Page last updated: 2024-08-16

zomepirac and zomepirac glucuronide

zomepirac has been researched along with zomepirac glucuronide in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19902 (33.33)18.7374
1990's3 (50.00)18.2507
2000's0 (0.00)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Benet, LZ; McDonagh, AF; Smith, PC1
Benet, LZ; Hasegawa, J; Langendijk, PN; Smith, PC1
Calatroni, A; Pietta, P1
Bailey, MJ; de Jersey, J; Dickinson, RG; Worrall, S1
Bailey, MJ; Dickinson, RG1
Akai, S; Iwamura, A; Kume, T; Nishinosono, T; Oda, S; Tsuneyama, K; Watanabe, K; Yokoi, T1

Other Studies

6 other study(ies) available for zomepirac and zomepirac glucuronide

ArticleYear
Effect of esterase inhibition on the disposition of zomepirac glucuronide and its covalent binding to plasma proteins in the guinea pig.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:1

    Topics: Anesthesia; Animals; Blood Proteins; Clofibric Acid; Esterases; Guinea Pigs; Hydrolysis; Male; Metabolic Clearance Rate; Phenylmethylsulfonyl Fluoride; Protein Binding; Rabbits; Sulfones; Tolmetin

1990
Simultaneous determination of zomepirac and its major metabolite zomepirac glucuronide in human plasma and urine.
    Journal of chromatography, 1984, May-11, Volume: 307, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Pyrroles; Spectrophotometry, Ultraviolet; Tolmetin

1984
High-performance liquid chromatographic assay for zomepirac and its main metabolite in urine.
    Journal of chromatography, 1983, Jun-10, Volume: 275, Issue:1

    Topics: Chromatography, High Pressure Liquid; Humans; Microchemistry; Pyrroles; Tolmetin

1983
Zomepirac acyl glucuronide covalently modifies tubulin in vitro and in vivo and inhibits its assembly in an in vitro system.
    Chemico-biological interactions, 1998, Sep-04, Volume: 115, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Liver; Microtubules; Rats; Stereoisomerism; Structure-Activity Relationship; Tolmetin; Tubulin

1998
Limitations of hepatocytes and liver homogenates in modelling in vivo formation of acyl glucuronide-derived drug-protein adducts.
    Journal of pharmacological and toxicological methods, 1999, Volume: 41, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Blotting, Western; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Glucuronates; Glycosylation; Liver; Male; Protein Binding; Rats; Rats, Wistar; Tolmetin

1999
Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice.
    Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:7

    Topics: Acute Kidney Injury; Animals; Antioxidants; Biomarkers; Biotransformation; Blood Urea Nitrogen; Buthionine Sulfoximine; Creatinine; Cyclic N-Oxides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Inflammation Mediators; Kidney; Mice, Inbred BALB C; Oxidative Stress; Spin Labels; Time Factors; Tolmetin; Tritolyl Phosphates

2016