zoledronic acid has been researched along with geranylgeraniol in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 12 (63.16) | 24.3611 |
| 2020's | 2 (10.53) | 2.80 |
| Authors | Studies |
|---|---|
| Berghuis, AM; Gómez Palou, M; Huang, XF; Lacbay, CM; Park, J; Sebag, M; Ta, V; Tsantrizos, YS; Vincent, F; Waller, DD | 1 |
| Hiraga, T; Tamura, D; Ueda, A; Williams, PJ; Yoneda, T | 1 |
| Coleman, RE; Evans, CA; Holen, I; Neville-Webbe, HL; Rostami-Hodjegan, A | 1 |
| Bieler, G; Hasmim, M; Rüegg, C | 1 |
| Cho, R; Koizumi, M; Nakaseko, C; Nishimura, M; Ohwada, C; Ozawa, S; Saito, Y; Shimizu, N; Takeuchi, M | 1 |
| Mitrofan, LM; Mönkkönen, J; Pelkonen, J | 1 |
| Chang, HJ; Chang, JW; Li, YY; Liu, YC; Su, SP; Tsai, MC; Wang, CH; Yeh, KY | 1 |
| Ikebe, T; Kajiya, H; Kimachi, K; Nakayama, S; Okabe, K | 1 |
| Cozin, M; Cremers, S; Dadaian, SC; Landesberg, R; Pinker, BM; Raghavan, S; Solemani, K; Zuniga, JM | 1 |
| Coates, DE; Cullinan, MP; Drummond, BK; Milne, T; Seymour, GJ; Zafar, S | 2 |
| Hagelauer, N; Pabst, AM; Walter, C; Ziebart, T | 1 |
| Hiroshima, K; Jiang, Y; Kawamura, K; Kobayashi, H; Okamoto, S; Sekine, I; Shimada, H; Shingyoji, M; Tada, Y; Tagawa, M; Takiguchi, Y; Tatsumi, K | 1 |
| Jacobs, C; Krüger, M; Pabst, AM; Sagheb, K; Walter, C; Ziebart, T | 1 |
| Cheng, HL; Hsieh, MJ; Lin, CW; Lu, KH; Yang, JS; Yang, SF | 1 |
| Abdullah, MI; Abed, MN; Richardson, A | 1 |
| Gjorgoski, I; Koneski, F; Krajoska, J; Muratovska, I; Petrushevska, G; Popovic-Monevska, D; Popovska, M; Popovski, V; Velickovski, B | 1 |
| E Coates, D; J Seymour, G; K Drummond, B; P Cullinan, M; Zafar, S | 1 |
| Coates, DE; Milne, TJ; Zafar, S | 1 |
19 other study(ies) available for zoledronic acid and geranylgeraniol
| Article | Year |
|---|---|
Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors.
Topics: Apoptosis; Catalytic Domain; Cell Proliferation; Enzyme Inhibitors; Geranylgeranyl-Diphosphate Geranylgeranyltransferase; Humans; Inhibitory Concentration 50; Models, Molecular; Multiple Myeloma; Protein Prenylation; Pyrimidines; rap1 GTP-Binding Proteins | 2018 |
Zoledronic acid inhibits visceral metastases in the 4T1/luc mouse breast cancer model.
Topics: Animals; Apoptosis; Blotting, Western; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Separation; Cell Survival; Diphosphonates; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Female; Flow Cytometry; Humans; Imidazoles; Luciferases; Lung Neoplasms; Mammary Neoplasms, Animal; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Neoplasm Invasiveness; Neoplasm Metastasis; Osteoclasts; Time Factors; Zoledronic Acid | 2004 |
Sequence- and schedule-dependent enhancement of zoledronic acid induced apoptosis by doxorubicin in breast and prostate cancer cells.
Topics: Antibiotics, Antineoplastic; Apoptosis; Breast Neoplasms; Diphosphonates; Diterpenes; Doxorubicin; Drug Synergism; Drug Therapy, Combination; Female; Humans; Imidazoles; Male; Mevalonic Acid; Prostatic Neoplasms; Time Factors; Tumor Cells, Cultured; Zoledronic Acid | 2005 |
Zoledronate inhibits endothelial cell adhesion, migration and survival through the suppression of multiple, prenylation-dependent signaling pathways.
Topics: Angiogenesis Inhibitors; Bone Density Conservation Agents; Cell Adhesion; Cell Movement; Cell Survival; Cells, Cultured; Diphosphonates; Diterpenes; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Farnesol; Focal Adhesion Kinase 1; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; Phosphorylation; Protein Kinase Inhibitors; Protein Prenylation; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins c-akt; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Tumor Necrosis Factor-alpha; Umbilical Veins; Zoledronic Acid | 2007 |
Zoledronate has an antitumor effect and induces actin rearrangement in dexamethasone-resistant myeloma cells.
Topics: Actins; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Survival; Dexamethasone; Diphosphonates; Diterpenes; Drug Resistance, Neoplasm; Humans; Imidazoles; Multiple Myeloma; Protein Prenylation; rap1 GTP-Binding Proteins; rhoA GTP-Binding Protein; Zoledronic Acid | 2007 |
The level of ATP analog and isopentenyl pyrophosphate correlates with zoledronic acid-induced apoptosis in cancer cells in vitro.
Topics: Adenosine Triphosphate; Apoptosis; Cell Line, Tumor; Diphosphonates; Diterpenes; Drug Resistance, Neoplasm; Hemiterpenes; Humans; Imidazoles; Lovastatin; Membrane Potential, Mitochondrial; Neoplasms; Organophosphorus Compounds; Zoledronic Acid | 2009 |
Zoledronic acid induces cell-cycle prolongation in murine lung cancer cells by perturbing cyclin and Ras expression.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Diphosphonates; Diterpenes; Down-Regulation; E2F Transcription Factors; Imidazoles; Lung Neoplasms; Mevalonic Acid; Mice; Mice, Inbred BALB C; Phosphorylation; Protein Transport; ras Proteins; Retinoblastoma Protein; Zoledronic Acid | 2011 |
Zoledronic acid inhibits RANK expression and migration of osteoclast precursors during osteoclastogenesis.
Topics: Acid Phosphatase; Animals; Bone Marrow Cells; Bone Resorption; Cell Differentiation; Cell Line, Tumor; Cell Movement; Diphosphonates; Diterpenes; Dose-Response Relationship, Drug; Gene Expression; I-kappa B Proteins; Imidazoles; Isoenzymes; Macrophages; Mice; Mice, Inbred Strains; NF-kappa B; NF-KappaB Inhibitor alpha; Osteoclasts; Phosphorylation; Protein Prenylation; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Signal Transduction; Stem Cells; Tartrate-Resistant Acid Phosphatase; Transcription, Genetic; Tumor Necrosis Factor-alpha; Up-Regulation; Zoledronic Acid | 2011 |
Novel therapy to reverse the cellular effects of bisphosphonates on primary human oral fibroblasts.
Topics: Actins; Apoptosis; Becaplermin; Bone Density Conservation Agents; Caspase 3; Cell Adhesion; Cell Culture Techniques; Cell Movement; Cell Proliferation; Diphosphonates; Diterpenes; Fibroblasts; Gingiva; Humans; Imidazoles; In Situ Nick-End Labeling; Pamidronate; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Recombinant Proteins; Wound Healing; Zoledronic Acid | 2011 |
Zoledronic acid and geranylgeraniol regulate cellular behaviour and angiogenic gene expression in human gingival fibroblasts.
Topics: Adult; Apoptosis; Bone Density Conservation Agents; Bone Morphogenetic Protein 2; Cell Culture Techniques; Cell Survival; Cells, Cultured; Diphosphonates; Diterpenes; Epiregulin; Farnesol; Female; Fibroblasts; Gene Expression Regulation; Gingiva; Humans; Imidazoles; Interferon-alpha; Mevalonic Acid; Microscopy, Electron, Transmission; Middle Aged; Neovascularization, Physiologic; Polyisoprenyl Phosphates; rhoB GTP-Binding Protein; Sesquiterpenes; Signal Transduction; Vascular Endothelial Growth Factor A; Zoledronic Acid | 2014 |
Bisphosphonates inhibit cell functions of HUVECs, fibroblasts and osteogenic cells via inhibition of protein geranylgeranylation.
Topics: Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Cell Movement; Cell Survival; Cells, Cultured; Cyclohexenes; Diphosphonates; Diterpenes; Endothelial Cells; Eugenol; Farnesol; Fibroblasts; Humans; Imidazoles; Limonene; Menthol; Osteogenesis; Protein Prenylation; Recurrence; Squalene; Terpenes; Umbilical Veins; Zoledronic Acid | 2015 |
Zoledronic acid induces apoptosis and S-phase arrest in mesothelioma through inhibiting Rab family proteins and topoisomerase II actions.
Topics: Apoptosis; cdc42 GTP-Binding Protein; Cell Line, Tumor; Diphosphonates; Diterpenes; DNA Topoisomerases, Type II; Farnesol; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Leucine; Mesothelioma; Myeloid Cell Leukemia Sequence 1 Protein; Protein Prenylation; rab GTP-Binding Proteins; rac1 GTP-Binding Protein; rhoA GTP-Binding Protein; RNA, Small Interfering; S Phase; Signal Transduction; Transferases; Zoledronic Acid | 2014 |
The influence of geranylgeraniol on human oral keratinocytes after bisphosphonate treatment: An in vitro study.
Topics: Apoptosis; Bone Density Conservation Agents; Cell Culture Techniques; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Clodronic Acid; Diphosphonates; Diterpenes; Humans; Ibandronic Acid; Imidazoles; Keratinocytes; Mouth Mucosa; Pamidronate; Zoledronic Acid | 2015 |
Effects of zoledronic acid and geranylgeraniol on the cellular behaviour and gene expression of primary human alveolar osteoblasts.
Topics: Adolescent; Adult; Alveolar Process; Apoptosis; Biomarkers; Bone Density Conservation Agents; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Diphosphonates; Diterpenes; Female; Gene Expression; Humans; Imidazoles; Microscopy, Electron, Transmission; Middle Aged; Osteoblasts; Real-Time Polymerase Chain Reaction; Zoledronic Acid | 2016 |
Zoledronate blocks geranylgeranylation not farnesylation to suppress human osteosarcoma U2OS cells metastasis by EMT via Rho A activation and FAK-inhibited JNK and p38 pathways.
Topics: Biological Transport; Bone Density Conservation Agents; Bone Neoplasms; Cadherins; cdc42 GTP-Binding Protein; Cell Line, Tumor; Cell Movement; Cell Survival; Diphosphonates; Diterpenes; Epithelial-Mesenchymal Transition; Farnesol; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Neoplasm Invasiveness; Nuclear Proteins; Osteoporosis; Osteosarcoma; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prenylation; Proto-Oncogene Proteins pp60(c-src); rho-Associated Kinases; Snail Family Transcription Factors; Twist-Related Protein 1; Zoledronic Acid | 2016 |
Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Diterpenes; Female; Geranyltranstransferase; GTP Phosphohydrolases; Humans; Imidazoles; Leucine; Mevalonic Acid; Naphthalenes; Ovarian Neoplasms; Quinolines; Zoledronic Acid | 2017 |
In vivo effects of geranylgeraniol on the development of bisphosphonate-related osteonecrosis of the jaws.
Topics: Animals; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Diphosphonates; Diterpenes; Imidazoles; Male; Rats; Rats, Wistar; Zoledronic Acid | 2018 |
Effects of zoledronic acid and geranylgeraniol on angiogenic gene expression in primary human osteoclasts.
Topics: Bone Density Conservation Agents; Diterpenes; Humans; Imidazoles; Leukocytes, Mononuclear; Osteoclasts; Zoledronic Acid | 2020 |
Quantitative Real-Time Gene Profiling of Human Alveolar Osteoblasts Using a One-Step System.
Topics: Diphosphonates; Humans; Osteoblasts; Polymerase Chain Reaction; Zoledronic Acid | 2023 |