acid; Vigabatrin; Zonisamide	2004
Analysis of antiepileptic drugs in biological fluids by means of electrokinetic chromatography. Electrophoresis, 2005, Volume: 26, Issue:4-5 Topics: Acetazolamide; Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Chromatography, Micellar Electrokinetic Capillary; Felbamate; Humans; Hydantoins; Isoxazoles; Lamotrigine; Phenylcarbamates; Propylene Glycols; Succinimides; Triazines; Valproic Acid; Vigabatrin; Zonisamide	2005
Anticonvulsant drug therapies. Journal of psychosocial nursing and mental health services, 2005, Volume: 43, Issue:6 Topics: Amines; Anticonvulsants; Bipolar Disorder; Carbamazepine; Cyclohexanecarboxylic Acids; Depressive Disorder; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Nurse's Role; Oxcarbazepine; Patient Selection; Safety; Topiramate; Treatment Outcome; Triazines; Valproic Acid; Zonisamide	2005
[Neuromuscular disorders caused by adverse effects of antiepileptics]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2007, Aug-10, Volume: 96, Issue:8 Topics: Amines; Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Cyclohexanecarboxylic Acids; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Neuromuscular Diseases; Phenobarbital; Phenytoin; Topiramate; Valproic Acid; Zonisamide	2007
The first line of therapy in a girl with juvenile myoclonic epilepsy: should it be valproate or a new agent? Epilepsia, 2009, Volume: 50 Suppl 8 Topics: Anticonvulsants; Congenital Abnormalities; Delayed-Action Preparations; Drug Design; Epilepsy, Generalized; Female; Fructose; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Male; Myoclonic Epilepsy, Juvenile; Piracetam; Pregnancy; Risk Assessment; Topiramate; Treatment Outcome; Triazines; Valproic Acid; Weight Gain; Zonisamide	2009
Antiepileptic drugs as prophylaxis for post-craniotomy seizures. The Cochrane database of systematic reviews, 2013, Feb-28, Issue:2 Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Phenobarbital; Phenytoin; Randomized Controlled Trials as Topic; Seizures; Valproic Acid; Zonisamide	2013
Antiepileptic drugs as prophylaxis for post-craniotomy seizures. The Cochrane database of systematic reviews, 2015, Mar-04, Issue:3 Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Phenobarbital; Phenytoin; Randomized Controlled Trials as Topic; Seizures; Valproic Acid; Zonisamide	2015
Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy. Journal of critical care, 2016, Volume: 36 Topics: Acetamides; Acute Kidney Injury; Amines; Anticonvulsants; Carbamates; Critical Illness; Cyclohexanecarboxylic Acids; Dibenzazepines; Dose-Response Relationship, Drug; Ethosuximide; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lacosamide; Lamotrigine; Levetiracetam; Phenobarbital; Phenylcarbamates; Phenylenediamines; Phenytoin; Piracetam; Propylene Glycols; Renal Dialysis; Renal Replacement Therapy; Seizures; Topiramate; Triazines; Valproic Acid; Zonisamide	2016
Anticonvulsant drugs for generalized tonic-clonic epilepsy. Expert opinion on pharmacotherapy, 2017, Volume: 18, Issue:9 Topics: Acetamides; Anticonvulsants; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Female; Fructose; Humans; Isoxazoles; Lacosamide; Lamotrigine; Levetiracetam; Male; Nitriles; Piracetam; Pyridones; Randomized Controlled Trials as Topic; Topiramate; Treatment Outcome; Triazines; Valproic Acid; Zonisamide	2017
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. The Cochrane database of systematic reviews, 2017, 06-29, Volume: 6 Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Network Meta-Analysis; Oxcarbazepine; Phenobarbital; Phenytoin; Piracetam; Remission Induction; Topiramate; Triazines; Valproic Acid; Zonisamide	2017
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. The Cochrane database of systematic reviews, 2017, 12-15, Volume: 12 Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Network Meta-Analysis; Oxcarbazepine; Phenobarbital; Phenytoin; Piracetam; Remission Induction; Topiramate; Triazines; Valproic Acid; Zonisamide	2017
Antiepileptic drugs as prophylaxis for postcraniotomy seizures. The Cochrane database of systematic reviews, 2018, 05-23, Volume: 5 Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Levetiracetam; Phenobarbital; Phenytoin; Piracetam; Postoperative Complications; Randomized Controlled Trials as Topic; Seizures; Valproic Acid; Zonisamide	2018
Choice of therapeutic anti-seizure medication in patients with brain tumour. JPMA. The Journal of the Pakistan Medical Association, 2019, Volume: 69, Issue:3 Topics: Anticonvulsants; Brain Neoplasms; Drug Therapy, Combination; Epilepsy; Gabapentin; Glioma; Humans; Lamotrigine; Levetiracetam; Neoplasm Grading; Phenytoin; Survival Rate; Topiramate; Valproic Acid; Zonisamide	2019
Antiepileptic drugs as prophylaxis for postcraniotomy seizures. The Cochrane database of systematic reviews, 2020, 04-28, Volume: 4 Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Levetiracetam; Phenobarbital; Phenytoin; Piracetam; Postoperative Complications; Randomized Controlled Trials as Topic; Seizures; Valproic Acid; Zonisamide	2020
Breastfeeding while on treatment with antiseizure medications: a systematic review from the ILAE Women Task Force Epileptic disorders : international epilepsy journal with videotape, 2022, 12-01, Volume: 24, Issue:6 Topics: Breast Feeding; Cannabidiol; Carbamazepine; Child; Clobazam; Clonazepam; Epilepsy; Ethosuximide; Everolimus; Felbamate; Female; Fenfluramine; Gabapentin; Humans; Infant; Lacosamide; Lamotrigine; Levetiracetam; Oxcarbazepine; Phenobarbital; Phenytoin; Prospective Studies; Tiagabine; Topiramate; Valproic Acid; Vigabatrin; Zonisamide	2022
Psychobehavioural and Cognitive Adverse Events of Anti-Seizure Medications for the Treatment of Developmental and Epileptic Encephalopathies. CNS drugs, 2022, Volume: 36, Issue:10 Topics: Autism Spectrum Disorder; Bromides; Cannabidiol; Clobazam; Cognition; Ethosuximide; Everolimus; Felbamate; Fenfluramine; Humans; Lacosamide; Lamotrigine; Levetiracetam; Pregabalin; Spasms, Infantile; Sulfides; Topiramate; Valproic Acid; Vigabatrin; Zinc Compounds; Zonisamide	2022

Trials

6 trial(s) available for zonisamide and valproic acid

Article	Year
Developmental and therapeutic pharmacology of antiepileptic drugs. The Japanese journal of psychiatry and neurology, 1993, Volume: 47, Issue:2 Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Electroencephalography; Epilepsy; Female; Half-Life; Humans; Infant; Isoxazoles; Male; Phenytoin; Prospective Studies; Valproic Acid; Zonisamide	1993
The effects of antiepileptic drugs on cognition in normal volunteers. Psychiatry and clinical neurosciences, 1996, Volume: 50, Issue:2 Topics: Adult; Anticonvulsants; Carbamazepine; Cognition; Cross-Over Studies; Double-Blind Method; Humans; Isoxazoles; Phenytoin; Valproic Acid; Wechsler Scales; Zonisamide	1996
Developmental and therapeutic pharmacology of antiepileptic drugs. Epilepsia, 2000, Volume: 41 Suppl 9 Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Administration Schedule; Drug Industry; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy; Half-Life; Humans; Infant; Intestinal Absorption; Isoxazoles; Lamotrigine; Prospective Studies; Treatment Outcome; Triazines; Valproic Acid; Zonisamide	2000
Current treatment of West syndrome in Japan. Journal of child neurology, 2007, Volume: 22, Issue:5 Topics: Adrenocorticotropic Hormone; Anticonvulsants; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infant; Infant, Newborn; Isoxazoles; Japan; Male; Practice Patterns, Physicians'; Spasms, Infantile; Surveys and Questionnaires; Valproic Acid; Vitamin B 6; Zonisamide	2007
Brivaracetam in Unverricht-Lundborg disease (EPM1): Results from two randomized, double-blind, placebo-controlled studies. Epilepsia, 2016, Volume: 57, Issue:2 Topics: Adolescent; Adult; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Fructose; Humans; Isoxazoles; Levetiracetam; Male; Middle Aged; Phenobarbital; Piracetam; Pyrrolidinones; Topiramate; Treatment Outcome; Unverricht-Lundborg Syndrome; Valproic Acid; Young Adult; Zonisamide	2016
Lamotrigine versus levetiracetam or zonisamide for focal epilepsy and valproate versus levetiracetam for generalised and unclassified epilepsy: two SANAD II non-inferiority RCTs. Health technology assessment (Winchester, England), 2021, Volume: 25, Issue:75 Topics: Child, Preschool; Cost-Benefit Analysis; Epilepsies, Partial; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; Quality of Life; Valproic Acid; Zonisamide	2021

Other Studies

39 other study(ies) available for zonisamide and valproic acid

Article	Year
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship	2003
Inhibition of aquaporin 4 by antiepileptic drugs. Bioorganic & medicinal chemistry, 2009, Jan-01, Volume: 17, Issue:1 Topics: Animals; Anticonvulsants; Aquaporin 4; Computer Simulation; Drug Evaluation, Preclinical; Humans; Oocytes; Protein Binding; Thermodynamics; Xenopus	2009
Synthesis and anticonvulsant activity of aromatic tetramethylcyclopropanecarboxamide derivatives. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Administration, Oral; Amides; Animals; Anticonvulsants; Cyclopropanes; Electroshock; Isoxazoles; Mice; Motor Activity; Rats; Seizures; Sulfonamides; Urea; Valproic Acid; Zonisamide	2008
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate. Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24 Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility	2010
Pharmacokinetic interaction of zonisamide in rats. Effect of other antiepileptics on zonisamide. Journal of pharmacobio-dynamics, 1992, Volume: 15, Issue:11 Topics: Administration, Oral; Animals; Anticonvulsants; Blood Proteins; Diethylcarbamazine; Drug Interactions; Erythrocytes; Half-Life; Isoxazoles; Male; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Rats, Wistar; Valproic Acid; Zonisamide	1992
[Effect of anticonvulsants upon experimental limbic seizure status and regional cerebral blood flow in the hippocampus]. No to shinkei = Brain and nerve, 1992, Volume: 44, Issue:3 Topics: Animals; Anticonvulsants; Cats; Diazepam; Electroencephalography; Hippocampus; Isoxazoles; Phenobarbital; Phenytoin; Regional Blood Flow; Status Epilepticus; Valproic Acid; Zonisamide	1992
Therapeutic concentration of antiepileptic drugs and the severity of epileptogenesis. Electroencephalography and clinical neurophysiology. Supplement, 1982, Volume: 36 Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Isoxazoles; Phenytoin; Valproic Acid; Zonisamide	1982
Pharmacokinetic interaction of zonisamide in rats. Effect of zonisamide on other antiepileptics. Biological & pharmaceutical bulletin, 1993, Volume: 16, Issue:7 Topics: Animals; Anticonvulsants; Blood Proteins; Carbamazepine; Drug Interactions; Erythrocytes; In Vitro Techniques; Isoxazoles; Male; Phenobarbital; Phenytoin; Protein Binding; Rats; Rats, Wistar; Valproic Acid; Zonisamide	1993
The necessity of adjusting the dosage of zonisamide when coadministered with other anti-epileptic drugs. Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:8 Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Humans; Isoxazoles; Phenobarbital; Phenytoin; Valproic Acid; Zonisamide	1996
Mechanism for reduction of serum folate by antiepileptic drugs during prolonged therapy. Journal of the neurological sciences, 1997, Volume: 145, Issue:1 Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Demography; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Humans; Infant; Isoxazoles; Male; Phenobarbital; Time Factors; Valproic Acid; Zonisamide	1997
[A case of cortical reflex myoclonus manifesting tremor]. Rinsho shinkeigaku = Clinical neurology, 1997, Volume: 37, Issue:11 Topics: Anticonvulsants; Cerebral Cortex; Clonazepam; Evoked Potentials, Somatosensory; Female; Humans; Isoxazoles; Magnetoencephalography; Middle Aged; Myoclonus; Reflex; Tremor; Valproic Acid; Zonisamide	1997
Protective effect of zonisamide, an antiepileptic drug, against transient focal cerebral ischemia with middle cerebral artery occlusion-reperfusion in rats. Epilepsia, 1997, Volume: 38, Issue:9 Topics: Animals; Anticonvulsants; Arterial Occlusive Diseases; Body Temperature; Carbamazepine; Cerebral Arterial Diseases; Cerebral Infarction; Humans; Ischemic Attack, Transient; Isoxazoles; Male; Rats; Rats, Sprague-Dawley; Reperfusion; Valproic Acid; Zonisamide	1997
Subsidence of seizure induced by stereotactic radiation in a patient with hypothalamic hamartoma. Case report. Journal of neurosurgery, 1998, Volume: 89, Issue:4 Topics: Adult; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Follow-Up Studies; Hamartoma; Humans; Hypothalamic Diseases; Isoxazoles; Magnetic Resonance Imaging; Male; Radiosurgery; Tomography, X-Ray Computed; Valproic Acid; Zonisamide	1998
Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytryptamine uptake in rats. European journal of pharmacology, 1998, Sep-25, Volume: 358, Issue:1 Topics: Acetates; Amines; Animals; Anticonvulsants; Biogenic Amines; Blood Platelets; Brain; Carbamazepine; Cyclohexanecarboxylic Acids; Dopamine; Dopamine Uptake Inhibitors; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Lithium; Male; Norepinephrine; p-Chloroamphetamine; Phenytoin; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Agents; Serotonin Syndrome; Synaptosomes; Tetrodotoxin; Triazines; Valproic Acid; Zonisamide	1998
Effects of combined administration of zonisamide and valproic acid or phenytoin to nitric oxide production, monoamines and zonisamide concentrations in the brain of seizure-susceptible EL mice. Brain research bulletin, 2000, Sep-15, Volume: 53, Issue:2 Topics: Animals; Anticonvulsants; Biogenic Monoamines; Brain; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Epilepsy; Isoxazoles; Mice; Mice, Mutant Strains; Nitric Oxide; Phenytoin; Valproic Acid; Zonisamide	2000
Smoldering myeloma associated with zonisamide treatment. Internal medicine (Tokyo, Japan), 2002, Volume: 41, Issue:2 Topics: Adult; Agammaglobulinemia; Anticonvulsants; Epilepsy, Generalized; Humans; Immunoglobulin lambda-Chains; Intracranial Arteriovenous Malformations; Isoxazoles; Male; Multiple Myeloma; Myeloma Proteins; Subarachnoid Hemorrhage; Valproic Acid; Zonisamide	2002
[Clinical features and treatment of refractory epilepsy in children]. Rinsho shinkeigaku = Clinical neurology, 2001, Volume: 41, Issue:12 Topics: Adolescent; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Clonazepam; Epilepsy; Female; Humans; Infant; Infant, Newborn; Isoxazoles; Male; Retrospective Studies; Treatment Outcome; Valproic Acid; Zonisamide	2001
Effects of valproate, phenytoin, and zonisamide on clonic and tonic seizures induced by acute and repeated exposure of mice to flurothyl. Physiology & behavior, 2003, Volume: 78, Issue:3 Topics: Animals; Anticonvulsants; Brain Stem; Convulsants; Epilepsy, Tonic-Clonic; Flurothyl; Isoxazoles; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Phenytoin; Prosencephalon; Seizures; Time Factors; Valproic Acid; Zonisamide	2003
Influence of coadministered antiepileptic drugs on serum phenobarbital concentrations in epileptic patients: quantitative analysis based on a suitable transforming factor. Biological & pharmaceutical bulletin, 2004, Volume: 27, Issue:12 Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Combinations; Epilepsy; Female; Humans; Infant; Isoxazoles; Male; Middle Aged; Phenobarbital; Phenytoin; Sex Factors; Valproic Acid; Zonisamide	2004
Efficacy and tolerability of zonisamide in juvenile myoclonic epilepsy. Epileptic disorders : international epilepsy journal with videotape, 2004, Volume: 6, Issue:4 Topics: Adolescent; Adult; Anticonvulsants; Child; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, Absence; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Female; Humans; Isoxazoles; Male; Myoclonic Epilepsy, Juvenile; Retrospective Studies; Treatment Outcome; Valproic Acid; Zonisamide	2004
Lack of pharmacokinetic interactions between steady-state zonisamide and valproic acid in patients with epilepsy. Clinical pharmacokinetics, 2005, Volume: 44, Issue:5 Topics: Adult; Anticonvulsants; Drug Interactions; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Valproic Acid; Zonisamide	2005
Post-anoxic myoclonus: a case presentation and review of management in the rehabilitation setting. Brain injury, 2006, Volume: 20, Issue:2 Topics: Anticonvulsants; Clonazepam; Diazepam; Female; Heart Arrest; Humans; Hypoxia, Brain; Isoxazoles; Levetiracetam; Middle Aged; Myoclonus; Phenobarbital; Piracetam; Valproic Acid; Zonisamide	2006
[Valproate sodium and zonisamide associated interstitial pneumonitis in an infant]. No to hattatsu = Brain and development, 2007, Volume: 39, Issue:1 Topics: Anticonvulsants; Epilepsy; Female; Humans; Infant; Isoxazoles; Lung Diseases, Interstitial; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, Human; Spasms, Infantile; Valproic Acid; Zonisamide	2007
Translocation-positive acute myeloid leukemia associated with valproic acid therapy. Pediatric blood & cancer, 2008, Volume: 50, Issue:3 Topics: Acute Disease; Anticonvulsants; Cell Differentiation; Cell Division; Child, Preschool; Chromosomes, Human, Pair 16; Chromosomes, Human, Pair 8; Clone Cells; Cocarcinogenesis; Drug Therapy, Combination; Epilepsy, Absence; Female; Humans; Isoxazoles; Lamotrigine; Leukemia, Myeloid; Levetiracetam; Neoplastic Stem Cells; Oncogene Proteins, Fusion; Phenobarbital; Piracetam; Translocation, Genetic; Triazines; Valproic Acid; Zonisamide	2008
Population estimation of the effects of cytochrome P450 2C9 and 2C19 polymorphisms on phenobarbital clearance in Japanese. Therapeutic drug monitoring, 2007, Volume: 29, Issue:1 Topics: Adult; Algorithms; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Asian People; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Drug Monitoring; Epilepsy; Female; Gene Frequency; Genetics, Population; Heterozygote; Homozygote; Humans; Immunoassay; Isoxazoles; Japan; Male; Metabolic Clearance Rate; Mixed Function Oxygenases; Phenobarbital; Phenytoin; Polymorphism, Genetic; Regression Analysis; Valproic Acid; Zonisamide	2007
Robust isocratic high performance liquid chromatographic method for simultaneous determination of seven antiepileptic drugs including lamotrigine, oxcarbazepine and zonisamide in serum after solid-phase extraction. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Sep-15, Volume: 857, Issue:1 Topics: Analysis of Variance; Animals; Anticonvulsants; Carbamazepine; Cattle; Chromatography, High Pressure Liquid; Drug Monitoring; Ethosuximide; Humans; Isoxazoles; Lamotrigine; Oxcarbazepine; Phenobarbital; Phenytoin; Primidone; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Solutions; Specimen Handling; Spectrophotometry, Ultraviolet; Temperature; Triazines; Valproic Acid; Zonisamide	2007
Treatment emergent mania responding to valproate in a Chinese female adolescent population with eating disorders: a case series. European eating disorders review : the journal of the Eating Disorders Association, 2008, Volume: 16, Issue:6 Topics: Adolescent; Anorexia Nervosa; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Bulimia Nervosa; Feeding and Eating Disorders; Female; Humans; Isoxazoles; Male; Phenytoin; Risk Factors; Sex Characteristics; Singapore; Valproic Acid; Young Adult; Zonisamide	2008
Wicket spikes misinterpreted as focal abnormalities in idiopathic generalized epilepsy with prescription of carbamazepine leading to paradoxical aggravation. Neurophysiologie clinique = Clinical neurophysiology, 2009, Volume: 39, Issue:3 Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Clonazepam; Diagnostic Errors; Drug Therapy, Combination; Electroencephalography; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Female; Fructose; Humans; Isoxazoles; Middle Aged; Remission Induction; Sleep Stages; Temporal Lobe; Theta Rhythm; Topiramate; Valproic Acid; Zonisamide	2009
The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics. Epilepsia, 2010, Volume: 51, Issue:3 Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Epilepsy, Complex Partial; Epilepsy, Generalized; Frontal Lobe; Hippocampus; Isoxazoles; Kindling, Neurologic; Male; Olfactory Bulb; Rats; Rats, Wistar; Seizures; Valproic Acid; Zonisamide	2010
Stepwise synchronization through the corpus callosum is one cause of myoclonic jerks. World neurosurgery, 2012, Volume: 77, Issue:2 Topics: Anticonvulsants; Cognition Disorders; Corpus Callosum; Cortical Synchronization; Drug Resistance; Electroencephalography; Functional Laterality; Humans; Isoxazoles; Magnetic Resonance Imaging; Male; Myoclonus; Neurosurgical Procedures; Seizures; Syncope; Valproic Acid; Young Adult; Zonisamide	2012
Risk factors for hyperammonemia in pediatric patients with epilepsy. Epilepsia, 2013, Volume: 54, Issue:6 Topics: Acetazolamide; Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; Female; Fructose; Humans; Hyperammonemia; Infant; Isoxazoles; Male; Phenobarbital; Phenytoin; Retrospective Studies; Risk Factors; Sex Factors; Topiramate; Valproic Acid; Zonisamide	2013
The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy. Brain & development, 2016, Volume: 38, Issue:8 Topics: Adolescent; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool; Clobazam; Clonazepam; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; Infant, Newborn; Isoxazoles; Japan; Lamotrigine; Levetiracetam; Male; Phenobarbital; Phenytoin; Piracetam; Triazines; Valproic Acid; Young Adult; Zonisamide	2016
First Molecular Diagnosis of a Patient with Unverricht-Lundborg Disease in Korea. Yonsei medical journal, 2018, Volume: 59, Issue:6 Topics: Adult; Anticonvulsants; Blotting, Southern; Cystatin B; Female; Genetic Predisposition to Disease; Humans; Isoxazoles; Levetiracetam; Piracetam; Republic of Korea; Seizures; Treatment Outcome; Unverricht-Lundborg Syndrome; Valproic Acid; Zonisamide	2018
Valproic acid and zonisamide induced hyperammonemic encephalopathy. Clinical neurology and neurosurgery, 2020, Volume: 196 Topics: Adult; Anticonvulsants; Brain; Brain Diseases; Epilepsy; Humans; Hyperammonemia; Magnetic Resonance Imaging; Male; Valproic Acid; Zonisamide	2020
Risk factors of paradoxical reactions to anti-seizure medication in genetic generalized epilepsy. Epilepsy research, 2021, Volume: 170 Topics: Adult; Anticonvulsants; Epilepsy, Generalized; Humans; Lamotrigine; Levetiracetam; Myoclonic Epilepsy, Juvenile; Phenobarbital; Retrospective Studies; Risk Factors; Seizures; Valproic Acid; Zonisamide	2021
Management of corticosteroid-dependent eosinophilic interstitial nephritis: A case report. Medicine, 2021, Dec-17, Volume: 100, Issue:50 Topics: Adrenal Cortex Hormones; Adult; Biopsy; Creatinine; Humans; Lacosamide; Male; Mycophenolic Acid; Nephritis, Interstitial; Polypharmacy; Prednisolone; Treatment Outcome; Valproic Acid; Zonisamide	2021
How accurately do adult patients report their absence seizures? Epilepsia open, 2023, Volume: 8, Issue:2 Topics: Adult; Epilepsy, Absence; Female; Humans; Inpatients; Male; Seizures; Valproic Acid; Zonisamide	2023
Specific fetal malformations following intrauterine exposure to antiseizure medication. Epilepsy & behavior : E&B, 2023, Volume: 142 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Carbamazepine; Female; Humans; Male; Pregnancy; Pregnancy Complications; Topiramate; Valproic Acid; Zonisamide	2023
Adverse Event Profiles of Antiseizure Medications and the Impact of Coadministration on Drug Tolerability in Adults with Epilepsy. CNS drugs, 2023, Volume: 37, Issue:6 Topics: Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anticonvulsants; Epilepsy; Humans; Levetiracetam; Retrospective Studies; Topiramate; Valproic Acid; Zonisamide	2023